Event-related potentials in drug-naïve pediatric patients with obsessive-compulsive disorder

Yamamuro, Kazuhiko; Ota, Toyosaku; Nakanishi, Yoko; Matsuura, Hiroki; Okazaki, Kosuke; Kishimoto, Naoki; Takahashi, Hiroyuki R.; Iwasaka, Hidemi; Iida, Junzo; Kishimoto, Toshifumi

doi:10.1016/j.psychres.2015.09.026

Cited by 14 publications

(26 citation statements)

References 45 publications

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“…Fourth, the MMN baseline interval used in our study was short, which might have reduced the reliability of the signal. However, our group has taken ERP measurements using this method during several investigations of psychiatric disorders,17,43,44 and these findings were consistent with those of our previous studies. Given these limitations, future studies should be conducted to determine whether abnormalities in the frontal lobe are resultant from or causative of altered functional connectivity.…”

Section: Discussionsupporting

confidence: 91%

Associations between the mismatch-negativity component and symptom severity in children and adolescents with attention deficit/hyperactivity disorder

Yamamuro¹,

Ota²,

Iida

et al. 2016

NDT

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AimCognitive impairment is an important predictor of functional outcome in patients with attention deficit/hyperactivity disorder (ADHD). However, the neurophysiology of ADHD-related cognitive impairments remains unclear. Event-related potentials (ERPs) represent the noninvasive measurement of neural correlates of cognitive function. Mismatch negativity (MMN) is an ERP component that is presumed to index the preattentive monitoring of changes in the auditory environment.Materials and methodsPrevious studies have shown altered MMN amplitude and latency in patients with ADHD. However, little is known about the relationship between MMN and ADHD-symptom severity. To address this, we measured the amplitude and latency of MMN in ERPs and assessed correlations with the clinical severity of ADHD, as measured by the ADHD Rating Scale IV – Japanese version. Participants were 51 treatment-naïve children and adolescents with ADHD (mean age 10.42±3.35 years) and 15 normally developing age- and sex-matched children (mean age 11.8±3.36 years).ResultsIn the ADHD group, MMN amplitudes were attenuated at the central electrode and MMN latencies prolonged at the parietal electrode (Pz) relative to those in the control group. Furthermore, MMN amplitudes at Pz were negatively correlated with ADHD full-scale and hyperactivity–impulsivity and inattention subscale scores, and MMN latency at Pz was positively correlated with ADHD hyperactivity–impulsivity subscale scores.ConclusionOur data suggest that MMN reflects the severity of ADHD symptoms in children and adolescents, and provides support for the use of ERPs in evaluating ADHD symptoms in patients.

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Section: Discussionsupporting

confidence: 91%

Associations between the mismatch-negativity component and symptom severity in children and adolescents with attention deficit/hyperactivity disorder

Yamamuro¹,

Ota²,

Iida

et al. 2016

NDT

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“…Fifth, the MMN baseline interval was short, which might have reduced the reliability of the signal. However, our group has taken ERPs measurements using this same method in several studies of psychiatric disorders (Sawada et al, 2010;Yamamuro et al, 2015;Yamamuro et al, 2016), and were consistent with other studies. Sixth, we found no correlations between ERP measures and task performance, despite finding an almost significant improvement in task performance in patients with ADHD after treatment.…”

Section: Discussionsupporting

confidence: 87%

“…The shortness does not prevent reliable measurements, and we have already used similar methods to examine ERPs in several psychiatric disorders (Sawada et al, 2010;Yamamuro et al, 2015;Yamamuro et al, 2016).…”

Section: Recording and Analysesmentioning

confidence: 99%

“…Event-related potentials (ERPs) are commonly used as a noninvasive physiological measure of cognitive dysfunction associated with several psychiatric disorders, including ADHD (Johnstone et al, 2013), obsessive-compulsive disorder (OCD) (Yamamuro et al, 2015), and at-risk mental state (Bramon et al, 2008). ERP amplitudes contain a number of characteristic peaks and troughs that correspond to certain underlying processes.…”

Section: Introductionmentioning

confidence: 99%

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Event-related potentials reflect the efficacy of pharmaceutical treatments in children and adolescents with attention deficit/hyperactivity disorder

Yamamuro

Ota

Iida

et al. 2016

Psychiatry Research

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“…Event-related potentials (ERPs) are commonly used as a physiological measure of cognitive function, as they are easily measured and noninvasive, allowing the exploration of the underlying neurophysiological mechanisms and characteristics of the cognitive dysfunction of several psychiatric disorders, including pediatric OCD 18 and attention deficit/hyperactivity disorder. 19 The P300 component, which is observed ~300 ms after stimulus onset, is considered an index of information processing in the brain.…”

Section: Introductionmentioning

confidence: 99%

A longitudinal, event-related potential pilot study of adult obsessive-compulsive disorder with 1-year follow-up

Yamamuro

Okada²,

Kishimoto

et al. 2016

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AimEarlier brain imaging research studies have suggested that brain abnormalities in obsessive-compulsive disorder (OCD) normalize as clinical symptoms improve. However, although many studies have investigated event-related potentials (ERPs) in patients with OCD compared with healthy control subjects, it is currently unknown whether ERP changes reflect pharmacological and psychotherapeutic effects. As such, the current study examined the neurocognitive components of OCD to elucidate the pathophysiological abnormalities involved in the disorder, including the frontal-subcortical circuits.MethodsThe Yale-Brown Obsessive-Compulsive Scale was used to evaluate 14 adult patients with OCD. The present study also included ten age-, sex-, and IQ-matched controls. The P300 and mismatch negativity (MMN) components during an auditory oddball task at baseline for both groups and after 1 year of treatment for patients with OCD were measured.ResultsCompared with controls, P300 amplitude was attenuated in the OCD group at Cz and C4 at baseline. Pharmacotherapy and psychotherapy treatment for 1 year reduced OCD symptomology. P300 amplitude after 1 year of treatment was significantly increased, indicating normalization compared with baseline at Fz, Cz, C3, and C4. We found no differences in P300 latency, MMN amplitude, or MMN latency between baseline and after one year of treatment.ConclusionERPs may be a useful tool for evaluating pharmacological and cognitive behavioral therapy in adult patients with OCD.

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Event-related potentials in drug-naïve pediatric patients with obsessive-compulsive disorder

Cited by 14 publications

References 45 publications

Associations between the mismatch-negativity component and symptom severity in children and adolescents with attention deficit/hyperactivity disorder

Associations between the mismatch-negativity component and symptom severity in children and adolescents with attention deficit/hyperactivity disorder

Event-related potentials reflect the efficacy of pharmaceutical treatments in children and adolescents with attention deficit/hyperactivity disorder

A longitudinal, event-related potential pilot study of adult obsessive-compulsive disorder with 1-year follow-up

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