Introduction. An urgent issue of modern medicine is still early diagnosis and treatment of virus-associated respiratory infections. In this context, infectious lesions of the tracheobronchial tree, associated with a high incidence and limited use of drug therapy, are of particular relevance. Analysis of individual mechanisms for the development of acute bronchitis will allow you to choose the addition of course treatment with herbal remedies with high efficiency and safety.Aim. Based on the clinical and epidemiological analysis of the incidence of acute bronchitis and the study of the pathogenetic mechanisms of the development of the disease, to determine the effectiveness of the use of herbal preparations in the course of preventive treatment.Materials and methods. An open, controlled, comparative clinical study was conducted on 63 patients with a diagnosis of acute bronchitis of viral etiology of preventive use in the complex therapy of a phytopreparation containing an extract of common ivy leaves and to evaluate its clinical efficacy and safety.Results. Analysis of the literature showed a high incidence of acute bronchitis during the outbreak of acute respiratory viral infections, the variability of the clinical course and the need to use additional methods of treatment. An early positive trend was noted in people who, in addition to standard therapy, used a phytopreparation containing an extract of ordinary ivy leaves in comparison with preparations of the amino acid derivative of cysteine relief of all symptoms already on the 5th day. The drug was easily tolerated by patients; no side effects were observed.Conclusions. Preventive use in the complex therapy of acute bronchitis, herbal preparations with mucolytic action, which facilitate sputum discharge, allows for a faster recovery.