Evaluations of the radial peripapillary, macular and choriocapillaris microvasculature using optical coherence tomography angiography in patients with systemic sclerosis

Küçük, Mehmet Fatih; Yaprak, Lütfiye; Erol, Muhammet Kazım; Ayan, Ayşe; Kök, Mehmet

doi:10.1016/j.jfo.2021.06.009

Cited by 3 publications

(3 citation statements)

References 35 publications

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“…There are two studies in the literature evaluating CVI in SSc; however, they refer to the macular area and, the results are inconsistent ( 21 , 27 ). In the peripapillary region, only the vascular density parameters and optic nerve head (ONH) parameters obtained using OCT-A were examined in patients with SSc ( 17 , 19 , 23 ), which is associated mostly with retinal and not choroidal circulation due to the functional and structural heterogeneity of these circulatory systems ( 24 ). In recent years, interest in peripapillary choroid thickness has increased.…”

Section: Introductionmentioning

confidence: 99%

“…However, the characteristics of the choroid in this area are much poorer than those of the macular area. Studies have revealed thinner peripapillary choroidal thickness not only among patients with NTG and primary open-angle glaucoma (POAG), ( 23–26 ), but also in other diseases, such as multiple sclerosis ( 27 ), chronic obstructive pulmonary disease ( 28 ), high myopia ( 29 ), or in patients with vitamin D deficiency ( 30 ). In contrary, other studies have shown a thicker peripapillary choroid in some diseases, such as nonarteritic anterior ischemic optic neuropathy ( 31 ), Parkinson’s disease ( 32 ) and retinal vein occlusions at diagnosis, followed by a decrease at an early follow-up stage ( 33 ).…”

Section: Introductionmentioning

confidence: 99%

“…Retinal and choroidal microvascular impairments in SSc patients have been confirmed using fluorescence angiography (FA) (15), optical coherence tomography (OCT) (16)(17)(18)(19)(20), and OCT-angiography (OCT-A) (21)(22)(23)(24)(25). Most studies on choroidal macular thickness have found that patients with SSc have a significantly thinner macular choroid than healthy subjects, probably due to chronic vascular damage (16-18, 20, 24-26).…”

Section: Introductionmentioning

confidence: 99%

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Peripapillary choroidal vascularity index and thickness in patients with systemic sclerosis

Pieklarz,

Gińdzieńska-Sieśkiewicz,

Zawadzka

et al. 2023

Front. Med.

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IntroductionPatients with systemic sclerosis (SSc) present an increased risk of developing glaucomatous optic neuropathy (GON). We investigated peripapillary choroidal parameters and peripapillary retinal nerve fiber layer (RNFL) thickness using spectral domain optical coherence tomography (SD-OCT) to determine the relationships of these factors with clinical variables.MethodsA total of 33 patients with SSc were enrolled and compared to 40 controls. After obtaining circular scans around the optic disc, the global and quadrant peripapillary choroidal thickness (pCT) and RNFL thickness were measured. Additionally, the peripapillary choroidal vascularity index (pCVI), which allows for a quantitative analysis of the choroidal vasculature, was determined.ResultsNo significant differences were found in pCT and RNFL thickness between patients with SSc and controls, or within SSc subtypes (diffuse cutaneous systemic sclerosis (dcSSc) compared to limited cutaneous systemic sclerosis (lcSSc)) (p > 0.05). The pCVI was significantly lower in patients with SSc than in control subjects (64.25 ± 1.94 vs.65.73 ± 2.12, p < 0.001).ConclusionOur results suggest that the statistically significant decrease in pCVI in patients with SSc compared to the control group is probably due to a decrease in the vascular layer, which would partially explain an increased risk of GON in patients with SSc.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Peripapillary choroidal vascularity index and thickness in patients with systemic sclerosis

Pieklarz,

Gińdzieńska-Sieśkiewicz,

Zawadzka

et al. 2023

Front. Med.

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Posterior Segment Evaluation of Patients with Systemic Sclerosis Using Optical Coherence Tomography Angiography

El-Hameed,

Hammouda,

Esmail

et al. 2024

Preprint

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Background systemic sclerosis is an autoimmune disease with ocular affection. This study is for the evaluation of the retinal microvascular changes in systemic sclerosis patients by using the OCTA. Methods This prospective observational case-control study comprised twenty eyes of twenty systemic sclerosis patients as group I and another twenty eyes of twenty normal subjects as group II. All study members were examined with optical coherence tomography angiography in addition to a full ophthalmic examination. Results Both groups had more females gender than males without significant differences between them. Also, the mean age difference was statistically insignificant, with nearly the same range, which was 30 to 59 years in group I and 32 to 58 years in group II. Analysis of OCTA parameters revealed significantly lower differences in group I in the superficial vessel density at parafoveal, temporal, superior, and nasal regions. Lower values were recorded in group I at all zones of the deep layer except at the foveal zone. Vessel density measurements of the choriocapillaris revealed no statistically significant differences between groups in all zones. Conclusions The OCTA has demonstrated impairment of retinal microperfusion, confirming the presence of vascular damage. The duration of the disease had correlated with the DCP-VD and choriocapillaris VD. So, once systemic sclerosis has been diagnosed, microvascular retinal and choroidal evaluations should be considered to identify any sub-clinical alterations using OCTA.

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Connective tissue disorders and eye: A review and recent updates

Asif

Kalra

Sharma

et al. 2023

Indian Journal of Ophthalmology

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Collagen vascular disorders (CVDs), also known as connective tissue diseases (CTDs), are a heterogeneous group of entities that affect the connective tissues and are capable of causing end-organ damage to multiple systems, primarily cardiopulmonary and musculoskeletal. However, the occurrence and severity are highly variable among patients. Ocular involvement occurs in a significant number of these disorders and may precede the onset of other extraocular features, thereby serving as an important marker in the diagnosis of these diseases. A timely and accurate diagnosis enables the management of complications. CTDs are primarily immune-mediated inflammatory diseases; however, classifications have encompassed heritable disorders affecting collagen-containing structures and disorders of vascular development. A review of literature published until 25 January 2022 and collected from various databases using the relevant keywords was conducted. All publications (original articles, review articles, as well as case reports) describing the ocular features in CTDs were studied in detail. The objective of this review is to recognize the common ophthalmic presentations of various autoimmune and heritable CTDs, distinguish them from overlapping diseases, elaborate on the prognosis and management of these varied eye presentations, and deliberate on their impact on other ophthalmic surgeries.

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Evaluations of the radial peripapillary, macular and choriocapillaris microvasculature using optical coherence tomography angiography in patients with systemic sclerosis

Cited by 3 publications

References 35 publications

Peripapillary choroidal vascularity index and thickness in patients with systemic sclerosis

Peripapillary choroidal vascularity index and thickness in patients with systemic sclerosis

Posterior Segment Evaluation of Patients with Systemic Sclerosis Using Optical Coherence Tomography Angiography

Connective tissue disorders and eye: A review and recent updates

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