Event-Related Phase-Amplitude Coupling During Working Memory of Musical Chords

Huang, Ting; Ding, Hsien-Ming; Tseng, Yeu-Yang

doi:10.1109/access.2021.3097774

Cited by 3 publications

(1 citation statement)

References 108 publications

(311 reference statements)

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“…Phase-amplitude coupling has been hypothesized to play a crucial role in the temporal parsing of (quasi) rhythmic stimulation ( Hyafil et al, 2015 ). Previous studies suggest an association between theta-gamma PAC and auditory processing, with increased coupling when the processing performs better ( Papadaniil et al, 2015 ; Mai et al, 2016 ; Tseng et al, 2019 ; Huang et al, 2021 ). This is argued that theta oscillations in the cortices reflect the rhythm of simulation, whereas gamma oscillations represent the higher-level processing.…”

Section: Discussionmentioning

confidence: 97%

Individualized music induces theta-gamma phase-amplitude coupling in patients with disorders of consciousness

Xiao,

Zheng,

Wen

et al. 2024

Front. Neurosci.

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ObjectiveThis study aimed to determine whether patients with disorders of consciousness (DoC) could experience neural entrainment to individualized music, which explored the cross-modal influences of music on patients with DoC through phase-amplitude coupling (PAC). Furthermore, the study assessed the efficacy of individualized music or preferred music (PM) versus relaxing music (RM) in impacting patient outcomes, and examined the role of cross-modal influences in determining these outcomes.MethodsThirty-two patients with DoC [17 with vegetative state/unresponsive wakefulness syndrome (VS/UWS) and 15 with minimally conscious state (MCS)], alongside 16 healthy controls (HCs), were recruited for this study. Neural activities in the frontal–parietal network were recorded using scalp electroencephalography (EEG) during baseline (BL), RM and PM. Cerebral-acoustic coherence (CACoh) was explored to investigate participants’ abilitiy to track music, meanwhile, the phase-amplitude coupling (PAC) was utilized to evaluate the cross-modal influences of music. Three months post-intervention, the outcomes of patients with DoC were followed up using the Coma Recovery Scale-Revised (CRS-R).ResultsHCs and patients with MCS showed higher CACoh compared to VS/UWS patients within musical pulse frequency (p = 0.016, p = 0.045; p < 0.001, p = 0.048, for RM and PM, respectively, following Bonferroni correction). Only theta-gamma PAC demonstrated a significant interaction effect between groups and music conditions (F(2,44) = 2.685, p = 0.036). For HCs, the theta-gamma PAC in the frontal–parietal network was stronger in the PM condition compared to the RM (p = 0.016) and BL condition (p < 0.001). For patients with MCS, the theta-gamma PAC was stronger in the PM than in the BL (p = 0.040), while no difference was observed among the three music conditions in patients with VS/UWS. Additionally, we found that MCS patients who showed improved outcomes after 3 months exhibited evident neural responses to preferred music (p = 0.019). Furthermore, the ratio of theta-gamma coupling changes in PM relative to BL could predict clinical outcomes in MCS patients (r = 0.992, p < 0.001).ConclusionIndividualized music may serve as a potential therapeutic method for patients with DoC through cross-modal influences, which rely on enhanced theta-gamma PAC within the consciousness-related network.

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