Evaluation of whole left ventricular systolic performance and local myocardial systolic function in patients with prior myocardial infarction using global long-axis myocardial strain

Ohte, Nobuyuki; Narita, Hitomi; Miyabe, Hiromichi; Takada, Norio; Goto, Toshihiko; Mizuno, Hiroumi; Asada, Kaoru; Hayano, Junichiro; Kimura, Genjiro

doi:10.1016/j.amjcard.2004.06.031

Cited by 10 publications

(8 citation statements)

References 17 publications

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“…In a previous study, we reported an impairment of myocardial systolic function along the long-axis in the remote normal region of the left ventricle in patients with a prior MI [4,23]. In the present study, we demonstrated that early diastolic, but not systolic, myocardial function was impaired in the radial direction in the remote normal region in patients with a prior MI.…”

Section: Myocardial Function In the Remote Normal Regioncontrasting

confidence: 47%

Left ventricular remodeling after myocardial infarction impairs early diastolic, but not systolic, function in the radial direction in the remote normal region

et al. 2010

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Section: Myocardial Function In the Remote Normal Regioncontrasting

confidence: 47%

Left ventricular remodeling after myocardial infarction impairs early diastolic, but not systolic, function in the radial direction in the remote normal region

et al. 2010

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“…We have previously reported that, in the dilated LVof patients, the remote noninfarcted LV wall exhibited significantly reduced oxidative metabolism with moderate local myocardial systolic dysfunction [7]. In that study, the early stage of myocardial systolic dysfunction was recognized as a reduction in the peak systolic myocardial strain on the LV wall in the longitudinal direction [24][25][26][27][28].…”

Section: Discussionmentioning

confidence: 95%

Cardiac β-adrenergic receptor density and myocardial systolic function in the remote noninfarcted region after prior myocardial infarction with left ventricular remodelling

Ohte

Narita

Iida³

et al. 2012

Eur J Nucl Med Mol Imaging

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“…Recent advances in the ability to measure LV strain have afforded the opportunity to characterize myocardial contractility in a wide range of experimental and clinical settings (6,10,11,25,35,37,44). Normal values and measurement variability data for this imaging modality have recently been published (18,42).…”

Section: Discussionmentioning

confidence: 99%

The impact of endurance exercise training on left ventricular systolic mechanics

Baggish¹,

Yared²,

Wang³

et al. 2008

American Journal of Physiology-Heart and Circulatory Physiology

117

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Although exercise training-induced changes in left ventricular (LV) structure are well characterized, adaptive functional changes are incompletely understood. Detailed echocardiographic assessment of LV systolic function was performed on 20 competitive rowers (10 males and 10 females) before and after endurance exercise training (EET; 90 days, 10.7 Ϯ 1.1 h/wk). Structural changes included LV dilation (end-diastolic volume ϭ 128 Ϯ 25 vs. 144 Ϯ 28 ml, P Ͻ 0.001), right ventricular (RV) dilation (end-diastolic area ϭ 2,850 Ϯ 550 vs. 3,260 Ϯ 530 mm 2 , P Ͻ 0.001), and LV hypertrophy (mass ϭ 227 Ϯ 51 vs. 256 Ϯ 56 g, P Ͻ 0.001). Although LV ejection fraction was unchanged (62 Ϯ 3% vs. 60 Ϯ 3%, P ϭ not significant), all direct measures of LV systolic function were altered. Peak systolic tissue velocities increased significantly (basal lateral SЈ⌬ ϭ 0.9 Ϯ 0.6 cm/s, P ϭ 0.004; and basal septal SЈ⌬ ϭ 0.8 Ϯ 0.4 cm/s, P ϭ 0.008). Radial strain increased similarly in all segments, whereas longitudinal strain increased with a base-to-apex gradient. In contrast, circumferential strain (CS) increased in the LV free wall but decreased in regions adjacent to the RV. Reductions in septal CS correlated strongly with changes in RV structure (⌬RV end-diastolic area vs. ⌬LV septal CS; r 2 ϭ 0.898, P Ͻ 0.001) and function (⌬peak RV systolic velocity vs. ⌬LV septal CS, r 2 ϭ 0.697, P Ͻ 0.001). EET leads to significant changes in LV systolic function with regional heterogeneity that may be secondary to concomitant RV adaptation. These changes are not detected by conventional measurements such as ejection fraction.athlete's heart; left ventricle; strain; ventricular interdependence LEFT VENTRICULAR (LV) structural adaptation in response to aerobic endurance exercise training (EET) has been well characterized. Increases in LV chamber dimensions, wall thickness, and mass have been documented among individuals who participate in EET, and it is these structural attributes that underlie the concept of the "athlete's heart" (8,38,41). At the present time, the impact of EET on LV functional mechanics is less clear.Several reports demonstrate that EET results in enhanced LV diastolic function (3,23,31). In contrast, existing data suggest that LV systolic function is unchanged by EET (9,15,39). Previous studies examining the impact of EET on LV systolic function have relied on indexes such as ejection fraction or fractional area change that may lack the sensitivity to detect regional changes in myocardial function. Novel imaging techniques such as two-dimensional strain and tissueDoppler echocardiography are direct, more sensitive methods of assessing myocardial systolic function (13,14). To date, a prospective and longitudinal assessment of the impact of EET on LV systolic function using these techniques has not been conducted.We hypothesized that EET would result in enhanced resting LV contractility but that this adaptation would be underrepresented by conventional indexes of systolic function. To address this hypothesis, we performed a focused ...

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Evaluation of whole left ventricular systolic performance and local myocardial systolic function in patients with prior myocardial infarction using global long-axis myocardial strain

Cited by 10 publications

References 17 publications

Left ventricular remodeling after myocardial infarction impairs early diastolic, but not systolic, function in the radial direction in the remote normal region

Left ventricular remodeling after myocardial infarction impairs early diastolic, but not systolic, function in the radial direction in the remote normal region

Cardiac β-adrenergic receptor density and myocardial systolic function in the remote noninfarcted region after prior myocardial infarction with left ventricular remodelling

The impact of endurance exercise training on left ventricular systolic mechanics

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