Event-related potentials in patients with olfactory loss

Brämerson, Annika; Millqvist, Eva; Ydse, Bo; Larsson, Christel; Olofsson, Jonas; Bende, Mats

doi:10.1080/00016480801891702

Cited by 8 publications

(13 citation statements)

References 19 publications

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“…However, our results demonstrate that the presence of oERPs in IOL is more common than previously found: 60% of IOL patients in our study were classified as having functional hyposmia rather than functional anosmia. Indeed, oERPs can be observed in most patients with hyposmia, and the probability of detecting an oERP becomes greater as hyposmia is less severe . In addition, a fraction of patients with the diagnosis “functional anosmia” do occasionally experience olfactory sensations or are able to identify certain odors .…”

Section: Discussionmentioning

confidence: 99%

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Evaluation of idiopathic olfactory loss with chemosensory event‐related potentials and magnetic resonance imaging

Liu

Pinto

Yang

et al. 2018

Int Forum Allergy Rhinol

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BackgroundIdiopathic olfactory loss (IOL) accounts for a sizable fraction of olfactory dysfunction, but very little is known about its etiology and electrophysiological changes in the olfactory pathway.MethodsWe analyzed the physiology of IOL using chemosensory event‐related potentials (ERPs) (olfactory and trigeminal: oERP and tERP) and olfactory pathway magnetic resonance imaging (MRI) measured in adult patients with IOL and healthy controls. Subjective olfactory function was measured by Toyota and Takagi (T&T) olfactometry and Sniffin’ Sticks (SS).ResultsOlfactory function was worse in patients with IOL compared to controls (T&T, p < 0.001; SS, p < 0.001). oERPs could be evoked in 17 IOL patients. Signals in these patients showed lower amplitude in the N1 and P2 waves than controls (p < 0.05 for both), but there were no difference in latency between the 2 groups (p > 0.05). tERP were detected in all patients and controls; there were no differences in latency and nor amplitude between the 2 groups (p > 0.05). The olfactory bulb (OB) volume was significantly smaller in the IOL group than controls (p < 0.001), but there was no difference in the olfactory sulcus depth between groups (p > 0.05). Better olfactory function was associated with increasing magnitude of N1 amplitude in oERPs (p < 0.05) and increasing OB volume (p < 0.05).ConclusionIOL patients show neurophysiologic deficits and some anatomic differences compared to healthy controls.

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Section: Discussionmentioning

confidence: 99%

“…The amplitudes of the N 1 and P 2 components were defined separately as peak‐to‐baseline amplitudes. ERPs (both oERPs and tERPs) were considered as present if the averaged waveforms demonstrated a negative‐positive complex with the amplitude value exceeding ±2 μV within the latency windows …”

Section: Methodsmentioning

confidence: 99%

Evaluation of idiopathic olfactory loss with chemosensory event‐related potentials and magnetic resonance imaging

Liu

Pinto

Yang

et al. 2018

Int Forum Allergy Rhinol

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“…Our data showed that postponed latency and reduced amplitude of N1 and P2 waves of oERPs were observed in patients with functional anosmia in this study when compared to healthy subjects; the results demonstrated clear changes in oERPs under dysosmia and suggest a possible application of this method in clinical diagnosis in Chinese populations. Braemerson et al [14] showed that patients with dysosmia had prolonged latency and reduced amplitude of oERPs when compared to healthy subjects. Similar trends were observed in our study.…”

Section: Discussionmentioning

confidence: 99%

Examination of chemosensory functions in patients with dysosmia

Yang

Wei

Zhang³

et al. 2012

Med Sci Monit

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SummaryBackgroundTo examine changes of chemical sensory functions in patients with dysosmia.Material/MethodsThe 272 study subjects included 98 healthy volunteers, 86 subjects with hyposmia and 88 subjects with functional anosmia. Their chemical sensory functions were examined using olfactory event-related potentials (oERPs), trigeminal event-related potentials (tERPs), T&T olfactometer and triple drop method, respectively.ResultsThe T&T results showed that the difference between patients and healthy subjects had statistical significance. The oERPs and tERPs results showed that patients with functional anosmia had N1 and P2 waves of prolonged latency and reduced amplitude when compared to healthy subjects with the difference of statistical significance. When compared to healthy subjects, patients with functional anosmia had clear hypogeusia and the difference had statistical significance. For the younger group there was significant difference between healthy subjects and patients in T&T, oERPs and tERPs results.ConclusionsIt is suggested by the apparently concomitant trigeminal nerve dysfunction and hypogeusia in patients with functional anosmia in this study that olfactory and nasal trigeminal function in young patients was clearly decreased. Our study suggests the possible application of oERPs, tERPs and three drops method in clinical diagnosis in Chinese populations and provides scientific evidence for treatment.

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“…There is discussion as to whether repeated stimulation or a shortening of the ISI may cause a reduction in amplitudes and latencies [4]. Therefore an ISI of 30Á60 s is usually used between the stimuli to avoid adaptation and/or habituation [4,5].…”

Section: Introductionmentioning

confidence: 99%

“…The more neurons activated or synchronized, the larger the amplitude of the signal obtained at the surface of the scalp [4]. One of the main characteristics of CSERPs is the dependence on stimulus intensity, which can be described as the number of molecules presented during a defined time segment [5].…”

Section: Introductionmentioning

confidence: 99%

Effects of short inter-stimulus intervals on olfactory and trigeminal event-related potentials

Kassab

Schaub

Vent

et al. 2009

Acta Oto-Laryngologica

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Event-related potentials in patients with olfactory loss

Abstract: The OERP amplitudes increased and the latencies shortened with increasing stimulus concentration. Furthermore, a difference between the groups was found, with higher OERP amplitudes and shorter latencies in healthy subjects compared with patients.

Cited by 8 publications

References 19 publications

Evaluation of idiopathic olfactory loss with chemosensory event‐related potentials and magnetic resonance imaging

Evaluation of idiopathic olfactory loss with chemosensory event‐related potentials and magnetic resonance imaging

Examination of chemosensory functions in patients with dysosmia

Effects of short inter-stimulus intervals on olfactory and trigeminal event-related potentials

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