Eveningness intensifies the association between musculoskeletal pain and health-related quality of life: a Northern Finland Birth Cohort Study 1966

Heikkala, Eveliina; Paananen, Markus; Merikanto, Ilona; Karppinen, Jaro; Oura, Petteri

doi:10.1097/j.pain.0000000000002609

Cited by 9 publications

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“…These eight pain locations were merged, and those who responded ‘no’ in regard to each pain location were excluded. The overall frequency of pain was defined as the highest reported frequency of all pain locations, divided into four categories: (1) on 1 to 7 days (the reference), (2) on 8 to 30 days, (3) on more than 30 days but not daily and (4) daily (Heikkala, Paananen, et al, 2022).…”

Section: Methodsmentioning

confidence: 99%

“…When participants reported any MSK pain, they were asked to estimate the overall bothersomeness of pain and overall pain intensity on a numerical rating scale (NRS) ranging from 0 to 10, in which 0 equaled ‘no pain’ and 10 equaled ‘total disability/extremely intense pain’ (Heikkala, Paananen, et al, 2022). The question on bothersomeness of pain included three subscales on a 0–10 NRS scale: (a) at work, (b) during leisure time and (c) while sleeping.…”

Section: Methodsmentioning

confidence: 99%

“…A recent analysis of World Health Organization data revealed MSK pain as the second most common reason for disability and disability pensions globally (Sebbag et al, 2019). MSK pain that leads to adverse outcomes is usually persistent, intense and bothersome, and exists in several anatomical sites in the MSK system (Artus et al, 2017; Heikkala, Paananen, et al, 2022; Kooijman et al, 2015; Valentin et al, 2016; Whibley et al, 2015), highlighting the need to search for determinants of these pain dimensions. In the general population, between 11% and 24% of people have been estimated to experience persistent and/or disabling MSK pain (Arnow et al, 2006; Fayaz et al, 2016; Meucci et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

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Accumulation of long‐term diseases is associated with musculoskeletal pain dimensions among middle‐aged individuals with musculoskeletal pain

Heikkala

Oura

et al. 2023

European Journal of Pain

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Background: Long-term diseases often co-occur with musculoskeletal (MSK) pain. In middle-aged individuals with MSK pain, it remains unclear whether an accumulation (two or more) of long-term diseases is associated with MSK pain dimensions, including pain frequency, bothersomeness of pain, pain intensity and number of pain sites. Methods:This cross-sectional study included data from the Northern Finland Birth Cohort 1966 collected in 2012-2014 when the participants were 46 years of age. We included participants who reported having MSK pain during the previous year (collected retrospectively) and provided self-reported information related to MSK pain dimensions, long-term diseases and potential confounders (n = 4469).The association between long-term diseases and pain dimensions was modelled by general linear and logistic regression models, with beta (β) coefficients, odds ratios (ORs) and their 95% confidence intervals (CIs) being presented. Unadjusted models were followed by models adjusted for sex, educational level and smoking. Results:The presence of accumulated long-term diseases was associated with over two-fold higher odds of daily pain (adjusted OR 2.6, 95% CI 2.0-3.4) and significantly higher levels of bothersomeness of pain and pain intensity (adjusted β 1.1, 95% CI 0.9-1.4; adjusted β 1.0, 95% CI 0.8-1.1, respectively), relative to the absence of long-term diseases. Females with accumulated long-term diseases had a stronger relationship to number of pain sites than males. Associations between one long-term disease and pain dimensions were significant but smaller in magnitude. Conclusion:There is a need for a better understanding of the relationships between accumulated long-term diseases and MSK pain.Significance: This study on middle-aged individuals with musculoskeletal pain showed that the presence of long-term diseases was clearly associated with pain frequency, bothersomeness of pain, pain intensity and number of pain sites.Compared with no long-term diseases, the association between accumulated (two or more) long-term diseases and pain dimensions was stronger than the association between one long-term disease and pain dimensions.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Accumulation of long‐term diseases is associated with musculoskeletal pain dimensions among middle‐aged individuals with musculoskeletal pain

Heikkala

Oura

et al. 2023

European Journal of Pain

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“…Other factors may also explain the relation between sleep disturbances and pain. Different patients with chronic pain may have different circadian pain rhythms (91) and chronotypes (92). Some may have the highest pain intensity at wake-up that decreases during the day, while others may experience similarly high pain intensity in the morning that gradually decreases until it increases again from afternoon to night.…”

Section: Insomniamentioning

confidence: 99%

“…Interestingly, people with chronotype E (i.e., most active in the evening) experience a higher degree of musculoskeletal pain compared to those with chronotype M (i.e., most active in the morning). Collectively, circadian pain rhythms and chronotypes may have influence on pain (92).…”

Section: Insomniamentioning

confidence: 99%

Are Morphometric and Biomechanical Characteristics of Lumbar Multifidus Related to Pain Intensity or Disability in People With Chronic Low Back Pain After Considering Psychological Factors or Insomnia?

