Even in the era of congenital hypothyroidism screening mild and subclinical sensorineural hearing loss remains a relatively common complication of severe congenital hypothyroidism

Bruno, Rocco; Aversa, Tommaso; Catena, Mariaausilia; Valenzise, Mariella; Lombardo, Fortunato; Luca, Filippo De; Wasniewska, Malgorzata

doi:10.1016/j.heares.2015.04.018

Cited by 35 publications

(35 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…According to these methods, our laboratory reference ranges for TSH and fT4 during the overall study period have remained, respectively, 0.3-5.0 mU/l and 10.3-24.4 pmol/l, as also reported elsewhere [13,14,15,16,17]. …”

Section: Methodssupporting

confidence: 75%

Early Discrimination between Transient and Permanent Congenital Hypothyroidism in Children with Eutopic Gland

et al. 2015

Self Cite

View full text Add to dashboard Cite

Aim: To analyze the factors that might allow an early discrimination between permanent (P) and transient (T) congenital hypothyroidism (CH). Methods: Clinical, biochemical and imaging data of 64 children with eutopic gland, who were positively screened and treated for CH during the period 1998-2011, were retrospectively analyzed. Results: During a 3-year treatment period, the mean doses of L-thyroxine (L-T4) per kilogram of body weight at various times were significantly lower in the 46 children with T CH than in the remaining 18 with P CH. No patients with T CH had required any increment of the doses of L-T4 per kilogram of body weight to maintain normal thyroid-stimulating hormone levels over time, whereas 16/18 children with P CH during the same period had needed some dose increments (p < 0.0001). Conclusions: (a) L-T4 requirements >4.9 µg/kg/day at 12 months or >4.27 µg/kg/day at 24 months are highly suggestive of P CH, irrespective of gland ultrasonography; (b) L-T4 requirements <1.7 µg/kg/day at 12 months or <1.45 µg/kg/day at 24 months are highly suggestive of T CH, at least in the cases with eutopic gland, and (c) the analysis of L-T4 requirements during the first years of treatment might allow an early discrimination between T and P CH in the cases with eutopic gland.

show abstract

Section: Methodssupporting

confidence: 75%

Early Discrimination between Transient and Permanent Congenital Hypothyroidism in Children with Eutopic Gland

et al. 2015

Self Cite

View full text Add to dashboard Cite

show abstract

“…11 In 1 cohort of patients with congenital hypothyroid detected by neonatal screening at 8 to 22 years of age, there was mild and subclinical hearing impairment in approximately 25% of patients, despite early and adequate replacement treatment. 12 The critical period for development of the cochlea starts at the end of the first trimester of pregnancy and continues to the first year of postnatal life. 13 Thyroid hormone has been shown to regulate cochlear development.…”

Section: Figurementioning

confidence: 99%

Maternal Iodine Exposure: A Case of Fetal Goiter and Neonatal Hearing Loss

et al. 2016

View full text Add to dashboard Cite

A 27-year-old gravid 1 at 27 weeks 6 days with a history of hypothyroidism had an ultrasound that demonstrated a 3.9 × 3.2 × 3.3-cm well-circumscribed anterior neck mass, an extended fetal head, and polyhydramnios. Further characterization by magnetic resonance imaging (MRI) showed a fetal goiter. During her evaluation for the underlying cause of the fetal goiter, the patient revealed she was taking nutritional iodine supplements for treatment of her hypothyroidism. She was ingesting 62.5 times the recommended amount of daily iodine in pregnancy. The excessive iodine consumption caused suppression of the fetal thyroid hormone production, resulting in hypothyroidism and goiter formation. After the iodine supplement was discontinued, the fetal goiter decreased in size. At delivery, the airway was not compromised. The infant was found to have reversible hypothyroidism and bilateral hearing loss postnatally. This case illustrates the importance of examining for iatrogenic causes for fetal anomalies, especially in unregulated nutritional supplements.

show abstract

“…However, in that case, the patient was not treated with intra-amniotic levothyroxine injections. That infant was later diagnosed with bilateral hearing loss, which is a known complication of fetal hypothyroidism [41-43]. Hearing screening in our case revealed a normal response bilaterally.…”

Section: Discussionmentioning

confidence: 66%

Iodine-Induced Fetal Hypothyroidism: Diagnosis and Treatment with Intra-Amniotic Levothyroxine

et al. 2018

View full text Add to dashboard Cite

Background: Iodine is necessary for fetal thyroid development. Excess maternal intake of iodine can cause fetal hypothyroidism due to the inability to escape from the Wolff-Chaikoff effect in utero. Case Report: We report a case of fetal hypothyroid goiter secondary to inadvertent excess maternal iodine ingestion from infertility supplements. The fetus was successfully treated with intra-amniotic levothyroxine injections. Serial fetal blood sampling confirmed fetal escape from the Wolff-Chaikoff effect in the mid third trimester. Early hearing test and neurodevelopmental milestones were normal. Conclusion: Intra-amniotic treatment of fetal hypothyroidism may decrease the rate of impaired neurodevelopment and sensorineural hearing loss.

show abstract

Even in the era of congenital hypothyroidism screening mild and subclinical sensorineural hearing loss remains a relatively common complication of severe congenital hypothyroidism

Cited by 35 publications

References 21 publications

Early Discrimination between Transient and Permanent Congenital Hypothyroidism in Children with Eutopic Gland

Early Discrimination between Transient and Permanent Congenital Hypothyroidism in Children with Eutopic Gland

Maternal Iodine Exposure: A Case of Fetal Goiter and Neonatal Hearing Loss

Iodine-Induced Fetal Hypothyroidism: Diagnosis and Treatment with Intra-Amniotic Levothyroxine

Contact Info

Product

Resources

About