Evaluation of Vulnerable Coronary Plaques and Non-Alcoholic Fatty Liver Disease (NAFLD) by 64-Detector Multislice Computed Tomography (MSCT)

Akabame, Satoshi; Hamaguchi, Masahide; Tomiyasu, Ki-ichiro; Tanaka, Muhei; Kobayashi-Takenaka, Yoshiko; Nakano, Koji; Oda, Y.; Yoshikawa, Toshikazu

doi:10.1253/circj.72.618

Cited by 108 publications

(78 citation statements)

References 35 publications

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“…24 Additionally, recently published studies underline the feasibility of coronary CTA to even detect coronary plaque and therefore clinically silent CAD. [25][26][27] A certain prognostic impact on the detection of coronary calcification and non-obstructive CAD is therefore assumed. [28][29][30] However, in clinical practice 2 major limitations are apparent: Firstly, coronary calcifications lead to overestimation of coronary stenoses because of blurring artefacts and total obstruction of the coronary lumen, and may significantly impair diagnostic accuracy 31,32 and thus lead to unnecessary invasive angiography.…”

Section: Discussionmentioning

confidence: 99%

Detection of Relevant Coronary Artery Disease Using Dual-Source Computed Tomography in a High Probability Patient Series Comparison With Invasive Angiography

Rixe

Rolf

Conradi

et al. 2009

Circ J

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Background Computed tomography (CT) enables detection of coronary artery stenoses, but its use is limited by deficient evaluation at elevated heart rates. The accuracy of dual-source CT (DSCT) for the detection of coronary artery disease (CAD) was assessed in 76 patients at high probability of CAD without heart rate control and compared with quantitative coronary angiography (QCA). Methods and ResultsThe 76 patients (47 males, mean age 65.5±10 years) underwent DSCT without preceding heart rate control. Data sets were evaluated by 2 observers in consensus with respect to stenoses >50% decreased diameter. QCA served as the standard of reference. Mean heart rate during scanning was 68±9 beats per min, and the average Agatston score was 337±560. Of 1,160 coronary artery segments, all but 3 were visualized artefactfree; 58 coronary stenoses were correctly detected by CT angiography. In the segment-based analysis, sensitivity was 98.3%, specificity 99.2% and accuracy 99%; patient based analysis revealed a sensitivity of 100%, specificity of 83.3% and overall accuracy of 92.1%. Conclusions Even at elevated heart rates, DSCT can reliably detect coronary artery stenoses and the results correlate well with those for invasive coronary angiography. (Circ J 2009; 73: 316 -322)

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Section: Discussionmentioning

confidence: 99%

Detection of Relevant Coronary Artery Disease Using Dual-Source Computed Tomography in a High Probability Patient Series Comparison With Invasive Angiography

Rixe

Rolf

Conradi

et al. 2009

Circ J

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“…16,17 Moreover, non-alcoholic fatty liver disease might be a stronger predictor than metabolic syndrome of cardiovascular disease. 18 In obese children, non-alcoholic fatty liver disease is associated with dyslipidemia, hypertension and glucose intolerance, and predicts development of these conditions.…”

Section: Introductionmentioning

confidence: 99%

Fatty liver incidence and predictive variables

et al. 2010

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Although fatty liver predicts ischemic heart disease, the incidence and predictors of fatty liver need examination. The objective of this study was to determine fatty liver incidence and predictive variables. Using abdominal ultrasonography, we followed biennially through 2007 (mean follow-up, 11.6±4.6 years) 1635 Nagasaki atomic bomb survivors (606 men) without fatty liver at baseline (November 1990 through October 1992. We examined potential predictive variables with the Cox proportional hazard model and longitudinal trends with the Wilcoxon rank-sum test. In all, 323 (124 men) new fatty liver cases were diagnosed. The incidence was 19.9/1000 person-years (22.3 for men, 18.6 for women) and peaked in the sixth decade of life. After controlling for age, sex, and smoking and drinking habits, obesity (relative risk (RR), 2.93; 95% confidence interval (CI), 2.33-3.69, Po0.001), low high-density lipoprotein-cholesterol (RR, 1.87; 95% CI, 1.42-2.47; Po0.001), hypertriglyceridemia (RR, 2.49; 95% CI, 1.96-3.15; Po0.001), glucose intolerance (RR, 1.51; 95% CI, 1.09-2.10; P¼0.013) and hypertension (RR, 1.63; 95% CI, 1.30-2.04; Po0.001) were predictive of fatty liver. In multivariate analysis including all variables, obesity (RR, 2.55; 95% CI, 1.93-3.38; Po0.001), hypertriglyceridemia (RR, 1.92; 95% CI, 1.41-2.62; Po0.001) and hypertension (RR, 1.31; 95% CI, 1.01-1.71; P¼0.046) remained predictive. In fatty liver cases, body mass index and serum triglycerides, but not systolic or diastolic blood pressure, increased significantly and steadily up to the time of the diagnosis. Obesity, hypertriglyceridemia and, to a lesser extent, hypertension might serve as predictive variables for fatty liver.

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“…The presence of ICAS remained a significant predictor of FLD after accounting for clinical variables in a logistic regression model. The presence of NAFLD has been reported to be associated with an increased coronary atherosclerotic burden (14,15) and is independent risk factor for diabetes mellitus (16). However, the effects of NAFLD on ischemic stroke, intracranial artery stenosis and carotid atherosclerosis remain unclear.…”

Section: Discussionmentioning

confidence: 99%

Relationship between Fatty Liver Disease and Intracranial Main Artery Stenosis

et al. 2014

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Objective The aim of this study was to evaluate the relationship between fatty liver disease (FLD) and cerebrovascular disease. Methods We conducted a cross-sectional study of 76 consecutive healthy subjects who participated in a two-day hospitalized health checkup program. The maximal intima-media thickness (IMT) of the common carotid artery and bifurcation of the carotid artery as well as the plaque score (PS) were evaluated on carotid artery ultrasonography. Fluid attenuated inversion recovery brain MRI was used to determine the presence of asymptomatic cerebral lesions and periventricular hyperintensity. Brain MR angiography was used to evaluate the degree of intracranial main artery stenosis (ICAS). FLD was diagnosed based on the ultrasonographic pattern.Results The PS and IMT did not differ between the FLD (n=24) and non-FLD (n=52) groups. There was a tendency toward a higher percentage of multiple lacunar lesions in the non-FLD group than in the FLD group. ICAS was significantly more frequent in subjects in the FLD group than those in the non-FLD group (25.0% vs. 5.8%). A logistic regression analysis revealed that age and FLD were significant determinants of ICAS. Conclusion Our study findings suggest a significant association between ICAS and FLD.

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Evaluation of Vulnerable Coronary Plaques and Non-Alcoholic Fatty Liver Disease (NAFLD) by 64-Detector Multislice Computed Tomography (MSCT)

Abstract: NAFLD is a novel risk factor for vulnerable plaques.

Cited by 108 publications

References 35 publications

Detection of Relevant Coronary Artery Disease Using Dual-Source Computed Tomography in a High Probability Patient Series Comparison With Invasive Angiography

Detection of Relevant Coronary Artery Disease Using Dual-Source Computed Tomography in a High Probability Patient Series Comparison With Invasive Angiography

Fatty liver incidence and predictive variables

Relationship between Fatty Liver Disease and Intracranial Main Artery Stenosis

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