Evans' Syndrome and Pregnancy

Silverstein, Murray N.; Aaro, Leonard A.; Kempers, Roger D.

doi:10.1097/00000441-196608000-00012

Cited by 19 publications

(7 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…8 patients with known AIH who became pregnant produced live children in six in stances [10,16,18,19,22]; 2 infants were stillborn [20,21], 2 of the living children [16,18] were mildly affected with haemolytic dis ease and required no treatment. 1 of the still born infants was severely affected with hae molytic disease [20] but the cause of death in the other was probably not related to the maternal AIH [21].…”

Section: Discussionmentioning

confidence: 99%

“…A distinction must be made between patients with AIH occurring 'de novo' during pregnancy and presumably being caused by it [2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17], and patients with known AIH who become preg nant [10,16,[18][19][20][21][22], The serological abnor malities in all our cases were discovered dur ing pregnancy; in 6 of them no autoanti bodies had been detected earlier in the preg nancy (although in one, D.M., a viral infec tion during pregnancy could have stimu lated the AIH), and in a further 5 patients there were no detectable autoantibodies when tested prior to the pregnancy in ques tion (table I). The possibility that the asso ciation is mere coincidence is most unlikely as our figures suggest that AIH occurs at least four times more frequently during preg nancy since in the non-pregnant female pop ulation of the same age range (16-40 years) the incidence of AIH was 0.4 per 100,000.…”

Section: Methodsmentioning

confidence: 99%

See 1 more Smart Citation

Erythrocyte Autoantibodies, Autoimmune Haemolysis and Pregnancy

Sokol¹,

Hewitt²,

Stamps³

1982

Vox Sanguinis

View full text Add to dashboard Cite

The clinical and serological records of 20 pregnant patients with erythrocyte autoantibodies were critically reviewed and analysed. This series, the largest reported, confirmed an association between erythrocyte autosensitization and pregnancy, and suggested that this occurred on an average of 1 in 50,000 pregnancies. The clinical presentation varied from severe haemolytic anaemia to serological abnormalities discovered during the routine testing of well patients; overt haemolysis was present in 7 cases. Treatment was only necessary in 3 patients where the haemolysis was severe. 3 infants were mildly affected with haemolytic disease due to the maternal autoantibodies crossing the placenta but no treatment was needed. The risks to the infant were increased when other active autoimmune conditions (e.g., systemic lupus erythematosus) were present. With early diagnosis and appropriate treatment, the outlook for mother and child is good.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Erythrocyte Autoantibodies, Autoimmune Haemolysis and Pregnancy

Sokol¹,

Hewitt²,

Stamps³

1982

Vox Sanguinis

View full text Add to dashboard Cite

show abstract

“…Later the patient became pregnant and the disease relapsed with isolated thrombocytopenia during 8th week of gestational age, which responded to steroid treatment. 4 In our case thrombocytopenia was encountered during 28 th week of gestational age and entered remission with high dose steroid treatment. Obviously the role of splenectomy in the treatment of Evans syndrome is not clearly proven because the response rate is frequently low and transient.…”

Section: Discussionmentioning

confidence: 51%

Thrombocytopenia in Pregnancy: Evans Syndrome an Unconventional Diagnosis, Evans Syndrome in Pregnancy: Case Report

Seval¹,

Acar²

2016

Turkiye Klinikleri J Gynecol Obst

View full text Add to dashboard Cite

“…Seis pacientes cursaban con su primera gestación (6, 11-15), una con la tercera (10), una con la cuarta (16), una con la quinta gestación (6), y para una de las pacientes no hay información al respecto (9). Se informó la segunda gestación de una de las pacientes reportadas inicialmente como primigrávida (15).…”

Section: Resultsunclassified

“…En la revisión de los casos, sin embargo, se encuentran los siguientes desenlaces: cinco gestaciones llegaron a término (9,12,13,15,16), ninguna más allá de la semana 39. Cuatro de estos nacimientos fueron vaginales (9,13,15,16) y uno por cesárea de emergencia (12); no se presentaron desenlaces fatales para los fetos-recién nacidos en esos casos. Los demás fueron nacimientos pretér-mino (6,10,11,14,15), tres de estos fueron por cesárea de emergencia (6,14).…”

Section: Resultsunclassified

Síndrome de Evans y embarazo en la adolescencia: reporte de un caso y revisión de la literatura

Viveros‐Carreño

Baños

2016

Rev. Colomb. Obstet. Ginecol.

View full text Add to dashboard Cite

Objetivo: presentar el caso de una gestante adolescente con síndrome de Evans, y hacer una revisión de la literatura respecto a su tratamiento y pronóstico durante el embarazo.Materiales y métodos: se presenta el caso de una paciente adolescente embarazada con síndrome de Evans, manejada en nuestra unidad, ubicada en un hospital de segundo nivel de referencia en Bogotá (Colombia); se describe la historia clínica, su diagnóstico, manejo y desenlace, y se realiza una revisión de la literatura con énfasis en su tratamiento y pronóstico. Se realizó una búsqueda de literatura utilizando las bases de datos Medline vía PubMed, Embase y la Biblioteca Cochrane a mayo de 2016. Las palabras clave utilizadas fueron “anemia hemolítica autoinmune”, “trombocitopenia”, “síndrome de Evans” y “embarazo”, en español o inglés, sin límite por año de publicación.Resultados: se encontraron 79 publicaciones en la búsqueda en Medline y 61 en Embase. De estas, 13 estudios estaban directamente relacionados con el tema. Uno de los artículos corresponde a una revisión sistemática de la literatura y los demás a reportes de caso. Todos los reportes de caso encontrados están incluidos en la revisión sistemática. El síndrome de Evans se debe sospechar cuando se presenta trombocitopenia y hemólisis en la mujer gestante. La patología tiene un curso variable durante el embarazo y amerita un control estricto materno-fetal. Se dispone de alternativas que incluyen el uso de corticoides, gamaglobulina intravenosa y, en algunos casos, el manejo quirúrgico con esplenectomía.Conclusiones: el síndrome de Evans es una patología rara durante la gestación, se requieren más estudios respecto al tratamiento y pronóstico de la enfermedad que permitan guiar su manejo.

show abstract

Evans' Syndrome and Pregnancy

Cited by 19 publications

References 0 publications

Erythrocyte Autoantibodies, Autoimmune Haemolysis and Pregnancy

Erythrocyte Autoantibodies, Autoimmune Haemolysis and Pregnancy

Thrombocytopenia in Pregnancy: Evans Syndrome an Unconventional Diagnosis, Evans Syndrome in Pregnancy: Case Report

Síndrome de Evans y embarazo en la adolescencia: reporte de un caso y revisión de la literatura

Contact Info

Product

Resources

About