Evidence-based aspects of stimulating uncomplicated wound healing with local use of acexamic acid silver salt

Pakhomov, D.V.; Блинова, Е. В.; Shimanovsky, D.N.; Kilmyashkina, M.F.; Kazaeva, M.A.; Блинов, Д. С.; Nelipa, M. V.; Nikolaev, A.V.; Alkhatatnekh, B.A.; Skachilova, S.Ya.; Bogoyavlenskaya, T.A.; Kytko, O.V.

doi:10.17116/operhirurg2020401119

Cited by 2 publications

(2 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…VEGF expression was lower than in the control group, where it was secreted in small amounts by cells in the intact mucosa, such as macrophages and fibroblasts [17]. A decrease in VEGF activity probably led to increased apoptosis of pericytes and endothelial cells, which resulted in the involution of vessels in the area of the wound defect and the formation of poorly vascularized scar tissue [18].…”

Section: G Hmentioning

confidence: 96%

Restoration of the microvasculature and hemodynamics in the oral mucosa wound defects area with and without a piezoelectric polymer membrane

Коняева¹,

Varakuta²,

Leiman³

et al. 2022

Clin. Exp. Morphology

View full text Add to dashboard Cite

Introduction. Restoration of blood supply to tissues is crucial for the regeneration of wound defects. The purpose of this research was to study the effect of piezoelectric polymers on the restoration of microcirculation and hemodynamics in the area of oral mucosa wound defects. Materials and methods. The study was carried out on 60 Wistar rats divided into four groups (15 rats each): control (intact) and 3 experimental groups. In group 1, the animals had an open wound defect. In groups 3 and 2, the rats had a wound defect covered with a membrane with and without copper modification, respectively. The specimens for subsequent light and electron microscopy were collected on days 3, 7, and 12. We studied qualitative and quantitative indicators of microcirculation and hemodynamics restoration. Results. Day 3: in all experimental groups, the arteriolo-venular relationship and the pericapillary diffusion index significantly decreased, while the Kernogan index increased. We also observed a significant increase in VEGF expression. Day 7: in experimental group 3, the values of the Kernogan index and the arteriolo-venular relationship were restored, and the pericapillary diffusion index remained significantly higher than in the control group. In the groups 1 and 2, none of the indicators reached the control values. VEGF expression decreased in all groups. On day 12 in group 1, the arteriolo-venular relationship, the Kernogan index and the index of pericapillary diffusion differed from the control group, in contrast to groups 2 and 3, where all the studied parameters were restored. Expression of VEGF in group 1 was significantly less than the control values, and in groups 2 and 3 it was significantly higher. Conclusion. We revealed that closing of oral mucosa wound defects by a piezoelectric polymer membrane led to the restoration of hemodynamic parameters and promoted active vascular formation. Keywords: wound defect, oral cavity, inflammation, regeneration, microcirculation, neoangiogenesis

show abstract

Section: G Hmentioning

confidence: 96%

Restoration of the microvasculature and hemodynamics in the oral mucosa wound defects area with and without a piezoelectric polymer membrane

Коняева¹,

Varakuta²,

Leiman³

et al. 2022

Clin. Exp. Morphology

View full text Add to dashboard Cite

show abstract

“…Organic acid LHT 21-18 is a derivative of aminocaproic acid is able to accelerate the cleansing of the wound surface from necrotic masses, reduce exudative processes, activate the growth of granulation tissue, vascularization, stimulate the formation of bone marrow, accelerating the healing process, and bone fractures (Pakhomov et al 2020).…”

Section: Introductionmentioning

confidence: 99%

Method for obtaining supramolecular complex based on 3-ohypyridine derivatives and its application for correction of osteoporosis

Trunov

2023

RRP

View full text Add to dashboard Cite

Introduction: Currently, there are no safe and ideal medicines for the prevention and treatment of oophorectomy-induced osteoporosis. The development of an effective pharmacotherapy for hypoestrogen-induced osteoporosis is an important task of pharmacology. Materials and Methods: A new supramolecular complex (composition №1) was obtained on the basis of 3-hydroxypyridine derivatives: 2-ethyl-6-methyl-3-hydroxypyridinium 3-pyridinocarbonoate and 2-ethyl-6-methyl-3-hydroxypyridinium N-acetyl-6-aminohexanoate in a ratio of 1:3 by topochemical synthesis. The study of the osteoprotective activity of the supramolecular complex at a dose of 50 mg/kg was performed on 60 white female rats of the Wistar line on a model of hypoestrogen-induced osteoporosis. The effectiveness of the osteoprotective activity of the complex was evaluated on the 57th day of the experiment. Results and Discussion: The new supramolecular complex (composition №1) has osteoprotective activity, which is expressed in improving the indicators of X-ray and histomorphological samples. Oral administration of composition №1 at a dose of 50 mg/kg led to an increase in bone density to values of 2.55±0.02 g/cm3, which is 1.3 times higher than in the control group 1.92±0.01 g/cm3 (p≤0.05) and reduce bone resorption by improving cortical and trabecular bone structures. Conclusion: The obtained data characterize the prospects of studying composition №1 for the correction and prevention of hypoestrogen-induced osteoporosis. Graphical Abstract

show abstract

Evidence-based aspects of stimulating uncomplicated wound healing with local use of acexamic acid silver salt

Cited by 2 publications

References 9 publications

Restoration of the microvasculature and hemodynamics in the oral mucosa wound defects area with and without a piezoelectric polymer membrane

Restoration of the microvasculature and hemodynamics in the oral mucosa wound defects area with and without a piezoelectric polymer membrane

Method for obtaining supramolecular complex based on 3-ohypyridine derivatives and its application for correction of osteoporosis

Contact Info

Product

Resources

About