Evaporation of decamethylcyclopentasiloxane (D5) from selected cosmetic products: Implications for consumer exposure modeling

Dudzina, Tatsiana; Hidalgo, Elena Garcia; Goetz, Natalie von; Bogdal, Christian; Hungerbuehler, Konrad

doi:10.1016/j.envint.2015.07.013

Cited by 8 publications

(9 citation statements)

References 33 publications

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“…The percentage of applied dose penetrating the skin to reach systemic compartments was <0.1%. These finding were confirmed by the concentration measured in the receptor fluid in the Dudzina et al () in vitro porcine skin experiment.…”

Section: Introductionsupporting

confidence: 66%

“…The fate of D5 following application of LO skin formulations is described using the conceptual model presented in Dudzina et al (), which was preferred versus the Montemayor data, because it incorporated time points that occurred shortly after application of the products. In the Dudzina et al () study, the authors performed an evaporation experiment using neat D5 and commercial formulations on full‐thickness porcine skin tissue placed in a chamber subject to a typical indoor ventilation rate of 4 times/h. The duration of the experiment was limited to 1¼ h; however, measured data show that most of the chemical is lost from the system within this time frame.…”

Section: Methodsmentioning

confidence: 99%

“…The volatility and hydrophobicity of D5 are key parameters that control D5 behavior after consumer application (Montemayor et al ; Dudzina et al ) and after release into the environment (Brooke et al ; McLachlan et al ; Mackay et al ; Kim et al ). Table gives an overview of physicochemical and environmental fate properties.…”

Section: Introductionmentioning

confidence: 99%

“…Volatilization kinetics have been studied in several experiments (Koini et al ; Reddy et al ; Wang et al ; Dudzina et al ), although most of them were designed to inform human exposure. Despite differences in reported rates, all studies demonstrated that evaporation from the applied thin layer on the skin surface is very fast and follows zero‐order kinetics (Koini et al ; Reddy et al ; Dudzina et al ). At typical surface‐specific application rates, this corresponds to a few minutes.…”

Section: Introductionmentioning

confidence: 99%

“…After complete evaporation of the applied film, volatilization continues at a lower rate because the material that had penetrated the skin in the first phase revolatilizes from the skin. The biphasic kinetic process is best described in the compartment model developed by Dudzina et al () to fit experimental data generated from an in vitro porcine skin chamber experiment. The experiment was conducted under controlled air exchange and temperature, representing a realistic scenario of PCP applied to human skin.…”

Section: Introductionmentioning

confidence: 99%

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Estimation of the Contribution Made to Down‐the‐Drain Emissions of D5 by Personal Care Product Categories in the European Union

Franco¹,

Egmond

2019

Integr Envir Assess & Manag

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Aquatic risk assessment of personal care chemicals requires quantifying the contribution of all product types containing these ingredients to down‐the‐drain emissions. We developed a probabilistic model framework embracing stochastic variability associated with individual consumers and their behaviors in the European Union, as well as other sources of uncertainty related to losses following applications (e.g., volatilization). The model was applied to decamethylcyclopentasoloxane (D5), an emollient used in wash‐off (WO) and leave‐on (LO) products. Quantifying contributions from each product category containing D5 to down‐the‐drain emissions is necessary to inform optimal risk management options. Simulation results for the baseline scenario in 2012 support the argument that LO products make up a minor contribution (7.1%) to down‐the‐drain emissions of D5, with only 0.20% of the D5 used in LO products being released to wastewater. The most influential model parameters are the release factor from WO products and the time between application and use for various LO product types, stressing the importance of embracing stochastic variability across individuals’ behavior when assessing contributions of various product types to environmental emissions. The downward trend in WO use from 2010 to 2016 is reflected in declining concentrations in wastewater influent during the same period. Uncertainty remains about future levels of D5, once phasing out WO products is complete. The probabilistic model in conjunction with high‐tier data of consumer habits is a promising high‐tier tool for the characterization of complex emission scenarios of personal care ingredients. Integr Environ Assess Manag 2019;00:1–12. © 2019 SETAC

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Section: Introductionsupporting

confidence: 66%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Estimation of the Contribution Made to Down‐the‐Drain Emissions of D5 by Personal Care Product Categories in the European Union

Franco¹,

Egmond

2019

Integr Envir Assess & Manag

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Bio-based alternatives to volatile silicones: Relationships between chemical structure, physicochemical properties and functional performances

Goussard¹,

Aubry²,

Nardello‐Rataj³

2022

Advances in Colloid and Interface Science

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Multi-pathway exposure modeling of chemicals in cosmetics with application to shampoo

Ernstoff

Fantke

Csiszar

et al. 2016

Environment International

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We present a novel multi-pathway, mass balance based, fate and exposure model compatible with life cycle and high-throughput screening assessments of chemicals in cosmetic products. The exposures through product use as well as post-use emissions and environmental media were quantified based on the chemical mass originally applied via a product, multiplied by the product intake fractions (PiF, the fraction of a chemical in a product that is taken in by exposed persons) to yield intake rates. The average PiFs for the evaluated chemicals in shampoo ranged from 3×10(-4) up to 0.3 for rapidly absorbed ingredients. Average intake rates ranged between nano- and micrograms per kilogram bodyweight per day; the order of chemical prioritization was strongly affected by the ingredient concentration in shampoo. Dermal intake and inhalation (for 20% of the evaluated chemicals) during use dominated exposure, while the skin permeation coefficient dominated the estimated uncertainties. The fraction of chemical taken in by a shampoo user often exceeded, by orders of magnitude, the aggregated fraction taken in by the population through post-use environmental emissions. Chemicals with relatively high octanol-water partitioning and/or volatility, and low molecular weight tended to have higher use stage exposure. Chemicals with low intakes during use (<1%) and subsequent high post-use emissions, however, may yield comparable intake for a member of the general population. The presented PiF based framework offers a novel and critical advancement for life cycle assessments and high-throughput exposure screening of chemicals in cosmetic products demonstrating the importance of consistent consideration of near- and far-field multi-pathway exposures.

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Evaporation of decamethylcyclopentasiloxane (D5) from selected cosmetic products: Implications for consumer exposure modeling

Cited by 8 publications

References 33 publications

Estimation of the Contribution Made to Down‐the‐Drain Emissions of D5 by Personal Care Product Categories in the European Union

Estimation of the Contribution Made to Down‐the‐Drain Emissions of D5 by Personal Care Product Categories in the European Union

Bio-based alternatives to volatile silicones: Relationships between chemical structure, physicochemical properties and functional performances

Multi-pathway exposure modeling of chemicals in cosmetics with application to shampoo

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