Everolimus for neurological and psychiatric diseases: Friend or foe?

Pediatric low-grade gliomas: a brave new world

“…6 Similarly, germline mutations in phosphatase and tensin homolog are associated with autism spectrum disorders, 7 and mammalian target of rapamycin inhibition with everolimus has pleiotropic effects on cognition and mental health. 8 Thus, we can expect that targeted inhibition of these pathways is likely to affect cognitive development, function, and behavior. There is a chance that these drugs will improve these functions, but regardless, we will need to rigorously characterize the effects and, over time, their long-term consequences.…”