Event-Related fMRI with Simultaneous and Continuous EEG: Description of the Method and Initial Case Report

Lemieux, Louis; Salek‐Haddadi, Afraim; Josephs, Oliver; Allen, Philip J.; Toms, N.; Scott, Catherine; Krakow, Karsten; Turner, Robert; Fish, D. R.

doi:10.1006/nimg.2001.0853

Cited by 259 publications

(153 citation statements)

References 19 publications

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“…All fMRI data were pre-processed and analyzed using SPM2 Using MR-compatible equipment, ten EEG channels (gold disk electrodes with 10 kOhm safety resistors) were recorded at electrode positions Fp2/Fp1, F8/F7, T4/T3, T6/T7, O2/O1, Fz (ground) and Pz as the reference (10-20 system), and bipolar ECG. In-house EEG recording equipment with a 5kHz sampling rate, 33.3 mV range at 2µV resolution was used, with online pulse and imaging artefact subtraction [13,14,15,16,17]. Further offline imaging and pulse artifact removal was performed using the Brain Vision Analyzer [18].…”

Section: Methodsmentioning

confidence: 99%

EEG–fMRI mapping of asymmetrical delta activity in a patient with refractory epilepsy is concordant with the epileptogenic region determined by intracranial EEG

Laufs

Hamandi

Walker

et al. 2006

Magnetic Resonance Imaging

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Using continuous EEG-correlated fMRI, we studied a patient with refractory epilepsy. Seizures were characterised by head turning to the left and clonic jerking of the left arm suggesting a right mesial frontal onset. Routine interictal EEG showed symmetrical post-central alpha rhythm and occasional runs of independent, non-lateralized slow activity in the delta band with right frontocentral dominance. Ictal scalp EEG had no lateralizing value. Structural MRI showed no abnormality. There were no clear EEG changes during simultaneous EEG-fMRI. We therefore

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Section: Methodsmentioning

confidence: 99%

EEG–fMRI mapping of asymmetrical delta activity in a patient with refractory epilepsy is concordant with the epileptogenic region determined by intracranial EEG

Laufs

Hamandi

Walker

et al. 2006

Magnetic Resonance Imaging

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“…As in prior studies (Meeren et al, 2002), we found that field potentials were present during SWD in the barrel cortex but not in the primary visual cortex, whereas during tonic-clonic seizures, field potential activity was present in both locations (data not shown). We should note that our aim in this study was not to investigate quantitative aspects of neurovascular coupling; rather, our purpose was to determine whether CBF increases or decreases in brain regions involved and spared electrophysiologically during different types of seizures, justifying the use of neuroimaging approaches to study local changes in epilepsy (Lemieux et al, 2001;Richardson, 2002;Zubal et al, 1995).…”

Section: Figmentioning

confidence: 99%

“…Are increases spatially confined to the regions of seizure activity, or do they also occur in regions spared by seizures? These questions have important clinical applications, because functional neuroimaging is increasingly used to localize epileptic seizures and guide focal surgical treatment (Lemieux et al, 2001;O'Brien et al, 1998;Richardson, 2002;Rosenow and Luders, 2001;Zubal et al, 1995).…”

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confidence: 99%

Relative Changes in Cerebral Blood Flow and Neuronal Activity in Local Microdomains during Generalized Seizures

Nersesyan

Hermán

Erdogan³

et al. 2004

J Cereb Blood Flow Metab

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Summary:There is broad agreement that generalized tonicclonic seizures (GTCS) and normal somatosensory stimulation are associated with increases in regional CBF. However, the data regarding CBF changes during absence seizures are controversial. Electrophysiologic studies in WAG/Rij rats, an established animal model of absence seizures, have shown spikewave discharges (SWD) that are largest in the perioral somatosensory cortex while sparing the visual cortex. Recent functional magnetic resonance imaging (fMRI) studies in the same model have also shown localized increases in fMRI signals in the perioral somatosensory cortex during SWD. Because fMRI signals are only indirectly related to neuronal activity, the authors directly measured CBF and neuronal activity from specific microdomains of the WAG/Rij cortex using a specially designed probe combining laser-Doppler flowmetry and extracellular microelectrode recordings under fentanyl/haloperidol anesthesia. Using this approach, parallel increases in neuronal activity and CBF were observed during SWD in the whisker somatosensory (barrel) cortex, whereas the visual cortex showed no significant changes. For comparison, these measurements were repeated during somatosensory (whisker) stimulation, and bicuculline-induced GTCS in the same animals. Interestingly, whisker stimulation increased neuronal activity and CBF in the barrel cortex more than during SWD. During GTCS, much larger increases that included both the somatosensory and visual cortex were observed. Thus, SWD in this model produce parallel localized increases in neuronal activity and CBF with similar distribution to somatosensory stimulation, whereas GTCS produce larger and more widespread changes. The normal response to somatosensory stimulation appears to be poised between two abnormal responses produced by two physiologically different types of seizures.

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“…While the initial efforts in this multimodal enterprise were aimed at solving technical problems stemming mainly from artifacts in the EEG generated in the MR environment (Allen et al, 2000;Allen et al, 1998;Bonmassar et al, 1999;Bonmassar et al, 2002), subsequent research has explored the relationship between EEG and BOLD from various vantage points. For instance, quite some effort has been devoted to identify BOLD correlates of epileptoform EEG activity (Aghakhani et al, 2004;Al-Asmi et al, 2003;Benar et al, 2006;Lemieux et al, 2001;Salek-Haddadi et al, 2002). More recently, simultaneous EEG/ fMRI has been successfully applied to investigate cognitive phenomena such as performance monitoring (Debener et al, 2005) and sustained attention (Eichele et al, 2005).…”

Section: Introductionmentioning

confidence: 99%

Frontal theta EEG activity correlates negatively with the default mode network in resting state

Scheeringa¹,

Bastiaansen²,

Petersson³

et al. 2008

International Journal of Psychophysiology

365

295

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We used simultaneously recorded EEG and fMRI to investigate in which areas the BOLD signal correlates with frontal theta power changes, while subjects were quietly lying resting in the scanner with their eyes open. To obtain a reliable estimate of frontal theta power we applied ICA on band-pass filtered (2-9 Hz) EEG data. For each subject we selected the component that best matched the mid-frontal scalp topography associated with the frontal theta rhythm. We applied a time-frequency analysis on this component and used the time course of the frequency bin with the highest overall power to form a regressor that modeled spontaneous fluctuations in frontal theta power. No significant positive BOLD correlations with this regressor were observed. Extensive negative correlations were observed in the areas that together form the default mode network. We conclude that frontal theta activity can be seen as an EEG index of default mode network activity.

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Event-Related fMRI with Simultaneous and Continuous EEG: Description of the Method and Initial Case Report

Cited by 259 publications

References 19 publications

EEG–fMRI mapping of asymmetrical delta activity in a patient with refractory epilepsy is concordant with the epileptogenic region determined by intracranial EEG

EEG–fMRI mapping of asymmetrical delta activity in a patient with refractory epilepsy is concordant with the epileptogenic region determined by intracranial EEG

Relative Changes in Cerebral Blood Flow and Neuronal Activity in Local Microdomains during Generalized Seizures

Frontal theta EEG activity correlates negatively with the default mode network in resting state

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