Evaluation of Wound Healing Activity of Ethanolic Extract of Pongamia pinnata Bark

Bhandirge, S. K.; Tripathi, Alok Shiomurti; Bhandirge, R. K.; Chinchmalatpure, T. P.; Desai, H G; Chandewar, A. V.

doi:10.1055/s-0034-1384537

Cited by 11 publications

(8 citation statements)

References 8 publications

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“…The stem bark extract has been shown to contain alkaloids, terpenoids (including triterpenes), steroids, flavonoids and volatile oils, with the isolated triterpenoid cycloart-23-ene-3β, 25-diol (B2) possessing antidiabetic activity and antioxidant activity in diabetic animals [63]. The bark has also been shown to have in vitro wound healing activity [64]. As M. pinnata has been noted to be a variable species and a number of varieties [65] it would of interest to further compare the medicinal activities and chemistry of M. pinnata native to northern Australia with that in other countries.…”

Section: Resultsmentioning

confidence: 99%

In vitro inhibitory activities of selected Australian medicinal plant extracts against protein glycation, angiotensin converting enzyme (ACE) and digestive enzymes linked to type II diabetes

Deo

Hewawasam

Karakoulakis

et al. 2016

BMC Complement Altern Med

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BackgroundThere is a need to develop potential new therapies for the management of diabetes and hypertension. Australian medicinal plants collected from the Kuuku I’yu (Northern Kaanju) homelands, Cape York Peninsula, Queensland, Australia were investigated to determine their therapeutic potential. Extracts were tested for inhibition of protein glycation and key enzymes relevant to the management of hyperglycaemia and hypertension. The inhibitory activities were further correlated with the antioxidant activities.MethodsExtracts of five selected plant species were investigated: Petalostigma pubescens, Petalostigma banksii, Memecylon pauciflorum, Millettia pinnata and Grewia mesomischa. Enzyme inhibitory activity of the plant extracts was assessed against α-amylase, α-glucosidase and angiotensin converting enzyme (ACE). Antiglycation activity was determined using glucose-induced protein glycation models and formation of protein-bound fluorescent advanced glycation endproducts (AGEs). Antioxidant activity was determined by measuring the scavenging effect of plant extracts against 1, 1-diphenyl-2-picryl hydrazyl (DPPH) and using the ferric reducing anti-oxidant potential assay (FRAP). Total phenolic and flavonoid contents were also determined.ResultsExtracts of the leaves of Petalostigma banksii and P. pubescens showed the strongest inhibition of α-amylase with IC50 values of 166.50 ± 5.50 μg/mL and 160.20 ± 27.92 μg/mL, respectively. The P. pubescens leaf extract was also the strongest inhibitor of α-glucosidase with an IC50 of 167.83 ± 23.82 μg/mL. Testing for the antiglycation potential of the extracts, measured as inhibition of formation of protein-bound fluorescent AGEs, showed that P. banksii root and fruit extracts had IC50 values of 34.49 ± 4.31 μg/mL and 47.72 ± 1.65 μg/mL, respectively, which were significantly lower (p < 0.05) than other extracts. The inhibitory effect on α-amylase, α-glucosidase and the antiglycation potential of the extracts did not correlate with the total phenolic, total flavonoid, FRAP or DPPH. For ACE inhibition, IC50 values ranged between 266.27 ± 6.91 to 695.17 ± 15.38 μg/mL.ConclusionsThe tested Australian medicinal plant extracts inhibit glucose-induced fluorescent AGEs, α-amylase, α-glucosidase and ACE with extracts of Petalostigma species showing the most promising activity. These medicinal plants could potentially be further developed as therapeutic agents in the treatment of hyperglycaemia and hypertension.Electronic supplementary materialThe online version of this article (doi:10.1186/s12906-016-1421-5) contains supplementary material, which is available to authorized users.