et al. 2022

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IntroductionLumbar multifidus muscle (LMM) dysfunction is thought to be related to pain and/or disability in people with chronic low back pain (CLBP). Although psychosocial factors play a major role in pain/disability, they are seldom considered as confounders in analyzing the association between LMM and CLBP.ObjectivesThis study aimed to determine: (1) differences in psychological factors, insomnia, and LMM characteristics between people with and without CLBP; (2) associations between psychological factors, insomnia, or LMM characteristics and low back pain (LBP) intensity or LBP-related disability in people with CLBP; and (3) whether LMM characteristics are related to LBP symptoms in people with CLBP after considering confounders.MethodsSeventy-eight volunteers with CLBP and 73 without CLBP provided sociodemographic information, filled the 11-point numeric pain rating scale and Roland-Morris disability questionnaire (RMDQ). They completed the Hospital Anxiety and Depression Scale (HADS), Pain Catastrophizing Scale (PCS), Fear Avoidance Belief Questionnaire (FAB), and Insomnia Severity Index Scale (ISI). Resting and contracted thickness of LMM at L4-S1 levels were measured from brightness-mode ultrasound images. Percent thickness changes of LMM at L4-S1 levels during contraction were calculated. Resting LMM stiffness at L4-S1 was measured by shear wave elastography. Associations among LMM, psychosocial or insomnia parameters and clinical outcomes were analyzed by univariate and multivariate analyses.ResultsPeople with CLBP demonstrated significantly higher LBP-intensity, RMDQ, HADS, FAB, PCS, and ISI scores than asymptomatic controls (p < 0.05). The former also had significantly smaller percent thickness changes of LMM at L4/L5 during contraction. LBP-intensity was positively related to scores of PCS-total, PCS-helplessness, FAB-total, FAB-work, and ISI in people with CLBP (p < 0.05). RMDQ scores were positively associated with the scores of HADS-total, HADS-depression, PCS-total, FAB-total, FAB-physical activity, PCS-helplessness, and ISI in people with CLBP (p < 0.05). FAB-work and ISI scores together explained 24% of LBP-intensity. FAB-total scores alone explained 34% of variance of LBP-related disability in people with CLBP.ConclusionMore fear-avoidance belief or insomnia is related to greater LBP-intensity and/or LBP-related disability in people with CLBP. Although people with CLBP were thought to have aberrant LMM morphometry/function, no LMM characteristics were related to LBP-intensity or LBP-related disability after considering other confounders.

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Chronobiological variables predict non-response to serotonin and noradrenaline reuptake inhibitors in fibromyalgia: a cross-sectional study

Krupa,

Chrobak,

Sołtys

et al. 2024

Rheumatol Int

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Available data shows associations between chronotype, circadian rhythms, sleep quality and fibromyalgia (FM) presentation. However, no studies have explored links between the chronobiological variables and effectiveness of pharmacotherapy. We aimed to assess the chronotypes, circadian rhythms, sleep-wake cycle and sleep quality in FM and their links to treatment response to serotonin and noradrenalin reuptake inhibitors (SNRI). 60 FM patients: 30 responsive to SNRI (FM T[+]), 30 non-responsive to SNRI (FM T[-]) and 30 healthy controls participated. Subjects were assessed by physician and with questionnaire tools: Composite Scale of Morningness, Biological Rhythms Interview of Assessment in Neuropsychiatry, Sleep-Wake Pattern Assessment Questionnaire, Pittsburgh Sleep Quality Index and Fibromyalgia Impact Questionnaire. ANOVA analysis and simple logistic regressions were used to examine the relationships between chronological variables and response to SNRI. FM T[-] vs. FM T[+] presented lower morning affect (11.50[95%CI 9.96-13.04] vs. 14.00[95%CI 12.42-15.57];p=0.04), anytime wakeability (2.27[95%CI 1.4-3.13] vs. 4.03[95%CI 2.99-5.08];p=0.013) worse overall (11.40[95%CI 9.92-12.88] vs. 7.97[95%CI 6.75-9.19];p=0.002) and subjective (1.70[95%CI 1.30-2.01] vs. 1.17[95%CI 0.94-1.39];p=0.008) sleep quality, higher circadian rhythm disruptions (55.47[95%CI 52.32-58.62] vs. 44.97[95%CI 41.31-48.62];p<0.001), sleep disturbances (1.63[95%CI 1.38-1.68] vs. 1.30[95%CI 1.1-1.5];p=0.04), sleeping-medication use (1.80[95%CI 1.27-2.32] vs. 0.70[95%CI 0.28-1.12];p=0.003). Levels of morningness (AIC=82.91,OR=0.93,p=0.05), morning affect (AIC=81.901,OR=0.86,p=0.03) diurnal dysrhythmia (AIC=69.566,OR=1.14,p<0.001), anytime wakeability (AIC=80.307,OR=0.76,p=0.015), overall sleep quality (AIC=74.665, OR=1.31,p=0.002) subjective sleep quality (AIC=79.353, OR=2.832,p=0.01) and disturbances (AIC=82.669,OR=2.54,p=0.043), sleep medication use (AIC=77.017, OR=1.9,p=0.003) and daytime disfunction (AIC=82.908, OR=1.971,p=0.049) were predictors of non-response to SNRI. Chronobiological variables vary between FM T[+] and FM T[-] and are predictors of non-response to SNRI.

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Eveningness intensifies the association between musculoskeletal pain and health-related quality of life: a Northern Finland Birth Cohort Study 1966

Abstract: The associations between 4 pain dimensions and health-related quality of life were stronger among evening than morning chronotypes with musculoskeletal pain.Supplemental Digital Content is Available in the Text.

Cited by 9 publications

References 50 publications

Accumulation of long‐term diseases is associated with musculoskeletal pain dimensions among middle‐aged individuals with musculoskeletal pain

Accumulation of long‐term diseases is associated with musculoskeletal pain dimensions among middle‐aged individuals with musculoskeletal pain

Are Morphometric and Biomechanical Characteristics of Lumbar Multifidus Related to Pain Intensity or Disability in People With Chronic Low Back Pain After Considering Psychological Factors or Insomnia?

Chronobiological variables predict non-response to serotonin and noradrenaline reuptake inhibitors in fibromyalgia: a cross-sectional study

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