Evaluation of Wound Healing Effect of &lt;i&gt;Punica granatum&lt;/i&gt; L Peel Extract on Deep Second-Degree Burns in Rats

Ma, Keping; Du, Mindong; Liao, Mingde; Chen, Shihai; Yin, Guoqian; Li, Qingfeng; Wei, Qiang; Qin, G.

doi:10.4314/tjpr.v14i1.11

Cited by 23 publications

(14 citation statements)

References 13 publications

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“…Different extracts of P. granatum L. fruit peel such as aqueous extracts (10% and 20%) [240], 70% ethanol extract [234], a 5% (w/w) 75% methanol extract based-ointment [210] and a 10% and 15% (w/w) methanol extract based-ointment [241] were shown to enhance the healing of burn wounds and wounds by increasing wound contraction, reducing the period of epithelization and enhancing epithelialization. In addition, 70% ethanol extract was found to increase mean wound contraction (97 %) of deep second-degree skin burns in rats comparing to silver sulfadiazine (79 %) and its effect was comparable to the silver sulfadiazine in improving various phases of wound healing (reduction of inflammatory cells, increase in the formation of fibroblast, granulation tissues, collagen fibers, epithelialization and angiogenesis) [233]. Moreover, ethanol-water (3:1) extract showed wound healing percentage of 94.83% ± 0.44 comparing to the reference phenytoin with 96.00% ± 0.29 of rat's wounds after 14 days.…”

Section: •-mentioning

confidence: 87%

Evaluation of the wound healing activity of twelve herbal and non-herbal remedies used in Sana'a-Yemen for the treatment of wounds and burns

Alasbahi

Groot

2020

JMHE

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Wound healing is a complex process of integrated and overlapping phases resulting in the restoration of structural and functional integrity of injured tissues. Wounds and burn wounds represent a significant burden on the patients and health care professionals worldwide. There is still an obvious lack of suitable wound healing drugs since most of the available products can have some side effects and limitations. Traditional medicine has been practiced by the indigenous people of Yemen from antiquity until today. However, many of herbal and non-herbal products, used for wounds treatment, have not been the subject of any scientific investigation. Hence, the aim of this study was to document and scientifically evaluate the claimed wound healing efficiency of twelve herbal and non-herbal remedies (nine plants, one mineral (potassium alum), one marine product (cuttlefish bone) and one animal product (honey) used in Sana’a by indigenous people to treat wounds and burns. Searching electronic databases has indicated various experimental studies demonstrating four distinct pharmacological activities (anti-inflammatory, antioxidant, antimicrobial activities and promoting various phases of wound healing) displayed by the raw materials, extracts, chemical groups and some isolated compounds of the studied herbal and non-herbal remedies. Moreover, it has been found that the studied remedies do not produce serious side effects and can be considered generally safe upon appropriate topical usage. This study provides scientific data that support the wound healing efficiency of the studied remedies and thus lend some scientific justification for their traditional use in Sana’a for the treatment of wounds and burns. These herbal and non-herbal remedies can be considered as leads for future materials for wound healing and therefore further experimental and clinical studies are required to validate their effectiveness and safety.

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Section: •-mentioning

confidence: 87%

Evaluation of the wound healing activity of twelve herbal and non-herbal remedies used in Sana'a-Yemen for the treatment of wounds and burns

Alasbahi

Groot

2020

JMHE

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“…in traditional medicine agree with the uses that have been reported in P. granatum L., although P. granatum L. has more uses and has had more effects attributed to it. P. granatum L. is traditionally used for diarrhea, stomatitis, ulcers, bleeding, enemas, vaginal discharge, inflammation of the pancreas, gallbladder diseases, dysentery and stomach disorders, antiparasitic (taenicide and others), antibacterial, inflammatory diseases, astringent, abortion, burns, pain, snakebite, bronchitis, cough, and nausea [ 66 , 67 , 68 , 69 , 70 ]. Traditional and alternative medicine has many followers in the Republic of Yemen, because access to occidental medicine is still restricted, and Yemen is a country with difficult access [ 71 ].…”

Section: Discussionmentioning

confidence: 99%

Punica protopunica Balf., the Forgotten Sister of the Common Pomegranate (Punica granatum L.): Features and Medicinal Properties—A Review

Guerrero-Solano

Jaramillo-Morales

Cabrera

et al. 2020

Plants

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Punica protopunica Balf. is one of only two species housed by the Punica genera. Punica protopunica. Balf., known as Socotran pomegranate, is an endemic, isolated species found only in Socotra archipelago in the northwestern Indian Ocean, and is considered to be the ancestor of pomegranate. This review stems from the fact that in many Punica granatum L. articles, Punica protopunica Balf. is mentioned, but just in an informative way, without mentioning their taxonomic and genetic relationship and their medicinal properties. It is there where the need arises to know more about this forgotten species: “the other pomegranate tree.” A large part of the human population does not know of its existence, since only its “sister” has spread throughout the world. The present review deals with the taxonomy and origin of Punica protopunica Balf., the morphology of the tree, distribution, cultivation, vulnerability, and as well as its relationship with Punica granatum L. It also discusses its uses in traditional medicine, its antioxidant capacity, and the medicinal properties of this forgotten species.

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“…Aqueous extract of CLJE was obtained by steeping the dried Caulis lonicerae in water at 60 ℃ three times for 1 h each. The liquid extract was dried in an oven and freeze-dried to obtain CLJE [19]. The yield was 58.82 %.…”

Section: Experimental Preparation Of Caulis Lonicerae Extractmentioning

confidence: 99%

<i>Caulis Lonicerae</i> Japonicae extract shows protective effect on osteoporosis in rats

Li¹,

Mu²

2017

Trop. J. Pharm Res

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Evaluation of Wound Healing Effect of <i>Punica granatum</i> L Peel Extract on Deep Second-Degree Burns in Rats

Cited by 23 publications

References 13 publications

Evaluation of the wound healing activity of twelve herbal and non-herbal remedies used in Sana'a-Yemen for the treatment of wounds and burns

Evaluation of the wound healing activity of twelve herbal and non-herbal remedies used in Sana'a-Yemen for the treatment of wounds and burns

Punica protopunica Balf., the Forgotten Sister of the Common Pomegranate (Punica granatum L.): Features and Medicinal Properties—A Review

<i>Caulis Lonicerae</i> Japonicae extract shows protective effect on osteoporosis in rats

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