Event-related neural oscillation changes following reasoning training in individuals with Mild Cognitive Impairment

Mudar, Raksha A.; Nguyen, Lydia T.; Eroh, Justin; Chiang, Hsueh-Sheng; Rackley, Audette; Chapman, Sandra B.

doi:10.1016/j.brainres.2018.10.017

Cited by 10 publications

(14 citation statements)

References 94 publications

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Section: Methodsmentioning

confidence: 99%

“…In previous MCI research, SMART training was labeled as gist reasoning training (Mudar et al, 2017, 2019). Detailed information about the specifics of the training can be found in Mudar et al (2017, 2019). Training was delivered to all participants in both groups in sessions involving small groups of 2–5 individuals over 4 weeks, consisting of two 1-h sessions per week for a total of 8 h of training.…”

Section: Methodsmentioning

confidence: 99%

“…Gist reasoning training has also shown to be beneficial in individuals with MCI (Mudar et al, 2017, 2019). In a separate but recently completed randomized pilot study, MCI individuals who underwent SMART improved in strategic processing and attention during a list learning task and on a concept abstraction measure relative to an active control group that received new learning of relevant facts about brain health (Mudar et al, 2017).…”

Section: Introductionmentioning

confidence: 99%

“…Not only did the SMART trained group show significant improvement on cognitive and self-reported memory measures, but training-related modulations in neural functions were also noted. With regard to neural changes, MCI individuals who underwent SMART training showed enhanced event-related desynchronization in low-frequency alpha band (8–10 Hz) on response inhibition (NoGo) trials and high-frequency alpha band (11–13 Hz) on response execution (Go) trials relative to the active control group (Mudar et al, 2019).…”

Section: Introductionmentioning

confidence: 99%

“…Finally, we wanted to explore whether SMART training improved cognitive functions irrespective of the a-tDCS or s-tDCS group. Based on prior results showing adults with MCI benefitted from SMART protocol (Mudar et al, 2017, 2019), we proposed that both groups would show cognitive gains.…”

Section: Introductionmentioning

confidence: 99%

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Cognitive Training and Transcranial Direct Current Stimulation in Mild Cognitive Impairment: A Randomized Pilot Trial

et al. 2019

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Background Transcranial direct current stimulation (tDCS), a non-invasive stimulation, represents a potential intervention to enhance cognition across clinical populations including Alzheimer’s disease and mild cognitive impairment (MCI). This randomized clinical trial in MCI investigated the effects of anodal tDCS (a-tDCS) delivered to left inferior frontal gyrus (IFG) combined with gist-reasoning training (SMART) versus sham tDCS (s-tDCS) plus SMART on measures of cognitive and neural changes in resting cerebral blood flow (rCBF). We were also interested in SMART effects on cognitive performance regardless of the tDCS group. Methods Twenty-two MCI participants, who completed the baseline cognitive assessment (T1), were randomized into one of two groups: a-tDCS + SMART and s-tDCS + SMART. Of which, 20 participants completed resting pCASL MRI scan to measure rCBF. Eight SMART sessions were administered over 4 weeks with a-tDCS or s-tDCS stimulation for 20 min before each session. Participants were assessed immediately (T2) and 3-months after training (T3). Results Significant group × time interactions showed cognitive gains at T2 in executive function (EF) measure of inhibition [DKEFS- Color word ( p = 0.047)], innovation [TOSL ( p = 0.01)] and on episodic memory [TOSL ( p = 0.048)] in s-tDCS + SMART but not in a-tDCS + SMART group. Nonetheless, the gains did not persist for 3 months (T3) after the training. A voxel-based analysis showed significant increase in regional rCBF in the right middle frontal cortex (MFC) (cluster-wise p = 0.05, k = 1,168 mm 3 ) in a-tDCS + SMART compared to s-tDCS + SMART. No significant relationship was observed between the increased CBF with cognition. Irrespective of group, the combined MCI showed gains at T2 in EF of conceptual reasoning [DKEFS card sort ( p = 0.033)] and category fluency [COWAT ( p = 0.055)], along with gains at T3 in EF of verbal fluency [COWAT ( p = 0.009)]. Conclusion One intriguing finding is a-tDCS to left IFG plus SMART increased blood flow to right MFC, however, the stimulation seemingly blocked cognitive benefits of SMART on EF (inhibition and innovation) and episodic memory compared to s-tDCS + SMART group. Although the sample size is small, this paper contributes to growing evidence that cognitive training provides a way to significantly enhance cognitive performance in adults showing memory loss, where the role of a-tDCS in augmenting these effects need further study.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Cognitive Training and Transcranial Direct Current Stimulation in Mild Cognitive Impairment: A Randomized Pilot Trial

et al. 2019

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Can discourse processing performance serve as an early marker of Alzheimer’s disease and mild cognitive impairment? A systematic review of text comprehension

et al. 2021

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A number of linguistic and cognitive deficits have been reported during the course of Alzheimer’s disease (AD) and its preceding stage of mild cognitive impairment (MCI), with some deficits appearing years before onset of clinical symptoms. It continues to be a critical task to identify tools that may serve as an early marker of pathology that are also reliably able to distinguish AD from normal ageing. Given the limited success of classic psychometric cognitive testing, a novel approach in assessment is warranted. A potentially sensitive assessment paradigm is discourse processing. The aim of this review was to synthesize original research studies investigating comprehension of discourse in AD and MCI, and to evaluate the potential of this paradigm as a promising avenue for further research. A literature search targeting studies with AD or MCI groups over 60 years of age was conducted in PubMed, Web of Science, and PsycINFO databases. Eight articles with good quality were included in the review. Six measures of discourse comprehension—naming latency, summary, lesson, main idea, proportion of inferential clauses, true/false questions—were identified. All eight studies reported significant deficits in discourse comprehension in AD and MCI groups on five of the six measures, when compared to cognitively healthy older adults. Mixed results were observed for associations with commonly used cognitive measures. Given the consistent findings for discourse comprehension measures across all studies, we strongly recommend further research on its early predictive potential, and discuss different avenues for research.

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Effects of transcranial electrical stimulation on episodic memory in physiological and pathological ageing

Sandrini

Manenti

Sahin

et al. 2020

Ageing Research Reviews

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Event-related neural oscillation changes following reasoning training in individuals with Mild Cognitive Impairment

Cited by 10 publications

References 94 publications

Cognitive Training and Transcranial Direct Current Stimulation in Mild Cognitive Impairment: A Randomized Pilot Trial

Cognitive Training and Transcranial Direct Current Stimulation in Mild Cognitive Impairment: A Randomized Pilot Trial

Can discourse processing performance serve as an early marker of Alzheimer’s disease and mild cognitive impairment? A systematic review of text comprehension

Effects of transcranial electrical stimulation on episodic memory in physiological and pathological ageing

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