Evaluation of Vitamin D Status in Rheumatoid Arthritis and Its Association with Disease Activity across 15 Countries: “The COMORA Study”

Hajjaj–Hassouni, N.; Mawani, N.; Allali, F.; Rkain, Hanan; Hassouni, K.; Hmamouchi, Ihsane; Dougados, Maxime

doi:10.1155/2017/5491676

Cited by 45 publications

(38 citation statements)

References 42 publications

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“…Also, a report including data of 15 different countries confirms variation of serum D vitamin levels [31]. This difference is explained due to the differences in people such as ethnic variation, climate, sun exposure, dressing style or latitude [7,31]. Since this study was performed in a rural area of Turkey, ethnic variations were not noted.…”

Section: Discussionmentioning

confidence: 67%

“…It was published that more vitamin D intake reduces the prevalence of RA in Northern Europe compared with Southern Europe [7]. Also, a report including data of 15 different countries confirms variation of serum D vitamin levels [31]. This difference is explained due to the differences in people such as ethnic variation, climate, sun exposure, dressing style or latitude [7,31].…”

Section: Discussionmentioning

confidence: 96%

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Vitamin D status and association with disease activity and quality of life in patients with rheumatoid arthritis

Şaş¹,

Koçak²,

Kurt³

et al. 2019

Ann Clin Anal Med

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Aim: The aim of this study is to determine the vitamin D level in patients with RA (Rheumatoid Arthritis) and association with clinic and laboratory parameters and quality of life. Material and Method: Out of 111 patients with RA and 107 healthy controls who were admitted to Ahi Evran University Training and Research Hospital were included in this study. Patients underwent clinical, laboratory, functional, and quality of life examination. Laboratory tests used for patient evaluations included complete blood count, erythrocyte sedimentation rate (ESR), C-reactive protein level (CRP). Disease activity was calculated by DAS28 (Disease Activity Score) and functional and quality of life was examined by RAQoL (Rheumatoid Arthritis Quality of Life), HAQ (Health Assessment Questionnaire). Larsen score was calculated to assess the radiographic damage. Results: There was no significant difference between the patient and control groups regarding age, sex and vitamin D level (p > 0.05). There were no correlation between vitamin D and Larsen score, RAQoL, HAQ, ESR, and CRP (p > 0,05). We found negative correlation between DAS28 (Disease Activity Score) and vitamin D (r = -0,416, p = 0,014). We found negative correlation between morning stiffness and vitamin D (r = -0,454, p = 0,007). Patients with RA were divided into two groups with D vitamin deficiency (0-19 ng / mL) and vitamin D ( > 20 ng / mL). There was a negative correlation with morning stiffness in the group with vitamin D deficiency (r = -0,454, p = 0,007). There was a negative correlation between DAS28 score and vitamin D deficiency (r = -0.416, p = 0.014). Discussion: This study presents a negative correlation between serum vitamin D level and DAS28. Since vitamin D has autoimmune roles, deficiency or inadequacy can cause flaring in patients with RA. In the light of these findings, we recommend vitamin D supplementation.

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Section: Discussionmentioning

confidence: 67%

Section: Discussionmentioning

confidence: 96%

Vitamin D status and association with disease activity and quality of life in patients with rheumatoid arthritis

Şaş¹,

Koçak²,

Kurt³

et al. 2019

Ann Clin Anal Med

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“…Many literature sources have reported a negative association between vitamin D level and age (Mithal et al, 2009;Anonymous, 2014;Hajjaj-Hassouni et al, 2017). This trend might be explained by vitamin D replacement therapy given often to infants and toddlers, which is discontinued as the child grows.…”

Section: Discussionmentioning

confidence: 99%

Level of 25-Hydroxyvitamin D in Pediatric Arthritis Patients

Laizāne

Saulīte

Feierābende

et al. 2019

Proceedings of the Latvian Academy of Sciences. Section B. Natural, Exact, and Applied Sciences.

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Vitamin D deficiency is common and widespread globally. Vitamin D has an immunomodulatory effect, but it is still unclear whether its deficiency is associated with higher disease activity. The aim of this retrospective study was to determine the serum concentration of vitamin D in children with paediatric arthritis (juvenile idiopathic arthritis and reactive arthritis). Prevalence of hypo-vitaminosis D among 98 children with juvenile idiopathic arthritis and reactive arthritis was determined and association between serum concentration of vitamin D and disease activity markers was found. Prevalence of vitamin D deficiency among children included in this study was 69.07%. Children with juvenile idiopathic arthritis had a significantly lower vitamin D level than children with reactive arthritis. There was a statistically significant moderate negative correlation between serum concentration of vitamin D and patient age, as well as a weak negative correlation between vitamin D level and patient body mass index. The significant correlations found between vitamin D level and inflammatory markers indicate that further research on the role of vitamin D in disease activity is needed.

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“…In RA patients, the efficacy of vitamin D intervention is controversial. Indeed, a large number of studies have confirmed that vitamin D deficiency exists in RA patients in different countries and low levels of vitamin D are associated with increased disease activity, glucocorticoid dosage and RA complications [16]. Another study documented an inverse correlation between the severity of depression and anxiety in RA patients and the level of serum vitamin D3 [17].…”

Section: Sift Deskmentioning

confidence: 99%

Can dietary intervention be an auxiliary therapy for Rheumatoid Arthritis?

Luo¹,

Bai²,

Zhang³

et al. 2018

SDRP-JFST

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Diet is an important environmental factor in the process of rheumatoid arthritis (RA) development. In the clinic, patients with RA often inquire about dietary advice. Dietary intervention has become an attractive alternative option for rheumatism because of dissatisfaction with pharmacological treatments and the increasing demands for therapeutic efficacy. Different nutrients in the diet and different dietary patterns affect RA in various ways. Some nutritional ingredients and dietary choices such as omega-3 polyunsaturated fatty acid, cheese lactobacillus, Mediterranean diet and vegetarian diet are beneficial for the control and mitigation of RA. Inappropriate iron supplement, high sugar and high fat diet have adverse effect on RA in patients. Though several recommendations on dietary intervention could be given based on existing research, more accurate and definitive studies are still needed to explore the auxiliary therapeutic effect of dietary intervention on RA.

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Evaluation of Vitamin D Status in Rheumatoid Arthritis and Its Association with Disease Activity across 15 Countries: “The COMORA Study”

Cited by 45 publications

References 42 publications

Vitamin D status and association with disease activity and quality of life in patients with rheumatoid arthritis

Vitamin D status and association with disease activity and quality of life in patients with rheumatoid arthritis

Level of 25-Hydroxyvitamin D in Pediatric Arthritis Patients

Can dietary intervention be an auxiliary therapy for Rheumatoid Arthritis?

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