Event-related potentials (P300) and neuropsychological assessment in boys exhibiting Duchenne muscular dystrophy

Abstract

-Objective: To examine auditory cognitive evoked potentials (P300 potentials) and neuropsychological dysfunction in patients with Duchenne muscular dystrophy (DMD). Method: P300 potentials and neuropsychological test results were obtained from 16 healthy control boys and 20 DMD patients. Full Intelligence Quotients (IQ) were estimated for patients and control group. Mean age was 9.5 years in the DMD patient group, and 10 years in the control group (p>0.05). Results: The mean IQ values were 64.35 in the DMD patients and 82.68 in the control group (p=0.01). Mean P300 values were 347.6 in the DMD group and 337.4 in the control group (p=0.14). There was no significant correlation between parameters in each group. Conclusion: DMD patients showed a poor performance as evaluated by P300 potential compared to the control group, although the difference was not statistically significant. Systematic alterations in neuropsychological test results were found, the differences paralleling those detected in IQ.

Event-Related Potentials (P300 - MMN) and Neuropsychological Assessment in Duchenne Muscular Dystrophy Patients

“…In the literature, there is only one study that evaluated P300 in DMD patients. Della Coletta et al, [18] found poor performance in DMD patients as evaluated by P300 potential compared to the control group, although the difference was not statistically significant. In the present study, the researchers found no statistical difference in mean P300 values between the groups.…”

“…Although studies on the cognitive functions in DMD patients with neuropsychological tests are many, there is only one neurophysiologic evaluation [18]. The aim of this study is to evaluate DMD patients with electrophysiological (MMN and P300) and neuropsychological tests to demonstrate neurocognitive impairment.…”

Applicability of the P300 frequency pattern test to assess auditory processing

“…All the P300 tests found in the literature used the oddball paradigm, with 80% of frequent stimuli (FS) and 20% of rare stimuli (RS). The frequency used for the FS was 1000 Hz 14 , 21 , 30 , 35 , 38 , 39 , 40 , 41 , 42 , 43 , 44 and 2000 Hz 14 , 30 , 31 , 32 , 33 , 34 , 39 , 40 , 42 , 43 , 44 was used for the RS with four studies using 1500 Hz 21 , 36 , 38 , 43 .…”

“…To implement the test, we mentioned the use of the Nuprep Abrasive Skin Gel cleaning paste on the skin 32 , the OMNI 34 abrasive paste and the Every Per La Pulizia Della Cute 36 - electrolytic paste for better electric current conductivity 32 , 33 and the electrode was secured with micropore tape 31 , 33 , 41 , 42 . To facilitate relaxation during the exam, he had a quiet 21 , 36 , 41 , semi dark 14 , 34 , 36 room, with a reclining chair 21 , 41 , 43 or a stretcher 14 , 36 , 42 .…”

“…The electrodes were placed on the mastoid and vertex 43 , but also placed on the vertex (Cz), frontal (Fz) and mastoid (A1 and A2) 21 , 30 , 31 , 33 , 39 , 41 , yet a considerable part of the studies used the international system 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 in which the electrodes are placed on the forehead (Fz), vertex (Cz), parietal (Pz) and earlobes (A1 - left, A2 - right) 14 , 34 , 35 , 36 , 42 , 43 , 44 . In one study they added to the international way of electrode placement 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , one electrode above the right eyebrow and one in the left corner of the eye to control the electrooculogram 40 .…”