Everyday Memory in Microsurgically Treated Patients After Subarachnoid Hemorrhage

Koso, Maida; Dizdarević, Kemal; Sose-Selimotic, Jasmina

doi:10.14740/jocmr2073w

Cited by 8 publications

(8 citation statements)

References 28 publications

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“…The prevalence of cognitive decline and CV is high in surviving aneurysmal SAH patients. Patients who survive SAH surgery often display functional deficits in addition to long-term memory deficits [ 90 ]. SAH symptoms have proven difficult to prevent; however, an effective treatment algorithm can improve outcome and increase quality of life for surviving SAH patients.…”

Section: Targeting Neuroinflammationmentioning

confidence: 99%

Aneurysmal Subarachnoid Hemorrhage and Neuroinflammation: A Comprehensive Review

Lucke‐Wold

Logsdon

Manoranjan³

et al. 2016

IJMS

249

181

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Aneurysmal subarachnoid hemorrhage (SAH) can lead to devastating outcomes including vasospasm, cognitive decline, and even death. Currently, treatment options are limited for this potentially life threatening injury. Recent evidence suggests that neuroinflammation plays a critical role in injury expansion and brain damage. Red blood cell breakdown products can lead to the release of inflammatory cytokines that trigger vasospasm and tissue injury. Preclinical models have been used successfully to improve understanding about neuroinflammation following aneurysmal rupture. The focus of this review is to provide an overview of how neuroinflammation relates to secondary outcomes such as vasospasm after aneurysmal rupture and to critically discuss pharmaceutical agents that warrant further investigation for the treatment of subarachnoid hemorrhage. We provide a concise overview of the neuroinflammatory pathways that are upregulated following aneurysmal rupture and how these pathways correlate to long-term outcomes. Treatment of aneurysm rupture is limited and few pharmaceutical drugs are available. Through improved understanding of biochemical mechanisms of injury, novel treatment solutions are being developed that target neuroinflammation. In the final sections of this review, we highlight a few of these novel treatment approaches and emphasize why targeting neuroinflammation following aneurysmal subarachnoid hemorrhage may improve patient care. We encourage ongoing research into the pathophysiology of aneurysmal subarachnoid hemorrhage, especially in regards to neuroinflammatory cascades and the translation to randomized clinical trials.

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Section: Targeting Neuroinflammationmentioning

confidence: 99%

Aneurysmal Subarachnoid Hemorrhage and Neuroinflammation: A Comprehensive Review

Lucke‐Wold

Logsdon

Manoranjan³

et al. 2016

IJMS

249

181

View full text Add to dashboard Cite

show abstract

“…As many cases of aSAH occur at a relatively young age with peak incidence at 55 years of age, many survivors are faced with limitations in their everyday life for decades [1][2][3][4]. Besides physical impairments, neuropsychological deficits have been recognized as one of the main factors affecting patient's quality of life; however, even though many outcome assessment tools like the Montreal Cognitive Assessment (MoCA) and the Mini-Mental Status Evaluation (MMSE), different memory tests like the Wechsler Memory Scale or the California Verbal Learning Test as well as tests of executive function, such as the Wisconsin Card Sorting Task, have been evaluated, it has been difficult to recognize subtle cognitive deficits by means of gross neurological measures [5][6][7][8][9][10]. Therefore, it is the goal of the current study to evaluate the feasibility of administering the Neuropsychological Assessment Battery screening module (NAB-S) to patients with aSAH.…”

Section: Introductionmentioning

confidence: 99%

The neuropsychological assessment battery (NAB) is a valuable tool for evaluating neuropsychological outcome after aneurysmatic subarachnoid hemorrhage

