Evidence-based comparative severity assessment in young and adult mice
Maria Reiber,
Lara von Schumann,
Verena Buchecker
et al.
Abstract:In animal-based research, welfare assessments are essential for ethical and legal reasons. However, accurate assessment of suffering in laboratory animals is often complicated by the multidimensional character of distress and pain and the associated affective states. The present study aimed to design and validate multidimensional composite measure schemes comprising behavioral and biochemical parameters based on a bioinformatics approach. Published data sets from induced and genetic mouse models of neurologica… Show more
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