Evidence-based guideline recommendations on multiparametric magnetic resonance imaging in the diagnosis of prostate cancer: A Cancer Care Ontario clinical practice guideline

Abstract

Cite as: Can Urol Assoc J 2017;11(1-2):E1-7. http://dx.doi.org/10.5489/cuaj.3968 Published online January 12, 2017 AbstractThis clinical guideline focuses on: 1) the use of multiparametric magnetic resonance imaging (mpMRI) in diagnosing clinically significant prostate cancer (CSPC) in patients with an elevated risk of CSPC and who are biopsy-naïve; and 2) the use of mpMRI in diagnosing CSPC in patients with a persistently elevated risk of having CSPC and who have a negative transrectal ultrasound (TRUS)-guided systematic biopsy.

Transrectal ultrasound-guided biopsy for prostate cancer detection: Systematic and/or magnetic-resonance imaging-targeted

“…7 The National Institute for Health and Care Excellent (NICE) and Cancer Care Ontario (CCO) clinical practice guideline recommend the use of mpMRI before a repeat biopsy. 33,34 Our results corroborate these recommendations and are in favour of the use of targeted only biopsies in order to reduce the number of cores needed and potentially reduce biopsyrelated side effects.…”

Multiparametric magnetic resonance imaging-transrectal ultrasoundguided cognitive fusion biopsy of the prostate: Clinically significant cancer detection rates stratified by the Prostate Imaging and Data Reporting System version 2 assessment categories

“…mp-MRI is particularly valuable for detection of tumors located anterior to the urethra (in the anterior horns of the peripheral zone [PZ] and in the transition zone [TZ]); areas which are undersampled or not sampled at all during template transrectal ultrasound (TRUS) guided biopsy 3 . mp-MRI is increasingly being used during active surveillance (AS) for men with low volume low grade (Gleason score 3+3=6) PCa with discordant clinical findings 4,5 and in men with previously negative template biopsies and high clinical suspicion of PCa 6 . mp-MRI is also of value in biopsy naïve men, although the data in this patient population, particularly in Canada, remains immature 6 .…”

“…mp-MRI is increasingly being used during active surveillance (AS) for men with low volume low grade (Gleason score 3+3=6) PCa with discordant clinical findings 4,5 and in men with previously negative template biopsies and high clinical suspicion of PCa 6 . mp-MRI is also of value in biopsy naïve men, although the data in this patient population, particularly in Canada, remains immature 6 .…”

Rational design of ZnO@ZIF-8 nanoarrays for improved electrochemical detection of H2O2

“…11 For ZnO@ZIF-8, the peak for Zn 2p 3/2 is deconvoluted into two peaks, which belong to Zn–N (1021.46 eV) and Zn–O (1022.89 eV) respectively. 31 In Fig. 4(c), the O 1s spectrum of ZnO can be fitted into three peaks at 532.24 eV, 530.89 eV and 529.69 eV, which are attributed to hydroxyl oxygen, adsorbed oxygen and lattice oxygen.…”