Event-related potential correlates of affective response inhibition in bipolar I disorder: Comparison with schizophrenia

Menkes, Margo W.; Andrews, Carolyn M.; Suzuki, Takakuni; Chun, Jinsoo; O’Donnell, Lisa; Grove, Tyler B.; Deng, Wisteria; McInnis, Melvin G.; Deldin, Patricia; Tso, Ivy F.

doi:10.1016/j.jad.2022.04.118

Cited by 5 publications

(15 citation statements)

References 44 publications

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“…Individuals with BD responded slower on successful Go trials than HC during the affective Go/No-Go task, as expected. As noted in our prior work, individuals with BD showed poorer behavioral discrimination of emotional versus neutral facial expressions (d'), but did not differ from HC on response bias (β) (Menkes et al, 2022). We did not observe relationships between thetaband measures and sensitivity; however, theta activity was significantly correlated with behavioral performance (with both higher power and inter-trial phase consistency corresponding to quicker reaction times on Go trials, and higher power corresponding to a stronger tendency to respond) across participants.…”

Section: Discussionsupporting

confidence: 70%

“…It should be noted that ERP analyses published on this dataset (Menkes et al, 2022) did not find significant differences between HC and BD groups on N200 amplitudes-which is thought to also be an electrophysiological index of cognitive control (Folstein and Van Petten, 2008). The current findings of theta activity reductions in BD and their association with task performance suggest that non-phase-locked theta activity contributes to affective response inhibition deficits in BD.…”

Section: Discussionmentioning

confidence: 44%

“…Prior findings of attenuated N200 amplitudes in BD have provided some evidence for reduced neurophysiological activity during response inhibition (Michelini et al, 2016;Van Voorhis et al, 2019); however, results are mixed. For example, ERP analyses from our research group did not find significant alterations to N200 amplitudes in BD (Menkes et al, 2022). Further, the N200 is proposed to reflect part of the changes in theta-band activity over the medial frontal cortex that are elicited by response conflict, suggesting midline fronto-central theta oscillations underlie the N200 (Cavanagh et al, 2012;Cavanagh and Frank, 2014).…”

Section: Introductionmentioning

confidence: 59%

“…If individuals with BD are particularly impaired in reacting to the need to inhibit, we would expect to see a greater deficit following No-Go cues. However, our prior analyses of event-related potentials (ERPs) in BD did not indicate any No-Go specific impairments (Menkes et al, 2022). This leads to the expectation that individuals with BD would show reductions in theta activity indexing broad cognitive control process across a response inhibition task.…”

Section: Introductionmentioning

confidence: 87%

“…For HC, psychiatric diagnoses were ruled out through a diagnostic interview based on DSM-IV criteria (either the DIGS or the Structured Clinical Interview for DSM-IV-TR; SCID-IV; First et al, 1996). 66 of the BD participants and all HC participants from the present sample were also included in a previous report on ERP analyses during current Go/No-Go task (Menkes et al, 2022). All participants completed informed consent and monetary compensation was provided for participation.…”

Section: Participantsmentioning

confidence: 99%

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Reduced theta-band neural oscillatory activity during affective cognitive control in bipolar I disorder

Menkes¹,

Andrews²,

Suzuki³

et al. 2022

Preprint

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Background: Individuals with bipolar I disorder (BD) have difficulty inhibiting context-inappropriate responses. However, neural mechanisms of impaired cognitive control over impulsive behaviors, especially in response to emotion, are unclear. Theta-band neural oscillatory activity over midfrontal areas is thought to reflect cognitive control. The current study examined behavioral performance and theta-band activity during inhibition to affective stimuli in BD, relative to healthy control participants (HC). Methods: Sixty-seven participants with BD and 48 HC completed a Go/No-Go task with emotional face stimuli during electroencephalography (EEG) recording. Behavior was measured with reaction time and signal detection metrics (perceptual sensitivity, response bias). Time-frequency decomposition of EEG data was used to extract event-related theta-band (3-7 Hz) neural oscillatory power and inter-trial phase consistency over midline fronto-central areas. Behavior and theta-band activity measures were compared between groups, while covarying for age. Results: Participants with BD exhibited slower reaction times when executing correct responses and reduced behavioral discrimination of emotional vs. neutral faces, compared to HC. Theta-band power and inter-trial phase consistency were reduced in BD relative to HC and reduced on Go trials relative to No-Go trials. The magnitude of differences in theta-band activity between Go/No-Go trial types did not differ between groups. Higher theta-band power and inter-trial phase consistency were both associated with quicker reaction times on Go trials, and higher power was associated with a stronger response tendency. Conclusions: Attenuated midline fronto-central theta-band power and inter-trial phase consistency may contribute to reduced cognitive control and maladaptive behavioral responding to emotional cues in individuals with BD.

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Section: Discussionsupporting

confidence: 70%

Section: Discussionmentioning

confidence: 44%

Section: Introductionmentioning

confidence: 59%

Section: Introductionmentioning

confidence: 87%

Section: Participantsmentioning

confidence: 99%

See 3 more Smart Citations

Reduced theta-band neural oscillatory activity during affective cognitive control in bipolar I disorder

Menkes¹,

Andrews²,

Suzuki³

et al. 2022

Preprint

Self Cite

View full text Add to dashboard Cite

show abstract

Reduced theta-band neural oscillatory activity during affective cognitive control in bipolar I disorder

Andrews¹,

Menkes²,

Suzuki³

et al. 2023

Journal of Psychiatric Research

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Changes in neurotransmitter levels, brain structural characteristics, and their correlation with PANSS scores in patients with first-episode schizophrenia

Xu,

Liu,

et al. 2023

World J Clin Cases

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In recent years, because of the growing desire to improve the noninvasiveness and safety of tumor treatments, sonodynamic therapy has gradually become a popular research topic. However, due to the complexity of the therapeutic process, the relevant mechanisms have not yet been fully elucidated. One of the widely accepted possibilities involves the effect of reactive oxygen species. In this review, the mechanism of reactive oxygen species production by sonodynamic therapy (SDT) and ways to enhance the sonodynamic production of reactive oxygen species are reviewed. Then, the clinical application and limitations of SDT are discussed. In conclusion, current research on sonodynamic therapy should focus on the development of sonosensitizers that efficiently produce active oxygen, exhibit biological safety, and promote the clinical transformation of sonodynamic therapy.

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Event-related potential correlates of affective response inhibition in bipolar I disorder: Comparison with schizophrenia

Cited by 5 publications

References 44 publications

Reduced theta-band neural oscillatory activity during affective cognitive control in bipolar I disorder

Reduced theta-band neural oscillatory activity during affective cognitive control in bipolar I disorder

Reduced theta-band neural oscillatory activity during affective cognitive control in bipolar I disorder

Changes in neurotransmitter levels, brain structural characteristics, and their correlation with PANSS scores in patients with first-episode schizophrenia

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