Evaluation Study of Sustained Release Ocular Insert of Brimonidine Tartrate and Timolol

Mujoriya, Rajesh; Kshirsagar, M. D.

doi:10.5958/0975-4377.2016.00032.x

Cited by 2 publications

(1 citation statement)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The usual method for treating eye infections is the instillation of aqueous antibiotic solutions (eye drops) directly onto the ocular surface (Watson et al, 2018;Mandal et al, 2022). However, this approach has limitations because the antibiotics don't stay in the eye for long, leading to low efficacy (Dave et al, 2013;Mujoriya & Kshirsagar, 2016). This requires frequent local instillation of drugs, which causes an undesirably high concentration of drug or preservative at the site of action (Kumar & Sharma, 2013).…”

Section: Introductionmentioning

confidence: 99%

Formulation and Evaluation of Ocusert Embeded with Ciprofloxacin Loaded Nanoparticles

Shaikh,

Khan,

Shaikh

et al. 2024

IJALSR

View full text Add to dashboard Cite

Ophthalmic drug delivery is very challenging. Upon the application of conventional topical ophthalmic formulations, a significant portion of the administered dose goes to waste due to the existence of various ophthalmic barriers. There is a swift elimination of the applied solution from the anterior part of the eyes through the nasolacrimal duct to the nasal cavity. The aim of this study was to develop an ocusert embedded with ciprofloxacin-loaded nanoparticles to increase patient compliance by improving local delivery of the drug. Ciprofloxacin-loaded Eudragit RL PO polymeric nanoparticles were prepared and evaluated for particle properties. These drug-loaded polymeric nanoparticles were embedded in an ocusert made of carboxymethylcellulose. Various properties of ocuserts, like film endurance, surface pH, disintegration time, and sterility, were studied. A drug-loaded nanoparticle-embedded ocusert was found to be a suitable system to improve ophthalmic drug delivery. The nanoparticles' particle size, polydispersity index (PDI), entrapment efficiency, and in vitro drug release were all assessed. The generated ocuserts underwent screening for sterility, drug content, weight variability, folding durability, thickness, surface pH, and disintegration time. In order to gain insight into the process by which drugs release from the formulations, the in vitro drug release from the preparations was examined using a standard Abron Visking semipermeable membrane.

show abstract

Section: Introductionmentioning

confidence: 99%

Formulation and Evaluation of Ocusert Embeded with Ciprofloxacin Loaded Nanoparticles

Shaikh,

Khan,

Shaikh

et al. 2024

IJALSR

View full text Add to dashboard Cite

show abstract

Preparation and In-vitro Evaluation of Timolol Maleate Loaded Ocular inserts by using various polymers

Dayoub

Laham

2023

RJPT

View full text Add to dashboard Cite

The anatomy physiology and biochemistry of the eye render this organ impervious to foreign substances. Ocusert system was firstly developed in 1975 in the USA. It is a flat, flexible, solid and semisolid device which consists of drug reservoir by using various polymers. In the present study Timolol maleate loaded ocular inserts were prepared using different polymers (Methylcellulose, Hydroxypropyl methylcellulose, Eudragit, Ethyl cellulose, Polyvinyl pyrrolidone) by solvent casting method for the treatment of glaucoma. Glycerin, Polyethylene glycol and Dibutyl phthalate were used as plasticizers in different ratios. The prime objective of ocuserts formulating is to enhance therapeutic effect through continuous controlled delivery of ophthalmically active drug to the eye. The physiochemical parameters like thickness, weight, surface pH, folding endurance, % moisture absorption, % moisture loss and drug content were evaluated. In-vitro drug release studies were carried out using a Franz diffusion cell like model. Drug-polymer interactions were investigated by Fourier transform infrared (FTIR) spectroscopy. It was found that the higher the polymer percentage in the formula, the greater the weight and thickness of the film. The mechanical properties of the films reveal that the formulations (F2, F3, F4, F5, F6, F7 and F8) were strong, elastic with smooth surface and appropriate weight for ocular use. In addition to having surface pH that matches the requirements of the ocular dosage forms. It has also been shown that the formulas with hydrophobic polymers have low ability to absorb moisture as well as low moisture content. F4 (Eudragit RL 100 10%) gave sustained drug release with most of the drug being released after 8 hours (95.331%). The release profile of F4 followed the Korsmeyer-Peppas model and correlation coefficient (R2 = 0.992). FTIR studies did not show any evidence of interaction between the drug and the polymers.

show abstract

Evaluation Study of Sustained Release Ocular Insert of Brimonidine Tartrate and Timolol

Cited by 2 publications

References 0 publications

Formulation and Evaluation of Ocusert Embeded with Ciprofloxacin Loaded Nanoparticles

Formulation and Evaluation of Ocusert Embeded with Ciprofloxacin Loaded Nanoparticles

Preparation and In-vitro Evaluation of Timolol Maleate Loaded Ocular inserts by using various polymers

Contact Info

Product

Resources

About