Evaluierung individueller, in der CAD/CAM-Technik gefertigter Bioverit®-Keramik-Implantate zur Wiederherstellung mehrdimensionaler kraniofazialer Defekte am menschlichen Schädel

Siebert, H.; Schleier, Peter; Beinemann, Jörg; Fried, Wolfgang; Zenk, W; Schumann, D.

doi:10.1007/s10006-006-0687-z

Cited by 18 publications

(10 citation statements)

References 32 publications

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“…8 mm); (d) specific functionalizations of a middle ear prosthesis with a mesoporous silica coating, which is used for a site-specific attachment of a growth factor and for local drug delivery. [21][22][23][24][25] A typical middle ear prosthesis made from this material is shown in Fig. 1c.…”

Section: Thomas Lenarzmentioning

confidence: 99%

Mesoporous silica films as a novel biomaterial: applications in the middle ear

et al. 2013

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In this tutorial review we present the process of the development of functional implants using mesoporous silica. The different steps from chemical synthesis and physicochemical characterization followed by in vitro testing in cell culture assays to clinically relevant in vivo animal studies are examined. Since the end of the 1990s, mesoporous silicas have been considered as biomaterials. Numerous investigations have demonstrated their non-toxic and biocompatible properties. These qualities in combination with the unique properties of high surface area and pore volume, uniform and tunable pore sizes and chemical modifiability are the reasons for the great scientific interest in this field. Here we show that besides bulk materials or mesoporous silica nanoparticles, mesoporous silica films are highly promising as coatings on medical prostheses or implants. We report on the development of functionalized mesoporous silica materials specifically for middle ear applications. Middle ear prostheses are used to restore the sound transmission through this air-filled cavity when the small bones of the middle air (the ossicular chain) have been destroyed by disease or by accidents. In addition to optimal restoration of sound transmission, this technique bears several challenges, e.g. an ongoing bacterial infection or the displacement of the prosthesis due to insufficient fixation. To improve the healing process, a mesoporous silica coating was established on ceramic middle ear prostheses, which then served as a base for further functionalizations. For example, the bone growth factor BMP2 was locally attached to the coating in order to improve the fixation of the prosthesis by forming a bony connection to the remainder of the ear bones. Further, an implant-based local drug delivery system for the antibiotic ciprofloxacin was developed with the aim of fighting bacterial infections. Further possibilities using mesoporous silica nanoparticles as part of a composite on an implant are briefly discussed. Key learning pointsThe way from clinical problems to improved implant materials: materials development, in vitro and in vivo testing. Establishment of mesoporous thin silica films on ceramic surfaces. Degradation of mesoporous silica films in physiological medium. Implant-carried mesoporous silica films as drug delivery systems. Implant-based delivery of biomolecules using mesoporous silica coatings.

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Section: Thomas Lenarzmentioning

confidence: 99%

Mesoporous silica films as a novel biomaterial: applications in the middle ear

et al. 2013

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“…Just as titanium implants, the glass-ceramic Bioverit ® established in ear-surgery by Beleites et al [10] is available as an individual CAD/CAM implant for craniofacial reconstruction showing good clinical results [11], [137]. The implants allow intraoperative remodelling and adjustment with a bur and, in opposite to titanium implants, do not show thermosensitivity.…”

Section: Bone Substitutesmentioning

confidence: 99%

Biomaterials for craniofacial reconstruction

Neumann

2009

GMS Current Topics in Otorhinolaryngology - Head and Neck Surgery; 8:Doc08; ISSN 1865-1011

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“…So konnte im Tierversuch eine calciumphosphatreiche Schicht zwischen Knochen und Bioverit I beobachtet werden, was für eine chemische Bindung spricht [39]. Glaskeramik-Granulat kann intraoperativ in der erforderlichen Menge eingebracht und dann mit Salzlösung gebunden werden und ist somit variabler verwendbar als Platten und Blöcke, die präoperativ zugeschnitten werden müssen [37]; allerdings sind Letztere für präoperativ anhand virtueller Modelle präformierte Implantate geeignet [40,41]. Gegenüber Titan ist die Wärmeleitung deutlich reduziert, und Artefakte in der Bildgebung werden vermieden [40].…”

Section: Titannetzeunclassified

“…a Der Navigationspointer (grün) zeigt die exakte Übereinstimmung der Oberflächen von Implantat und präoperativem Knochen (orange). b Rechts Keramik-Implantat (Bioverit II ) in situ mit Titanplatten fixiert (nach [40]).…”

Section: Nichtmetallische Implantateunclassified

Biomaterialien in der Schädelbasischirurgie

Maier¹

2009

Laryngo-Rhino-Otol

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Reconstruction materials and techniques for the skull base have undergone rapid developments and differentiation in recent years. While mostly autotransplants, collagens or resorbable alloplastic materials are preferred for duraplasties, pronounced organ-specific differences can be observed IN the reconstruction of hard tissues. The use of polymethylmethacryl bone cement, once wide-spread, has decreased greatly due to the release of toxic monomers. Bony autotransplants are still used primarily for smaller skull-base defects, intraoperatively formable titanium meshes may be also used for larger fronto- or laterobasal reconstructions of bony defects. Defects in visible areas are increasingly closed with preformed titanium or ceramic implants, which are planned and fitted to the individual patient using preoperative CT imaging. At the skull base, this applies especially to reconstructions of the frontal sinus. For extensive reconstructions of the orbita, titanium meshes and non-resorbable plastics have proven valuable, in closing smaller defects especially of the orbital floor, resorbable implants based on Polyglactin 901 are also used.

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Evaluierung individueller, in der CAD/CAM-Technik gefertigter Bioverit®-Keramik-Implantate zur Wiederherstellung mehrdimensionaler kraniofazialer Defekte am menschlichen Schädel

Cited by 18 publications

References 32 publications

Mesoporous silica films as a novel biomaterial: applications in the middle ear

Mesoporous silica films as a novel biomaterial: applications in the middle ear

Biomaterials for craniofacial reconstruction

Biomaterialien in der Schädelbasischirurgie

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