Evaluation of Xerostomia in Different Psychological Disorders: An Observational Study

Veerabhadrappa, Suresh Kandagal; Chandrappa, Pramod Redder; Patil, Snehal; Roodmal, Seema Yadav; Kumarswamy, Akshay; Chappi, Mounesh Kumar

doi:10.7860/jcdr/2016/19020.8437

Cited by 16 publications

(19 citation statements)

References 24 publications

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“…Results of some studies have indicated that different emotions can decrease or enhance salivary flow [ 7 ]. In addition, psychological disorders, like depression and anxiety, may be associated with xerostomia [ 8 ]. Anxiety and fear can potentially influence saliva secretion through pathways in the amygdala, hypothalamus, and brainstem [ 9 ].…”

Section: Introductionmentioning

confidence: 99%

Relationship among perceived stress, xerostomia, and salivary flow rate in patients visiting a saliva clinic

2018

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ObjectiveThis aimed to assess the potential role of chronic stress in saliva secretion, xerostomia, and oral health in a population attending a saliva clinic.Materials and methodsData of 114 patients who met the inclusion criteria and completed all questionnaires were analyzed in this study. Participants completed several validated questionnaires, including the Perceived Stress Scale, the Oral Health Impact Profile (OHIP-14), Xerostomia Inventory (XI), and Bother xerostomia Index (BI). Subsequently, the unstimulated, chewing-stimulated, and citric acid-stimulated saliva secretion rates were determined gravimetrically. Data were evaluated using Spearman’s correlation analysis and the Mann–Whitney U test.ResultsA significant correlation was observed between perceived stress and XI score (r = 0.312, p = 0.001), as well as between perceived stress and BI score (r = 0.334, p = 0.001). Stress levels also were significantly associated with OHIP-14 scores (r = 0.420, p < 0.001), but an association between experienced stress and salivary flow rate could not be established.ConclusionIn this population, perceived chronic stress seems to be related to several aspects of dry mouth, including the perception of dry mouth, suffering from dry mouth, and the impact on quality of life. These effects were independent of the use of psychotropic medication. No actual reduction in salivary flow was found. Further studies to explore the causal linkage of stress with xerostomia seem warranted.Clinical relevancePerceived chronic stress seems to be related with several aspects of dry mouth. This finding might be relevant in future prevention and treatment of xerostomia.

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Section: Introductionmentioning

confidence: 99%

Relationship among perceived stress, xerostomia, and salivary flow rate in patients visiting a saliva clinic

2018

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“…Moreover, anti-sialogic effects were observed in those taking drugs. 17,25 In this study, multivariate analysis revealed significant associations between xerostomia and medications or therapy, including analgesic NSAIDs, gabapentin, muscle relaxants, psychotherapeutic drugs, and radioactive iodine therapy. Despite the fact that some of the mechanisms remain unknown, medication-induced xerostomia is commonly caused by the altering of neural pathways that stimulate the secretion of saliva.…”

Section: Discussionmentioning

confidence: 65%

Factors Associated with Xerostomia in Non-Radiated Patients

Vathanophas

2019

Smj

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Objective: To identify factors significantly associated with xerostomia in non-radiated patients. Methods: Patients who attended the outpatient otolaryngology clinic at Siriraj Hospital (Bangkok, Thailand) with complaints of dry mouth were invited to join this study. Collected data included age, gender, body mass index, smoking status, alcohol use, underlying disease, and previous medication and/or therapy. Irradiated patients were excluded. Participants were classified into either the diseased or xerostomia group by abnormal oral cavity examination and symptoms, or the no xerostomia group, which was defined as dry mouth symptoms with no presence of abnormal physical findings. Results: Two hundred and two participants with a history of dry mouth were consecutively enrolled. There were 86 patients with physical findings compatible with xerostomia, and 116 symptomatic patients without xerostomia. Multivariate analysis revealed age over 50 years (adjusted odds ratio [aOR]: 3.1, 95% confidence interval [CI]: 1.3-7.9; p=0.012), analgesic and muscle relaxant intake (aOR: 3.6, 95% CI: 1.3-9.7; p=0.012), psychotherapeutic medication (aOR: 7.8, 95% CI: 2.6-23.7; p<0.001), and radioactive iodine therapy (aOR: 3.7, 95% CI: 1.2-11.8; p=0.015) to be independent predictors of xerostomia. Conclusion: Xerostomia is a condition that can adversely affect quality of life. The results of this study revealed older age (≥50 years), analgesics and muscle relaxants, psychotherapeutic medications, and radioactive iodine therapy to be significantly associated with xerostomia. A thorough understanding of the symptoms, diagnosis, relevant risk factors, and effective management is essential for improving outcomes among patients with xerostomia.

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“…In another study of young adults, researchers did indicate a difference between the sexes for xerostomia (19.6% in females and 14.6% in males) [21]. Researchers exploring xerostomia in different psychological disorders found more female patients than male patients had xerostomia [22]. They also found nearly half of patients with anxiety and depression, and over a third of patients with schizophrenia had xerostomia [22].…”

Section: Introductionmentioning

confidence: 92%

“…Researchers exploring xerostomia in different psychological disorders found more female patients than male patients had xerostomia [22]. They also found nearly half of patients with anxiety and depression, and over a third of patients with schizophrenia had xerostomia [22].…”

Section: Introductionmentioning

confidence: 99%

Stimulated Hyposalivary Flow Rates in Healthcare Students in an Interprofessional Awareness Educational Program Curriculum

Wiener

Morgan

Swager

et al. 2017

Journal of Biomedical Education

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properly cited.Purpose. Hyposalivation influences quality of life and medication compliance. However, oral health knowledge (in general) and knowledge about hyposalivation (in particular) are often lacking in nondental healthcare professional's curricula. Additionally, hyposalivation has not been adequately studied in young adults. The purpose for this study is twofold: to use an interprofessional educational curriculum to increase nondental healthcare students' knowledge about oral health and salivary testing and determine whether hyposalivation is different between sexes in young adults. Method. First-year medical and pharmacy students ( = 178) learned the process of saliva collection and provided samples in an interprofessional program. Results. There were 14.4% of participants with hyposalivation; 72.0% were female. Males had higher flow rates ( = 0.005). There failed to be a significant difference between the sexes with frank hyposalivation. There failed to be a significant difference in hyposalivation and medication use/nonuse. Conclusions. Hyposalivation is a biomedical, public health concern. However, in this young population, there was no significant difference between sexes or in medication use/nonuse. Through participation in the program, the students learned about salivary flow rates and the need for collaboration among professionals to prevent negative impacts of hyposalivation and oral health.

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Evaluation of Xerostomia in Different Psychological Disorders: An Observational Study

Cited by 16 publications

References 24 publications

Relationship among perceived stress, xerostomia, and salivary flow rate in patients visiting a saliva clinic

Relationship among perceived stress, xerostomia, and salivary flow rate in patients visiting a saliva clinic

Factors Associated with Xerostomia in Non-Radiated Patients

Stimulated Hyposalivary Flow Rates in Healthcare Students in an Interprofessional Awareness Educational Program Curriculum

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