Abstract:Abstract:The treatment of patients with advanced renal cell carcinoma (RCC) has been revolutionized by the development of agents directed against vascular endothelial growth factor (VEGF) signaling. These agents, such as sorafenib and sunitinib, have been advocated as first-line treatments for RCC. However, responses to these agents are neither complete nor durable and nearly all patients will require second-line therapy. Everolimus (RAD001) is an oral inhibitor of mammalian target of rapamycin (mTOR) which ha… Show more
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