Evidence-based management of adult traumatic brain injury with raised intracranial pressure in intensive critical care unit at resource-limited settings: a literature review

Abstract

Background: In underdeveloped countries, there is a greater incidence of mortality and morbidity arising from trauma, with traumatic brain injury accounting for 50% of all trauma-related deaths. The occurrence of elevated intracranial pressure, which is a common pathophysiological phenomenon in cases of traumatic brain injury, acts as a contributing factor to unfavorable outcomes. The aim of this systematic review is to analyze the existing literature regarding the management of adult traumatic brain injury with raised intracranial pressure in an intensive critical care unit, despite limited resources. Methods: This systematic review was performed in accordance with the Preferred Reporting Items for Systematic Review and Meta-Analysis protocol. Search engines such as PubMed, Cochrane database, and Google Scholar were utilized to locate high-level evidence that would facilitate the formation of sound conclusions. Result: A total of 11,715 articles were identified and individually assessed to determine their eligibility for inclusion or exclusion based on predetermined criteria and outcome variables. The methodological quality of each study was evaluated using recommended criteria. Ultimately, the review consisted of 51 articles. Conclusion: Physical examination results and noninvasive assessments of the Optic Nerve Sheath Diameter (ONSD) via sonography are positively associated with elevated intracranial pressure, and are employed as diagnostic and monitoring tools for elevated intracranial pressure in resource-limited settings. Management of elevated intracranial pressure necessitates an algorithmic approach that utilizes prophylactic measures and acute intervention treatments to mitigate the risk of secondary brain injury.