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Section: Resultsmentioning

confidence: 99%

In vitro inhibitory activities of selected Australian medicinal plant extracts against protein glycation, angiotensin converting enzyme (ACE) and digestive enzymes linked to type II diabetes

Deo

Hewawasam

Karakoulakis

et al. 2016

BMC Complement Altern Med

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“…Modern scientific literature also put forth evidences to support the ability of Pongamia pinnata to heal wounds . An experimental study has been conducted to evaluate the wound healing potential of Pongamia pinnata bark [ 16 ]. The rats have been treated with 10% and 5% ointment-based formulation topically.…”

Section: Discussionmentioning

confidence: 99%

Wound healing potential of bark paste of Pongamia pinnata along with hirudotherapy: A case report

Balasooriya

Karunarathna²,

Uluwaduge

2021

Journal of Ayurveda and Integrative Medicine

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Chronic wound is one of a leading cause of amputation worldwide. Successful management of chronic wound has become a challenge to all existing medical systems across the world. Sri Lankan Traditional and Ayurvedic medicine reveals many promising herbal and alternative remedies for chronic wounds. We hereby report a successfully managed case of an 80-year-old female patient suffering from a chronic wound for two years, when presenting has advised for amputation of the leg. The treatment protocol included the application of hirudotherapy along with the bark paste of Pongamia pinnata followed by Flueggea leucopyrus with recommended other external and internal remedies. At the end of the treatment protocol, pain, exudates, odor, burning sensation, and itching were reduced completely while swelling and wound size was reduced remarkably and showed a significant healing in the wounded area.

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“…[ 11 ] In general, plants which have antimicrobioal properties exhibit wound healing properties. Similarly, J. officinale ,[ 12 ] P. pinnata [ 13 ] and R. cordifolia [ 14 ] have shown wound healing properties in animal models.…”

Section: Discussionmentioning

confidence: 99%

Determination of antimicrobial potential of five herbs used in ayurveda practices against Candida albicans, Candida parapsilosis and methicillin resistant Staphylococcus aureus

et al. 2017

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Background:Medicinal plants are an important source of novel antimicrobial agents. Ayurvedic treatment involves the use of a variety of medicinal plants that merit investigation.Aims:To investigate the antimicrobial activity of bark of Pongamia pinnata (L.) Pierre, stem of Rubia cordifolia Linn, leaves of Jasminum officinale Linn, stem of Berberis ceylanica C.K. Schneid. and fruit of Garcina zeylanica Roxb.Subjects and Methods:Aqueous and ethanolic extracts of dried bark of Pongamia pinnata (Magul karanda), dried stem of Rubia cordifolia Linn (Welmadata), tender leaves of Jasminum officinale Linn (Jasmine) and dried stem of Berberis ceylanica (Dāruharidrā) were prepared according to standard protocols and tested for antimicrobial activity against five clinical isolates and one standard strain each of Candida albicans (ATCC 10231), Candida parapsilosis (ATCC 22019) and six Methicillin Resistant Staphylococcus aureus (MRSA) clinical isolates using the well diffusion method. Experiments were done in triplicates using well diffusion method. The plant extracts which gave a zone of inhibition in the well diffusion assay were further tested for Minimum Inhibitory Concentrations (MIC).Results:Aqueous and ethanolic extracts of Berberis ceylanica and ethanolic extract of Rubia cordifolia had antimicrobial activity against Candida albicans and Candida parapsilosis. Aqueous and ethanolic extracts of Garcinia zeylanica, and the ethanolic extracts of Jasminum officinale, Rubia cordifolia and Pongamia pinnata had antimicrobial activity against MRSA.Conclusions:Berberis ceylanica and Rubia crodifolia had antimicrobial activity against Candida species while Garcinia zeylanica, Jasminum officinale, Rubia crodifolia and Pongamia pinnata had antimicrobial activity against MRSA.

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Evaluation of Wound Healing Activity of Ethanolic Extract of Pongamia pinnata Bark

Cited by 11 publications

References 8 publications

In vitro inhibitory activities of selected Australian medicinal plant extracts against protein glycation, angiotensin converting enzyme (ACE) and digestive enzymes linked to type II diabetes

In vitro inhibitory activities of selected Australian medicinal plant extracts against protein glycation, angiotensin converting enzyme (ACE) and digestive enzymes linked to type II diabetes

Wound healing potential of bark paste of Pongamia pinnata along with hirudotherapy: A case report

Determination of antimicrobial potential of five herbs used in ayurveda practices against Candida albicans, Candida parapsilosis and methicillin resistant Staphylococcus aureus

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