et al. 2020

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Background Detecting and treating neuropsychological deficits after aneurysmatic subarachnoid hemorrhage (aSAH) play a key role in regaining independence; however, detecting deficits relevant to social and professional reintegration has been difficult and optimal timing of assessments remains unclear. Therefore, we evaluated the feasibility of administering the Neuropsychological Assessment Battery screening module (NAB-S) to patients with aSAH, assessed its value in predicting the ability to return to work and characterized clinical as well as neuropsychological recovery over the period of 24 months. Methods A total of 104 consecutive patients treated for aSAH were recruited. After acute treatment, follow up visits were conducted at 3, 12 and 24 months after the hemorrhage. NAB-S, Montreal Cognitive Assessment (MoCA) and physical examination were performed at each follow up visit. Results The NAB-S could be administered to 64.9, 75.9 and 88.9% of the patients at 3, 12 and 24 months, respectively. Moderate impairment of two or more neuropsychological domains (e.g speech, executive function, etc.) significantly correlated with inability to return to work at 12 and 24 months as well as poor outcome assessed by the extended Glasgow Outcome Scale (GOSE) at 3, 12 and 24 months. The number of patients with favorable outcomes significantly increased from 25.5% at discharge to 56.5 and 57.1% at 3 and 12 months, respectively, and further increased to 74.1% after 24 months. Conclusion The NAB-S can be administered to the majority of patients with aSAH and can effectively detect clinically relevant neuropsychological deficits. Clinical recovery after aSAH continues for at least 24 months after the hemorrhage which should be considered in the design of future clinical trials.

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“…In our study, we assessed cognitive functioning using the CFQ and TICS-M questionnaires, both of which are validated tools that have been previously used in patients with aneurysmal SAH. 9 , 21 The TICS-M provides an objective measure of global cognitive functioning, whereas the CFQ provides subjective patient-reported accounts of failures in perception, memory, and motor function in everyday life. Our results demonstrated that the two surgical approaches performed similarly on the CFQ and TICS-M.…”

Section: Discussionmentioning

confidence: 99%

Cognitive Outcomes After Anterior Communicating Artery Aneurysm Repair

Nassiri

Workewych

Badhiwala

et al. 2018

Can. J. Neurol. Sci.

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Background The long-term cognitive and quality-of-life (QoL) outcomes after treatment of ruptured anterior communicating artery (ACoA) aneurysms are unknown. Methods Potential participants were all consecutive patients with ruptured ACoA aneurysms who were treated at one institution from July 1992 to December 2008. All potential participants were asked to complete the Cognitive Failures Questionnaire (CFQ), Center for Epidemiology Studies-Depression (CES-D) questionnaire, Short Form 36 (SF-36) questionnaire, and Telephone Interview for Cognitive Status-Modified (TICS-M). Patient charts were retrospectively reviewed for baseline demographics and clinical status, intra-operative details, and post-operative course. Reporting of cognitive and QoL assessment results was stratified by treatment method (endovascular coil embolization and surgical clipping by pterional craniotomy or orbitocranial craniotomy). Results In total, 82 patients (18 treated with coiling, 27 by orbitocranial craniotomy, and 37 by pterional craniotomy) were included in this study. In total, 32 patients (9 treated by coiling, 11 by orbitocranial craniotomy, and 16 by pterional craniotomy) completed follow-up cognitive and QoL questionnaires. The mean follow-up for patients who completed the questionnaires was 8.64±3.81 years. The three groups did not differ in questionnaires assessing cognitive status (TICS-M p=0.114, CFQ p=0.111). Moreover, there were no observed differences in QoL or depression scores between the three groups. Conclusions At long-term follow-up, QoL, cognitive, and depression test scores of patients with ruptured ACoA aneurysms are similar across open surgery and coiling modalities. Our results emphasize the importance of considering long-term outcomes with validated daily measures of functioning when reporting on outcomes after treatment for ruptured intracranial aneurysms. Larger prospective studies are required to further explore the results.

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Everyday Memory in Microsurgically Treated Patients After Subarachnoid Hemorrhage

Cited by 8 publications

References 28 publications

Aneurysmal Subarachnoid Hemorrhage and Neuroinflammation: A Comprehensive Review

Aneurysmal Subarachnoid Hemorrhage and Neuroinflammation: A Comprehensive Review

The neuropsychological assessment battery (NAB) is a valuable tool for evaluating neuropsychological outcome after aneurysmatic subarachnoid hemorrhage

Cognitive Outcomes After Anterior Communicating Artery Aneurysm Repair

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