Evaluation the effect of formulation made of Talh honey, whey protein and collagen on acute excisional skin wound healing in Wistar male rat

Abstract

Objectives: This study evaluated the ability of using formulation contains Talh honey, whey protein and collagen on wound healing using animal model.
 Methods: 24 Wistar male rats were divided into four groups of 6 rats each as follow; G1 (not treated), G2 (treated with Manuka honey), G3 (treated with Povidone iodine ointment 5%), and G4 (treated with tested formulation). Excisional wound was induced in rat’s dorsal skin. The duration of the study was 18 days. Morphological and histological examination was performed for all groups.
 Results: The tested formula showed reduction in the duration of the inflammatory phase of wound healing when compared to other groups.
 Conclusion: Results from this study indicated the therapeutic potential of the tested formula, which contains natural component, in wound healing as using other therapeutic products. The tested formula is affordable for wide range of patients. Further studies are required to investigate the different mechanisms behind the therapeutic properties of each treatment.

Studies on bioactivities of Manuka and regional varieties of honey for their potential use as natural antibiotic agents for infection control related to wound healing and in pharmaceutical formulations

“…All rats were individually caged and Groups 2, 3, and 4 had their materials reapplied every 2 days post-operation. The experimental honey formulation indicated a safe therapeutic potential with an accelerated wound contraction and closure rate, while no indication of infection due to bacterial or fungal pathogens was observed across the 18 days post-operation comparable to an antibiotic material [58] .…”

“…Consistently, Yamani and Fakiah evaluated the acute excisional wound healing capacity of a formulation of Tahl honey, whey protein, and collagen in male rat models compared with treatment using Manuka honey and a Povidone 5% iodine ointment [58] . Twenty-four male rats were divided into four groups (n = 6) as follows: group 1 (no treatment/negative control), group 2 (Manuka honey), group 3 (Povidone 5% iodine ointment), and group 4 (Formulation of Tahl honey, whey protein, and collagen).…”