Evaluation the Effect of Diclofenac Sodium on Inh-Induced Seizures

Abstract

Epilepsy is a common and a complex neurological disorder that is characterized by a persisting tendency to generate seizures which affect quality of life. However neuro inflammation may be included as a major contributor to seizure that may be treated via non-steroidal anti-inflammatory drugs. The results: the effect of pre-administration of diclofenac sodium intraperitoneally at a dose of 10 mg/kg on the onset of action was highly significant in comparison with first group p-value < 0.001 and was significant and strongly significant in comparison with both diazepam and the combination groups (p-value = 0.003 and 0.001 respectively). The time recorded as a seizure duration which belong to the effect of diclofenac sodium was 57.4 ± 8.142 seconds with highly significant effect against all remaining groups. However, it was revealed that no death was happening in diclofenac sodium group, but it reaches to 100% in diazepam group while in group of combined treatment it was 60% through 24 hours that followed the study period. AimsConclusion: Diclofenac sodium (non-selective NSAIDs) may display protection against seizures, but this protection is revealed to be a lesser extent when it combined with diazepam.