Evaluation of wound healing potential of new composite liposomal films containing coenzyme Q10 and <scp>d</scp>-panthenyl triacetate as combinational treatment

Sagiroglu, Ali Asram; Çelik, Burak; Güler, Eray Metin; Koçyiğit, Abdürrahim; Özer, Özgen

doi:10.1080/10837450.2021.1887892

Cited by 4 publications

(6 citation statements)

References 43 publications

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“…In order to combat infections and promote skin regeneration in burn wounds, a variety of nanosized lipid-based delivery systems, including liposomes, transferosomes, ethosomes, and lipid nanoparticles, have been investigated. The results are encouraging [ 122 , 123 ].…”

Section: Localised Delivery Systems For Wound Healingmentioning

confidence: 99%

“…Due to their deformability and ability to resist dry environments, transferosomes can pass to deeper skin layers undamaged. Transferosomes are therefore typically used for transdermal medication delivery in addition to their potential for topical distribution due to their capacity to penetrate deeply through epidermal layers and reach systemic circulation without the risk of vesicle rupture [ 121 , 123 ].…”

Section: Localised Delivery Systems For Wound Healingmentioning

confidence: 99%

“…High entrapment efficiency is offered by phytosomes, which can be employed to distribute phytoconstituents topically for wound healing. The preparation was discovered to be risk-free and to have considerable antioxidant and wound-healing properties [ 123 , 124 , 125 ].…”

Section: Localised Delivery Systems For Wound Healingmentioning

confidence: 99%

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Local Drug Delivery Strategies towards Wound Healing

Tiwari

Pathak

2023

Pharmaceutics

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A particular biological process known as wound healing is connected to the overall phenomena of growth and tissue regeneration. Several cellular and matrix elements work together to restore the integrity of injured tissue. The goal of the present review paper focused on the physiology of wound healing, medications used to treat wound healing, and local drug delivery systems for possible skin wound therapy. The capacity of the skin to heal a wound is the result of a highly intricate process that involves several different processes, such as vascular response, blood coagulation, fibrin network creation, re-epithelialisation, collagen maturation, and connective tissue remodelling. Wound healing may be controlled with topical antiseptics, topical antibiotics, herbal remedies, and cellular initiators. In order to effectively eradicate infections and shorten the healing process, contemporary antimicrobial treatments that include antibiotics or antiseptics must be investigated. A variety of delivery systems were described, including innovative delivery systems, hydrogels, microspheres, gold and silver nanoparticles, vesicles, emulsifying systems, nanofibres, artificial dressings, three-dimensional printed skin replacements, dendrimers and carbon nanotubes. It may be inferred that enhanced local delivery methods might be used to provide wound healing agents for faster healing of skin wounds.

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Section: Localised Delivery Systems For Wound Healingmentioning

confidence: 99%

Section: Localised Delivery Systems For Wound Healingmentioning

confidence: 99%

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Local Drug Delivery Strategies towards Wound Healing

Tiwari

Pathak

2023

Pharmaceutics

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“…Besides intriguing advantages, liposomes might represent inappropriate wound dressing owing to low viscosity, which makes the healing process longer and causes complications such as infections. To overcome this, composites containing different scaffolds such as sodium alginate [ 76 ], chitosan [ 77 ], and three-dimensional supports would be provided to achieve sustained and controlled wound management [ 78 , 79 ]. Raj Kumar et al prepared collagen-based hydrogel as a scaffold to prolong the effect of liposomes loaded with vancomycin applied on MRSA-infected wounds [ 80 ].…”

Section: Mechanism Of Lipid-based Drug Delivery Systemsmentioning

confidence: 99%

Combinational System of Lipid-Based Nanocarriers and Biodegradable Polymers for Wound Healing: An Updated Review

Far

Naimi-Jamal

Sedaghat

et al. 2023

JFB

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Skin wounds have imposed serious socioeconomic burdens on healthcare providers and patients. There are just more than 25,000 burn injury-related deaths reported each year. Conventional treatments do not often allow the re-establishment of the function of affected regions and structures, resulting in dehydration and wound infections. Many nanocarriers, such as lipid-based systems or biobased and biodegradable polymers and their associated platforms, are favorable in wound healing due to their ability to promote cell adhesion and migration, thus improving wound healing and reducing scarring. Hence, many researchers have focused on developing new wound dressings based on such compounds with desirable effects. However, when applied in wound healing, some problems occur, such as the high cost of public health, novel treatments emphasizing reduced healthcare costs, and increasing quality of treatment outcomes. The integrated hybrid systems of lipid-based nanocarriers (LNCs) and polymer-based systems can be promising as the solution for the above problems in the wound healing process. Furthermore, novel drug delivery systems showed more effective release of therapeutic agents, suitable mimicking of the physiological environment, and improvement in the function of the single system. This review highlights recent advances in lipid-based systems and the role of lipid-based carriers and biodegradable polymers in wound healing.

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“…Recent studies highlighted that modern dressings with natural active compounds or HEs can be an ideal delivery system in wound healing [ 115 , 116 ]. In addition, other studies describing the incorporation of lipid vesicles in modern dressings for wound healing have shown promising results [ 117 , 118 , 119 , 120 ]. Although, a thorough search of the relevant literature yielded only a limited number of studies in which VNs with PCs were included in polymeric dressings for wound healing [ 31 , 94 ].…”

Section: Topical Delivery Systems Containing Herbal Extractsmentioning

confidence: 99%

Vesicular Nanocarriers for Phytocompounds in Wound Care: Preparation and Characterization

2022

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The need to develop wound healing preparations is a pressing challenge given the limitations of the current treatment and the rising prevalence of impaired healing wounds. Although herbal extracts have been used for many years to treat skin disorders, due to their wound healing, anti-inflammatory, antimicrobial, and antioxidant effects, their efficacy can be questionable because of their poor bioavailability and stability issues. Nanotechnology offers an opportunity to revolutionize wound healing therapies by including herbal compounds in nanosystems. Particularly, vesicular nanosystems exhibit beneficial properties, such as biocompatibility, targeted and sustained delivery capacity, and increased phytocompounds’ bioavailability and protection, conferring them a great potential for future applications in wound care. This review summarizes the beneficial effects of phytocompounds in wound healing and emphasizes the advantages of their entrapment in vesicular nanosystems. Different types of lipid nanocarriers are presented (liposomes, niosomes, transferosomes, ethosomes, cubosomes, and their derivates’ systems), highlighting their applications as carriers for phytocompounds in wound care, with the presentation of the state-of-art in this field. The methods of preparation, characterization, and evaluation are also described, underlining the properties that ensure good in vitro and in vivo performance. Finally, future directions of topical systems in which vesicle-bearing herbal extracts or phytocompounds can be incorporated are pointed out, as their development is emerging as a promising strategy.

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Evaluation of wound healing potential of new composite liposomal films containing coenzyme Q10 and d-panthenyl triacetate as combinational treatment

Cited by 4 publications

References 43 publications

Local Drug Delivery Strategies towards Wound Healing

Local Drug Delivery Strategies towards Wound Healing

Combinational System of Lipid-Based Nanocarriers and Biodegradable Polymers for Wound Healing: An Updated Review

Vesicular Nanocarriers for Phytocompounds in Wound Care: Preparation and Characterization

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