This paper uses computational complexity theory to assess the difficulty of various discrete event simulation problems. More specifically, accessibility of states, ordering of events, noninterchangeability of model implementations, and execution stalling for discrete event simulations are formally stated as search problems and proven to be NP-hard. The consequences of these results cover a wide range of modeling and analysis problems in simulation. For example, problems associated with certain variance reduction techniques, model verification, model validation, and the applicability of infinitesimal perturbation analysis, among others, are deemed intractable.