Evidence and policy for influenza control

Antiviral treatment for outpatient use during an influenza pandemic: a decision tree model of outcomes averted and cost-effectiveness

“…[5][6][7][8][9][10][11][12][13][14] However, these trials were under-powered to assess NAI impact on secondary outcomes such as hospitalizations. [15][16][17] Two meta-analyses of the extant clinical trial data, examining outcomes based on the intention-to-treat-influenza infected (ITTI) approach, found that early NAI treatment (≤48 h of symptom onset) was associated with a risk reduction of 59 18 and 63% 19 for hospital admission in otherwise healthy patients with influenza. Other meta-analyses of trial data that evaluated all outpatients with influenza-like-illness (ILI) using the intention-to-treat (ITT) approach did not find a reduction in hospitalizations in those treated with NAIs.…”