Evaluation on blood coagulation and C-reactive protein level among children with mycoplasma pneumoniae pneumonia by different chest imaging findings

Abstract

Mycoplasma pneumoniae infection may induce a systemic hypercoagulable abnormality, like organ embolism and infarction. Indexes of blood coagulation and C-reactive protein (CRP) have been reported different between healthy people and mycoplasma pneumoniae pneumonia (MPP) patients, but this difference in MPP patients with different chest imaging findings has rarely been reported. We performed a retrospective study of 101 children with MPP and 119 controls, combined with radiological examination and blood tests, to compare the blood coagulation and CRP level among MPP children with different chest imaging findings. For the MPP children with different chest imaging findings, there were significant differences in CRP, fibrinogen (FIB) and D-dimer (D-D) levels among subgroups (P = .004, P = .008 and P < .001 respectively). The CRP level in group of interstitial pneumonia was significantly higher than that in groups of bronchopneumonia and hilar shadow thickening (P = .003 and P = .001 respectively). And the FIB and D-D values in group of lung consolidation were significantly higher than that in the other 3 groups (all P < .05). When compared with controls, the white blood cell, CRP, FIB, and D-D levels in MPP children were significantly higher, and the activated partial thromboplastin time and thrombin time levels were significantly lower (all P < .05). Our results showed that CRP level changed most significantly in group of interstitial pneumonia, whereas FIB, D-D levels changed most significantly in the lung consolidation group.

Efficacy and inflammatory levels (IL-6, IL-10) of adjuvant application of vitamin-A in the treatment of pediatric Mycoplasma pneumoniae pneumonia: a systematic review and meta-analysis

“…VitA is also an important regulatory factor for cell differentiation and proliferation. During mycoplasma infection, VitA may promote repair and recovery by regulating the proliferation and differentiation of damaged lung tissue cells, which helps to accelerate the disappearance of lung rales and alleviate coughing and fever ( 21 ). Although the role of VitA in the immune system and respiratory infections has been preliminarily confirmed, the specific treatment effect still needs to consider the impact of individual differences on the efficacy of VitA.…”

Role of Intracellular Pulmonary Pathogens during SARS-CoV-2 Infection in the First Pandemic Wave of COVID-19: Clinical and Prognostic Significance in a Case Series of 1200 Patients

“…The laboratory tests showed that co-infections caused an increase in D-dimer and fibrinogen values, causing a higher risk of thrombosis. MP and CP are bacteria known to evoke hypercoagulability [18,19]. Furthermore, co-infections increase the risk of thrombosis compared to patients with COVID-19 infection alone.…”

“…Furthermore, co-infections increase the risk of thrombosis compared to patients with COVID-19 infection alone. The D-dimer assessment is strongly recommended in routine anticoagulant prophylaxis [16][17][18][19][20].…”

Clinical characteristics and serum inflammatory markers of community‐acquired mycoplasma pneumonia in children

“…How to make clear the early diagnosis of MPP and accurately assess its severity is the focus of current pediatric research. It is widely believed that MP proliferates in respiratory epithelial cells by binding P1 protein to cilia, stimulates the production of pro‐inflammatory cytokines in airway mucosa, induces cellular inflammatory response and tissue damage and ultimately leads to changes in host immune function 5,6 . The imbalance of Th1/Th2 function after M. pneumoniae infection is an important immunological mechanism of MPP.…”

“…It is widely believed that MP proliferates in respiratory epithelial cells by binding P1 protein to cilia, stimulates the production of pro‐inflammatory cytokines in airway mucosa, induces cellular inflammatory response and tissue damage and ultimately leads to changes in host immune function. 5 , 6 The imbalance of Th1/Th2 function after M. pneumoniae infection is an important immunological mechanism of MPP. Therefore, it is important to study the results of serum inflammatory cytokines in children with MPP for guiding clinical treatment.…”