Everolimus But Not Mycophenolate Mofetil Therapy Is Associated With Soluble HLA-G Expression in Heart Transplant Patients

Sheshgiri, Rohit; Gustafsson, Finn; Sheedy, Jill; Rao, Vivek; Ross, Heather J.; Delgado, Diego

doi:10.1016/j.healun.2009.07.009

Cited by 26 publications

(17 citation statements)

References 41 publications

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“…It was found that the HLA-G 14 bp insertion polymorphism in the 3´UTR is responsible for a decrease in the mRNA level of most membrane and soluble isoforms [15]. The possible impact of the HLA-G 14 bp variant on kidney graft be up-regulated by stressors such as hypoxia, cytokines like IFN-g, TNF, IL-10, TGF-b, immunosuppressive agents or progressive doses of progesterone [34,35]. In relation to HLA-G expression, the time-course of serum HLA-G in patients after kidney transplantation has been examined by only few studies to date [18,31].…”

Section: Discussionmentioning

confidence: 99%

Impact of HLA-G 14 bp polymorphism and soluble HLA-G level on kidney graft outcome

Ďurmanová

Bandžuchová²,

Žilinská

et al. 2016

Open Life Sciences

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Human leukocyte antigen G (HLA-G) is a non-classical HLA class I protein with various immunosuppressive functions. Besides its profound effect to induce fetal tolerance, HLA-G has been also found to enhance graft acceptance. The aim of the study was to analyse the association between HLA-G 14 bp insertion/deletion polymorphism, soluble HLA-G level and kidney graft outcome in the Slovak population. We investigated 69 kidney transplant recipients aged 27–65 years. Out of this group, 37 recipients developed acute rejection, confirmed by biopsy, and 32 patients had stable allograft function. Plasma was obtained from recipients at 1 day before transplantation and analyzed by ELISA. Genotyping of HLA-G polymorphism was performed by PCR. Significantly higher pre-transplantation levels of sHLA-G were found in the group with stable allograft function in comparison to group with acute rejection (P = 0.0409). In the homozygous −14/−14 recipients with stable allograft function, significantly higher values of sHLA-G were determined in comparison to the recipients with acute rejection (P = 0.0052). The study revealed an association between 14 bp deletion polymorphism and soluble HLA-G level that is proportional to kidney graft acceptance. It is suggested that pre-transplantation levels of soluble HLA-G should be monitored as additional marker to predict kidney graft outcome.

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Section: Discussionmentioning

confidence: 99%

Impact of HLA-G 14 bp polymorphism and soluble HLA-G level on kidney graft outcome

Ďurmanová

Bandžuchová²,

Žilinská

et al. 2016

Open Life Sciences

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“…The mechanism of the increased HLA-G expression after allo-HSCT was still unclear, which might be partly attributed to the application of G-CSF in our study. Sheshgiri et al [47] observed that everolimus might induce the expression of sHLA-G in heart transplant patients. In the present study, univariate and multivariate analysis revealed that the levels of sHLA-G in patients after transplantation were not related to the prophylaxis regimens for GVHD.…”

Section: Discussionmentioning

confidence: 99%

Soluble Human Leukocyte Antigen G Molecule Expression in Allogeneic Hematopoietic Stem Cell Transplantation: Good Predictor of Acute Graft-versus-Host Disease

et al. 2013

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Background: Graft-versus-host disease (GVHD) remains a main complication of allogeneic hematopoietic stem cell transplantation (allo-HSCT). Human leukocyte antigen G (HLA-G) is a non-classical class I molecule exerting multiple immunoregulatory functions. The aim of this study was to explore the relationship between soluble HLA-G (sHLA-G) and GVHD after allo-HSCT. Methods: The sHLA-G levels were examined using enzyme-linked immunosorbent assay in patients with hematological malignancies (n = 106) before transplantation, on days +15 and +30 after transplantation, as well as healthy volunteers (n = 10). Results: The levels of sHLA-G5, sHLA-G6 and sHLA-G7 in patients on days +15 and +30 after transplantation were all significantly higher than those before transplantation (all p ≤ 0.001). The increased levels of sHLA-G5 on days +15 and +30 after transplantation were both significantly higher in patients with grade 0-I acute GVHD (aGVHD) compared to those with grade II-IV aGVHD (both p < 0.001). The increased levels of sHLA-G5 on days +15 and +30 after transplantation were both negatively correlated with the severity of aGVHD (both p < 0.001). Conclusion: sHLA-G5 might be a predictor of the occurrence and severity of aGVHD, which may help to establish individual prophylaxis against aGVHD and improve the survival for patients after allo-HSCT.

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“…1,12,13,19 Therefore, we decided to investigate if there was a genetic component influencing HLA-G expression that would reliably identify patients at risk for developing rejection.…”

Section: Discussionmentioning

confidence: 99%

“…Acute cellular rejections were scored according to the International Society for Heart and Lung Transplantation (ISHLT) classification system. 19 Serial myocardial biopsies were performed weekly during the first month, bi-weekly for 3 months, monthly for 6 months, and finally, every 3 months during the first year after transplantation.…”

Section: Patientsmentioning

confidence: 99%

The 14-bp deletion in the HLA-G gene indicates a low risk for acute cellular rejection in heart transplant recipients

Twito

Joseph

Mociornita

et al. 2011

The Journal of Heart and Lung Transplantation

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Everolimus But Not Mycophenolate Mofetil Therapy Is Associated With Soluble HLA-G Expression in Heart Transplant Patients

Cited by 26 publications

References 41 publications

Impact of HLA-G 14 bp polymorphism and soluble HLA-G level on kidney graft outcome

Impact of HLA-G 14 bp polymorphism and soluble HLA-G level on kidney graft outcome

Soluble Human Leukocyte Antigen G Molecule Expression in Allogeneic Hematopoietic Stem Cell Transplantation: Good Predictor of Acute Graft-versus-Host Disease

The 14-bp deletion in the HLA-G gene indicates a low risk for acute cellular rejection in heart transplant recipients

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