Evidence against a contribution of conventional urine risk factors to de novo ESRD renal stones

Stankus, Nicole; Worcester, Elaine M.; Hammes, Mary; Coe, Fredric L.

doi:10.1093/ndt/gfi302

Cited by 2 publications

(3 citation statements)

References 29 publications

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“…12 This different stone composition suggests that stone formation in ESRD HD patients develops via a different mechanism therefore different risk factors may be involved in stone formation in this particular population. [6][7][8][9] Suggested risk factors for matrix stones formation are low urine output, hyperuricemia, ß2 microglobulin, high Tamm Horsfall protein content and duration of dialysis. 12,13 Other risk factors include recurrent infections, high BMI, proteinuria and previous history of glomerulonephritis.…”

Section: Cuaj -Original Researchmentioning

confidence: 99%

“…These findings differ from the results of a study by Stankus et al in which stone former dialysis patients had similar serum uric acid levels compared to non-stone formers (6.9 vs. 6.2 mg/L, p > 0.05). 8 However, that study relied on patient questionnaires rather than review of imaging studies that was performed in the present study. In addition, the Stankus et al study included only patients of African-American decent whereas the current study includes patients from all races.…”

Section: Hesswani Et Al Risk Factors For Stone Development In Esrdmentioning

confidence: 99%

“…6,7 Therefore, stone development in patients with ESRD on HD may be associated with risk factors different than those involved in stone formation in non-ESRD patients. 8,9 However, there is no literature regarding risk factors for de novo nephrolithiasis in this population. Therefore, the aim of the present study was to assess the incidence and risk factors for de novo nephrolithiasis in patients with ESRD on hemodialysis.…”

Section: Introductionmentioning

confidence: 99%

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Identifying risk factors for development of nephrolithiasis in end-stage renal disease patients

Hesswani

Iqbal

Zand

et al. 2019

CUAJ

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Introduction: We sought to assess the incidence and risk factors for stone development in patients with end-stage renal disease (ESRD) on hemodialysis (HD). Methods: Medical records of patients receiving HD between 2007 and 2017 were retrospectively reviewed. Patients who had been on HD for at least three months and had imaging studies (computed tomography [CT] scans or ultrasound [US]) pre- and post-initiation of HD were included. Exclusion criterion was presence of stones pre-HD. De novo stones were defined as renal stones found on followup imaging. Demographics, laboratory data, comorbidities, and dialysis characteristics were compared between non-stone-formers and stone-formers using propensity score matching. Results: A total of 133 patients met the inclusion criteria. Their median age was 68.5 years, median body mass index 28.7 kg/m2, and median dialysis duration 59.5 months. After HD, 14 (10.5%) patients developed de novo stones and their median dialysis-to-stone duration was 23.5 months. When compared with non-stone-formers, stone-formers had significantly lower incidence of hypertension (48.2% vs. 14.3%; p=0.03), lower serum ionized calcium (1.16 vs. 1.07 mmol/L; p=0.01) and magnesium (0.95 vs. 0.81 mmol/L; p=0.01), and significantly higher serum uric acid (281.5 vs. 319.0 mmol/L; p=0.03). Multivariate analysis demonstrated that lower serum ionized calcium (adjusted odds ratio [OR] 0.00001; 95% confidence interval [CI] 0–0.18) and magnesium (adjusted OR 0.0003; 95% CI 0–0.59) were significantly associated with stone formation. Conclusions: The incidence of de novo nephrolithiasis in ESRD patients on HD was 10.5%. Increased serum uric acid, decreased serum magnesium and ionized calcium, and absence of hypertension were associated with increased stone-formation in ESRD patients on HD.

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Section: Cuaj -Original Researchmentioning

confidence: 99%

Section: Hesswani Et Al Risk Factors For Stone Development In Esrdmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Identifying risk factors for development of nephrolithiasis in end-stage renal disease patients

Hesswani

Iqbal

Zand

et al. 2019

CUAJ

View full text Add to dashboard Cite

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Current World Literature

2007

Current Opinion in Nephrology &Amp; Hypertension

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Evidence against a contribution of conventional urine risk factors to de novo ESRD renal stones

Abstract: Usual stone risk factors did not correlate with new stones during dialysis.

Cited by 2 publications

References 29 publications

Identifying risk factors for development of nephrolithiasis in end-stage renal disease patients

Identifying risk factors for development of nephrolithiasis in end-stage renal disease patients

Current World Literature

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