Evaporation‐Induced rGO Coatings for Highly Sensitive and Non‐Invasive Diagnosis of Prostate Cancer in the PSA Gray Zone

Wang, Binshuai; Zhang, Shudong; Meng, Jing; Min, Li; Luo, Jing; Zhu, Zhongpeng; Bao, Han; Zang, Ruhua; Deng, Shaohui; Zhang, Fan; Ma, Lulin; Wang, Shutao

doi:10.1002/adma.202103999

Cited by 24 publications

(37 citation statements)

References 31 publications

(30 reference statements)

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“…CTC isolation has a number of performance characteristics, including capture efficiency, enrichment factor, and cell viability [31] , [32] . To verify that the fabricated chips can selectively separate the CTCs based on their size for different cancer types, we tested the performance of our micro-devices using two cancer cell lines: PC3, a human prostate cancer cell line and a highly invasive [33] , [34] , and MDA-MB-231, a human breast cancer cell line, and highly invasive [35] , [36] . The DAPI-stained MDA-MB-231 cells (10 5 cells/mL) trapped within the rectangle and lozenge devices are shown in Fig.…”

Section: Resultsmentioning

confidence: 99%

A micropillar array-based microfluidic chip for label-free separation of circulating tumor cells: The best micropillar geometry?

Rahmanian

Hematabad

Askari

et al. 2023

Journal of Advanced Research

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Section: Resultsmentioning

confidence: 99%

A micropillar array-based microfluidic chip for label-free separation of circulating tumor cells: The best micropillar geometry?

Rahmanian

Hematabad

Askari

et al. 2023

Journal of Advanced Research

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“…[48] However, in contrast to enhancing output power density, much less effort has been devoted to developing antifouling capability for lamellar nanofluidic membranes. Considering that surface topography is a key factor modulating adhesion on surfaces, [49] the superstructure design may influence the surface fouling behavior of SSGOMs to a certain degree. In this regard, we investigated the biofouling resistance of PGOM and SSGOMs via examining the adhesion of Chlorella pyrenoidosa, [50] a typical fouling microorganism widely distributed in natural waters.…”

Section: Resultsmentioning

confidence: 99%

Topologically Programmed Graphene Oxide Membranes with Bioinspired Superstructures toward Boosting Osmotic Energy Harvesting

Liu

Zhang

Fang

et al. 2022

Adv Funct Materials

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The emergence of lamellar nanofluidic membranes offers feasible routes for developing highly efficient, mechanically robust, and large‐scale devices for osmotic energy harvesting. However, inferior ion permeability associated with their relatively long channels limits ionic flux and restricts their output performance. Herein, a superstructured graphene oxide membrane is developed to allow programmable topological variation in local geometry and contain laminar spaces inside. Such deliberate design offers excess specific area as well as nanofluidic channels to modulate transmembrane ionic transportation while concomitantly retaining similar nanoconfined environment in contrast to planar ones, leading to considerable enhancement of ionic permeability without compromising selectivity. This can be highly favorable in terms of osmotic energy harvesting, where the superstructured membranes offer a power output much higher than those of conventional planar ones. Besides, the superstructure design also endows the resulting membranes with benign biofouling resistance, which can be crucial to their long‐term usage in converting osmotic energy. This study highlights the importance of membrane topographies and presents a general design concept that could be extended to other nanoporous membranes to develop high‐performance nanofluidic devices.

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“…PSA level and F/T-PSA value cannot distinguish cancer (red square) and non-cancer (green triangle) patients using the t-distributed stochastic neighbor embedding (t-SNE) model. [29,57] After adding CTCs number parameters, cancer and non-cancer patients can be well distinguished (Figure 4f). A receiver operating characteristic (ROC) curve was used to compare the CTCs approach with the PSA approach and F/T-PSA approach.…”

Section: Ctcs-based Liquid Biopsy For Clinical Prostate Cancer Diagnosismentioning

confidence: 99%

Interfacial Polymerization Produced Magnetic Particles with Nano‐Filopodia for Highly Accurate Liquid Biopsy in the PSA Gray Zone

Zhang,

Song

et al. 2023

Advanced Materials

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Magnetic particles are leading separation materials for biological purification and detection. Existing magnetic particles, which almost rely on molecule‐level interactions, however, often encounter bottlenecks in highly efficient cell‐level separation due to the underestimate of surface structure effects. Here, immune cell‐inspired magnetic particles with nano‐filopodia (NFMPs) produced by interfacial polymerization for highly efficient capture of circulating tumor cells (CTCs) and further accurate clinical diagnosis of prostate cancer are reported . The unprecedented construction of nano‐filopodia on polymer‐based magnetic particles is achieved by introducing electrostatic interactions in emulsion interfacial polymerization. Due to the unique nano‐filopodia, the NFMPs allow remarkably enhanced CTCs capture efficiency (86.5% ± 2.8%) compared with smooth magnetic particles (SMPs, 35.7% ± 5.7%). Under the assistance of machine learning by combining with prostate‐specific antigen (PSA) and free to total PSA (F/T‐PSA), the NFMPs strategy demonstrates high sensitivity (100%), high specificity (93.3%), and a high area under the curve (AUC) value (98.1%) for clinical diagnosis of prostate cancer in the PSA gray zone. The NFMPs are anticipated as an efficient platform for CTCs‐based liquid biopsy toward early cancer diagnosis and prognosis evaluation.

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Evaporation‐Induced rGO Coatings for Highly Sensitive and Non‐Invasive Diagnosis of Prostate Cancer in the PSA Gray Zone

Abstract: Research data are not shared.

Cited by 24 publications

References 31 publications

A micropillar array-based microfluidic chip for label-free separation of circulating tumor cells: The best micropillar geometry?

A micropillar array-based microfluidic chip for label-free separation of circulating tumor cells: The best micropillar geometry?

Topologically Programmed Graphene Oxide Membranes with Bioinspired Superstructures toward Boosting Osmotic Energy Harvesting

Interfacial Polymerization Produced Magnetic Particles with Nano‐Filopodia for Highly Accurate Liquid Biopsy in the PSA Gray Zone

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