Event-related potentials — neurophysiological tools for predicting emergence and early outcome from traumatic coma

Kane, Nick; Curry, Stephen H.; Rowlands, C.A.; Manara, Alex; Lewis, Terri L.; Moss, T. H.; Cummins, Brian H.; Butler, S.R.

doi:10.1007/bf01728329

Cited by 160 publications

(74 citation statements)

References 36 publications

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“…The MMN has been used to demonstrate that consciousness may be about to return in comatose patients [Kane et al, 1996]. This is and exciting finding.…”

Section: Disorders Of Consciousnessmentioning

confidence: 97%

Mismatch Negativity: Different Water in the Same River

Picton

Alain

Otten³

et al. 2000

Audiol Neurotol

533

364

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The mismatch negativity (MMN) is a frontal negative deflection in the human event-related potential that typically occurs when a repeating auditory stimulus changes in some manner. The MMN can be elicited by many kinds of stimulus change, varying from simple changes in a single stimulus feature to abstract changes in the relationship between stimuli. The main intracerebral sources for the MMN are located in the auditory cortices of the temporal lobe. Since it occurs whether or not stimuli are being attended, the MMN represents an automatic cerebral process for detecting change. The MMN is clinically helpful in terms of demonstrating disordered sensory processing or disordered memory in groups of patients. Improvements in the techniques for measuring the MMN and in the paradigms for eliciting it will be needed before the MMN can become clinically useful as an objective measurement of such disorders in individual patients.

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“…The MMN has been used to demonstrate that consciousness may be about to return in comatose patients [Kane et al, 1996]. This is and exciting finding.…”

Section: Disorders Of Consciousnessmentioning

confidence: 97%

Mismatch Negativity: Different Water in the Same River

Picton

Alain

Otten³

et al. 2000

Audiol Neurotol

533

364

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“…It assesses the residual brain activity and more specifically the integrity of echoic memory, a memory that permits a sound to be remembered in the 2 or 3 s after it is heard. The presence of MMN has prognostic value in predicting recovery after coma (Kane et al 1996;Fischer et al 2004;Naccache et al 2005;Qin et al 2008).…”

Section: Long-latency Cognitive Erpsmentioning

confidence: 99%

Disorders of Consciousness: Coma, Vegetative and Minimally Conscious States

Gosseries

Vanhaudenhuyse

Bruno

et al. 2011

The Frontiers Collection

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Consciousness can be defined by two components: arousal and awareness. Disorders of consciousness (DOC) are characterized by a disrupted relationship between these two components. Coma is described by the absence of arousal and, hence, of awareness whereas the vegetative state is defined by recovery of arousal in the absence of any sign of awareness. In the minimally conscious state, patients show preserved arousal level and exhibit discernible but fluctuating signs of awareness. The study of DOC offers unique insights to the neural correlates of consciousness. We here review the challenges posed by the clinical examination of DOC patients and discuss the contribution of functional neuroimaging and electrophysiological techniques to the bedside assessment of consciousness. These studies raise important issues not only from a clinical and ethical perspective (i.e. diagnosis, prognosis and management of DOC patients) but also from a neuroscientific standpoint, as they enrich our current understanding of the emergence and function of the conscious mind.

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“…MMN is a component of negative polarity of scalp-recorded event-related potentials (ERPs) at about 150-200 ms poststimulus (Näätänen et al, 1978;Näätänen, 1990). MMNs observed even in comatose (Kane et al, 1996) and generally anesthetized (Koelsch et al, 2006) adults as well as sleeping infants (e.g., Alho et al, 1986) suggest that MMN is also reasonably independent from the awake behavioral state.…”

Section: Introductionmentioning

confidence: 99%