In order to achieve high efficiency of new fuel engine, a mathematical model based on mass, momentum and energy equations was developed to describe the motion and evaporation characteristics of a single ethanol droplet in high temperature nitrogen environment. By comparing the numerical results with experimental data, the validity of model was confirmed. The relationships of droplet temperature, velocity, size with time and movement distance under different ambient pressures were analyzed. The calculated results indicate that with a higher ambient pressure, the droplet temperature is higher, the droplet velocity declines faster, the movement distance is shorter; the evaporation rate is slower, and the droplet life is longer. Within the distance where the droplet velocity continuous variation, the droplet temperature rises gradually, the droplet size expands slightly, and with the increase of ambient pressure, the droplet expansion is more significant.