Evidence Against the Role of Intracellular Calcium Dynamics in Ventricular Fibrillation

Warren, Mark; Av, Zaĭtsev

doi:10.1161/circresaha.108.175901

Cited by 4 publications

(3 citation statements)

References 6 publications

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“…Studies from the Zaitsev lab suggested that [Ca 2+ ] i -action potential dissociation during VF was a consequence, not a cause of wavebreaks in VF, and that no spontaneous voltage-independent [Ca 2+ ] i waves could be seen. 114,115 However, others have challenged these findings. 116 In contrast, [Ca 2+ ] i has been shown to be important in the initiation of spontaneous activity in TdP, 117 and inherited arrhythmias such as catecholaminergic polymorphic ventricular tachycardia (CPVT), which can then give rise to the initiation of rotors and fibrillation.…”

Section: Ionic Bases Of Rotorsmentioning

confidence: 99%

Rotors and the Dynamics of Cardiac Fibrillation

Pandit

Jalife

2013

Circulation Research

351

310

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The objective of this article is to present a broad review on the role of cardiac electrical rotors and their accompanying spiral waves in the mechanism of cardiac fibrillation. At the outset, we present a brief historical overview regarding reentry, and then discuss the basic concepts and terminologies pertaining to rotors and their initiation. Thereafter, the intrinsic properties of rotors and spiral waves, including phase singularities, wavefront curvature and dominant frequency maps are discussed. The implications of rotor dynamics for the spatio-temporal organization of fibrillation, independent of the species being studied are touched upon next. The knowledge gained regarding the role of cardiac structure in the initiation and/or maintenance of rotors and the ionic bases of spiral waves in the last two decades, and its significance for drug therapy is reviewed subsequently. We conclude by looking at recent evidence suggesting that rotors are critical in sustaining both atrial and ventricular fibrillation (AF, VF) in the human heart, and its implications for treatment with radio-frequency ablation.

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Section: Ionic Bases Of Rotorsmentioning

confidence: 99%

Rotors and the Dynamics of Cardiac Fibrillation

Pandit

Jalife

2013

Circulation Research

351

310

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“…MI was relatively high during pacing and VT but fell dramatically during VF, suggesting that spontaneous SR Ca i release may sustain VF by promoting wavebreak formation 77 . Although the latter findings were not reproduced in non-ischemic hearts in VF 108,109 , there is less controversy regarding the role of Ca i overload in ischemia and hypoxia 89 .…”

Section: Introductionmentioning

confidence: 99%

Deciphering Arrhythmia Mechanisms: Tools of the Trade

Salama

Akar

2011

Cardiac Electrophysiology Clinics

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Pathophysiological remodeling of cardiac function occurs at multiple levels, spanning the spectrum from molecular and sub-cellular changes to those occurring at the organ-system levels. Of key importance to arrhythmias are changes in electrophysiological and calcium handling properties at the tissue level. In this review, we discuss how high-resolution optical action potential and calcium transient imaging has advanced our understanding of basic arrhythmia mechanisms associated with multiple cardiovascular disorders, including the long QT syndrome, heart failure, and ischemia-reperfusion injury. We focus on the role of repolarization gradients (section 1) and calcium mediated triggers (section 2) in the initiation and maintenance of complex arrhythmias in these settings.

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“…A better drug regime would have included thapsigargin along with ryanodine to completely disable the calcium cycling, which has been shown to suppress focal discharges in AF models 23. The calcium chelator BAPTA would have also been an uncontroversial eliminator of calcium-induced arrhythmogenesis 24. Additionally, it is unclear whether conclusions drawn from a very specific form of AF (stretch-related) apply to others.…”

mentioning

confidence: 99%

Atrial fibrillation: The mother rotor and its rebellious offspring take turns sustaining the family

Valderrábano¹

2009

Heart Rhythm

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Evidence Against the Role of Intracellular Calcium Dynamics in Ventricular Fibrillation

Cited by 4 publications

References 6 publications

Rotors and the Dynamics of Cardiac Fibrillation

Rotors and the Dynamics of Cardiac Fibrillation

Deciphering Arrhythmia Mechanisms: Tools of the Trade

Atrial fibrillation: The mother rotor and its rebellious offspring take turns sustaining the family

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