Everyday Cognition in Older Adults: Associations with Neuropsychological Performance and Structural Brain Imaging

Farias, Sarah E Tomaszewski; Park, Lovingly Quitania; Harvey, Danielle; Simon, Christa; Reed, Bruce R; Carmichael, Owen; Mungas, Dan M

doi:10.1017/s1355617712001609

Cited by 92 publications

(91 citation statements)

References 57 publications

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“…The ECog has been shown to have excellent internal reliability (Cronbach’s alpha = 0.97) as well as good test re-test reliability (r=.82, p<.001) (6). Various aspects of validity have been demonstrated via its correlation with other well-known measures of daily function (6), as well as cognitive and neuroimaging indicators of disease (6, 29). Finally, the ECog has been shown to be sensitive to change over time and shows differential rates of change in relation to baseline diagnosis and change in diagnosis over follow-up (4).…”

Section: Methodsmentioning

confidence: 99%

Self‐rated and informant‐rated everyday function in comparison to objective markers of Alzheimer's disease

Rueda

Lau

Saito

et al. 2014

Alzheimer's & Dementia

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It is recognized that individuals with mild cognitive impairment (MCI) already demonstrate difficulty in aspects of daily functioning, which predicts disease progression. This study examined the relationship between self- versus informant-report of functional ability, and how those reports relate to objective disease measures across the disease spectrum (i.e. cognitively normal, MCI, Alzheimer’s disease). A total of 1,080 subjects with self- and/or informant-rated Everyday Cognition (ECog) questionnaires were included. Objective measures included cognitive functioning, structural brain atrophy, cerebrospinal fluid (CSF) abnormalities, and a marker of amyloid deposition using positron emission tomography (PET) with [18F]AV45 (florbetapir). Overall, informant-report was consistently more associated with objective markers of disease than self-report although self-reported functional status may still have some utility in early disease.

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Section: Methodsmentioning

confidence: 99%

Self‐rated and informant‐rated everyday function in comparison to objective markers of Alzheimer's disease

Rueda

Lau

Saito

et al. 2014

Alzheimer's & Dementia

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“…Persons with relatively low cognitive function may place a lower value on good vision, e.g., read less often, 24 be less future-oriented or be less able to comprehend the potential consequences of not getting recommended care. 25 …”

Section: Methodsmentioning

confidence: 99%

Gaps in Receipt of Regular Eye Examinations among Medicare Beneficiaries Diagnosed with Diabetes or Chronic Eye Diseases

2014

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Objective To examine a wide range of factors associated with regular eye exam receipt among elderly individuals diagnosed with glaucoma, age-related macular degeneration, or diabetes mellitus (DM). Design Retrospective analysis of Medicare claims linked to survey data from the Health and Retirement Study (HRS). Participants The sample consisted of 2,151 Medicare beneficiaries who responded to the HRS. Methods Medicare beneficiaries with at least 1 of the 3 study diagnoses were identified by diagnosis codes and merged with survey information. The same individuals were followed over 5 years divided into 4 15-month periods. Predictors of the number of periods with an eye exam evaluated were beneficiary demographic characteristics, income, health, cognitive, and physical function, health behaviors, subjective beliefs about longevity, the length of the individual’s financial planning horizon, supplemental health insurance coverage, eye disease diagnoses and low vision/blindness at baseline. We performed logit analysis of the number of 15-month periods in which beneficiaries received an eye exam. Main Outcome Measures The primary outcome measure was the number of 15-month periods with an eye examination. Results Only one third of beneficiaries with the study’s chronic diseases saw an eye care provider in all 4 follow-up periods despite having Medicare. A quarter only obtained an eye exam at most during 1 of the 4 15-month follow-up periods. Among the 3 groups of patients studied, utilization was particularly low for persons with diagnosed DM and no eye complications. Age, marriage, education and a higher score on the Charlson index were associated with more periods with an eye exam. Male gender, being limited in Instrumental Activities of Daily Living at baseline, distance to the nearest ophthalmologist, and low cognitive function were associated with a reduction in frequency of eye exams. Conclusions Rates of eye exams for elderly persons with DM or frequently occurring eye diseases, especially for DM, remain far below recommended levels in a nationally representative sample of persons with health insurance coverage. Several factors, including limited physical and cognitive function, and greater distance to an ophthalmologist, but not health insurance coverage, account for variation in regular use.

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“…This instrument has been validated in MCI and AD samples, and informant-report on this measure has been shown to correlate with established measures of functional abilities and global cognition (Farias et al, 2008). In addition, a recent study found that fewer informantreported problems on the ECog was associated with better performance on neuropsychological testing, particularly on measures of memory and executive function, and larger brain volumes in the hippocampus, dorsolateral prefrontal cortex, and total brain (Farias et al, 2013).…”

Section: Subjective Cognitive Complaintsmentioning

confidence: 99%

P1‐340: Subjective Cognitive Complaints Contribute to Misdiagnosis of Mild Cognitive Impairment

Edmonds

Delano‐Wood

Galasko

et al. 2014

Alzheimer's & Dementia

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Subjective cognitive complaints are a criterion for the diagnosis of mild cognitive impairment (MCI), despite their uncertain relationship to objective memory performance in MCI. We aimed to examine self-reported cognitive complaints in subgroups of the Alzheimer's Disease Neuroimaging Initiative (ADNI) MCI cohort to determine whether they are a valuable inclusion in the diagnosis of MCI or, alternatively, if they contribute to misdiagnosis. Subgroups of MCI were derived using cluster analysis of baseline neuropsychological test data from 448 ADNI MCI participants. Cognitive complaints were assessed via the Everyday Cognition (ECog) questionnaire, and discrepancy scores were calculated between self-and informant-report. Cluster analysis revealed Amnestic and Mixed cognitive phenotypes as well as a third Cluster-Derived Normal subgroup (41.3%), whose neuropsychological and cerebrospinal fluid (CSF) Alzheimer's disease (AD) biomarker profiles did not differ from a "robust" normal control group. This cognitively intact phenotype of MCI participants overestimated their cognitive problems relative to their informant, whereas Amnestic MCI participants with objective memory impairment underestimated their cognitive problems. Underestimation of cognitive problems was associated with positive CSF AD biomarkers and progression to dementia. Overall, there was no relationship between self-reported cognitive complaints and objective cognitive functioning, but significant Correspondence and reprint requests to: Mark W. Bondi, PhD, Psychology Service (116B), VA San Diego, Healthcare System, 3350 La Jolla Village Drive, San Diego, CA 92161. mbondi@ucsd.edu. * Data used in preparation of this article were obtained from the Alzheimer's Disease Neuroimaging Initiative (ADNI) database (http:// adni.loni.usc.edu). As such, the investigators within the ADNI contributed to the design and implementation of the ADNI and/or provided data but did not participate in analysis or writing of this article. A complete listing of ADNI investigators can be found at http://adni.loni.usc.edu/wp-content/uploads/how_to_apply/ADNI_Acknowledgement_List.pdf. Conflict of Interest

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Everyday Cognition in Older Adults: Associations with Neuropsychological Performance and Structural Brain Imaging

Cited by 92 publications

References 57 publications

Self‐rated and informant‐rated everyday function in comparison to objective markers of Alzheimer's disease

Self‐rated and informant‐rated everyday function in comparison to objective markers of Alzheimer's disease

Gaps in Receipt of Regular Eye Examinations among Medicare Beneficiaries Diagnosed with Diabetes or Chronic Eye Diseases

P1‐340: Subjective Cognitive Complaints Contribute to Misdiagnosis of Mild Cognitive Impairment

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