Evening primrose oil for cervical ripening prior to labor induction in post-term pregnancies: A randomized controlled trial

Azad, Afrooz; Pourtaheri, Mohaddeseh; Darsareh, Fatemeh; Heidari, Solmaz; Mehrnoush, Vahid

doi:10.1016/j.eujim.2022.102123

Cited by 7 publications

(25 citation statements)

References 21 publications

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“…Six studies were randomized controlled trials (RCTs) and one was quasi-experimental study with a control group. Four studies were conducted in Iran [ 10 , 19 , 27 , 28 ], and three were carried out in Egypt, the United States, and the Philippines [ 15 , 17 , 25 ]. The studies included a total of 920 participants.…”

Section: Resultsmentioning

confidence: 99%

“…The sample size of the mentioned studies ranged from 71 to 240. As far as cervical preparation was concerned, five studies have investigated the Bishop score and birth outcomes [ 15 , 19 , 27 , 28 ], and one measured only the time span between the administration of EPO and onset of childbirth [ 10 ].…”

Section: Resultsmentioning

confidence: 99%

“…EPO was used in form of vaginal suppository in three trials [ 10 , 19 , 28 ]. In one study, a daily dose of 1000 mg vaginal suppository of EPO from the 38th week of pregnancy until birth was used [ 28 ].…”

Section: Resultsmentioning

confidence: 99%

“…EPO is recommended in some midwifery literatures as a cure for post-dates pregnancy, and more than 60% of US nurse-midwives prescribe it in late pregnancy [ 17 , 18 ]. It is also the most common herbal remedy for cervical ripening used by certified midwives in Iran [ 19 ].…”

Section: Introductionmentioning

confidence: 99%

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The effect of evening primrose oil on cervical ripening and birth outcomes: A systematic review and meta-analysis

Sholeh¹,

Abedi²,

Jahanfar³

et al. 2023

Heliyon

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

The effect of evening primrose oil on cervical ripening and birth outcomes: A systematic review and meta-analysis

Sholeh¹,

Abedi²,

Jahanfar³

et al. 2023

Heliyon

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“…One dosage of 1,000 mg of EPO, administered vaginally at 41 weeks of pregnancy, increased the Bishop score and decreased the amount of time needed to deliver a baby in post-term pregnancies in Azad's randomized controlled study (21). It is consistent with our findings, which showed that the average time between dilation to six cm and full dilatation and the time between full dilatation and delivery was not significantly different in the misoprostol and evening primrose groups, despite the significant difference in duration between the first dose of misoprostol and the beginning of active labor.…”

Section: Discussionmentioning

confidence: 99%

Effects of Misoprostol and Evening Primrose Extracts on Cervix Preparation for Labor Induction in Term Pregnancies

Moghimipour

Zargarzadeh

Ghaemi

et al. 2022

Fertil Gynecol Androl

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Background: Ripening is the process of preparing the cervix for induction of labor and is crucial to identify a low-complication, low-cost, and safe method of inducing labor before spontaneous labor begins. Therefore, this study aimed to demonstrate the impact of the evening primrose capsule on inducing labor, as well as to compare its effect to that of misoprostol. Methods: This prospective clinical trial study was performed on 200 low-risk pregnant women candidate for delivery in an academic hospital in Tehran from 2018 to 2020. Patients were randomly divided into two groups to receive 25 µg misoprostol vaginally or 500 mg evening primrose vaginal capsule to induce labor and repeated every three hours until reaching the bishop score > 4 in case of no effective up to three doses. The total drug dose, as well as maternal and neonatal outcomes evaluated and compared between groups. Results: Although misoprostol was significantly more effective than evening primrose in increasing cervical bishop score in the inactive phase of labor, the active phase and delivery time were not different between the groups. Also, there was no significant difference between the two groups in the cesarean section rate. Maternal complications, including uterine hyperstimulation, headache, or gastrointestinal complications in the group receiving misoprostol were significantly higher in misoprostol group, but fetal complications, including Apgar score, pH, hospitalization, and meconium excretion, were not significantly different between the two groups. Conclusions: Evening primrose capsules are safe and can be used to induce labor because of the lower risk of hyperstimulation of the uterus and the higher tolerance. There should be more research done to see if this medicine can be used alone or in conjunction with misoprostol or mechanical dilators or if it can be administered at home rather than in the hospital.

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The effect of sweet almond oil vaginal suppository on the cervical ripening in nulliparous pregnant women: A randomized controlled trial

Hosseini Balajourshari,

Karimi,

Salari

et al. 2024

Advances in Integrative Medicine

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Evening primrose oil for cervical ripening prior to labor induction in post-term pregnancies: A randomized controlled trial

Cited by 7 publications

References 21 publications

The effect of evening primrose oil on cervical ripening and birth outcomes: A systematic review and meta-analysis

The effect of evening primrose oil on cervical ripening and birth outcomes: A systematic review and meta-analysis

Effects of Misoprostol and Evening Primrose Extracts on Cervix Preparation for Labor Induction in Term Pregnancies

The effect of sweet almond oil vaginal suppository on the cervical ripening in nulliparous pregnant women: A randomized controlled trial

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