Evidence-Based Guideline: Management of an Unprovoked First Seizure in Adults: Report of the Guideline Development Subcommittee of the American Academy of Neurology and the American Epilepsy Society

Abstract

Sam Wiebe: acquisition of data, analysis or interpretation of data, critical revision of the manuscript for important intellectual content. Gary Gronseth: study concept and design, acquisition of data, analysis or interpretation of data, drafting/revising the manuscript, critical revision of the manuscript for important intellectual content. David Gloss: study concept and design, acquisition of data, analysis or interpretation of data, drafting/revising the manuscript, critical revision of the manuscript for important intellectual content.

Risk of epilepsy after a single seizure in multiple sclerosis

“…Reassuringly, a recent investigation of sudden unexpected death in epilepsy based on the ICD-9 in the NPR demonstrated >90% accuracy of the epilepsy diagnosis in deceased patients, and positive predictive values of 81% and 89% have been reported from the corresponding Danish register for seizure disorders and epilepsy, respectively [11,12]. Also, the level of subsequent epilepsy detected in controls corresponded very well to the recent high-quality meta-analysis of seizure relapse risk in the American Academy of Neurology guidelines for management of a first seizure [3]. The level of epilepsy detected in patients with MS was similar to that previously reported [7].…”

Stevens‐Johnson syndrome and toxic epidermal necrolysis with antiepileptic drugs: An analysis of the US Food and Drug Administration Adverse Event Reporting System

“…One possible reason for this is the declining utilization of phenobarbital, which has become a nonpreferred therapy option in treatment guidelines due to (1) its less favorable side effect profile, (2) inclusion in the Beers Criteria for Potentially Inappropriate Medication Use in Older Adults, (3) unfavorable pharmacokinetic properties, and (4) multiple drug-drug interactions. [36][37][38] In 2 studies that utilized data from adverse-event reporting systems, AEDs were among the top medications associated with SJS/TEN. 39,40 Lamotrigine and carbamazepine were among the top 5 most common medications listed in reports for SJS/TEN in the Japanese Adverse Drug Event Report database over a 12-year period from April 2004 through April 2015.…”

Recommendations for the use of structural magnetic resonance imaging in the care of patients with epilepsy: A consensus report from the International League Against Epilepsy Neuroimaging Task Force

“…Second, they derive from clinical protocols conducted at the institutions of the members of the Neuroimaging Task Force with basic sequences available on most MR scanners and thus generalizable to many centers, regardless of the clinical setting and country. Third, they consider review papers, evidence-based guidelines, and reports on the role of structural MRI in the diagnosis and management of seizure disorders, [14][15][16][17][18][19][20][21][22][23][24][25] with particular attention to studies that meet at least some standards for evidence classification. These sources of information were complemented by a literature review based on an Ovid MEDLINE query between 2002 and 2018.…”

“…Compared to patients in whom the cause is unknown, the rate of seizure recurrence increases twofold in those with a lesion on MRI, from 10% to 26% at 1 year and from 29% to 48% at 5 years. 23 Numerous studies have related the presence and types of MRI abnormalities to clinical outcomes. In a cohort of 764 patients undergoing MRI at the time or soon after a first seizure, 23% had a potentially epileptogenic lesion, including stroke, trauma, a developmental abnormality, or a tumor.…”