Evaluation of visual recognition memory for the early diagnosis of Alzheimer's disease in patients over 75 years

Poissonnet, Aurore; Henry–Feugeas, Marie-Cécile; Drunat, O.; Wolmark, Y.; Delpierre, S.; Koskas, P.

doi:10.1016/j.neurol.2011.11.004

Cited by 6 publications

(3 citation statements)

References 27 publications

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“…Although the experimental visual recognition task did not clearly perform beyond neuropsychological tasks that have previously been shown to be useful in predicting AD (like logical memory) and performed only slightly beyond the FCSR, it is complimentary to standard measures as it improves their diagnostic accuracy. It is significant that one study reported discordances in older aMCI patients with some patients failing on the DMS48 while succeeding on the FCSRT and vice versa, which confirms that the tasks are complimentary in that they assess memory based on different sensory modalities and, possibly, distinct aspects of declarative memory [33]. This joins previous proposals that combining tasks that assess different types of memory increases the diagnostic accuracy of AD in aMCI patients [34,35.…”

Section: Discussionsupporting

confidence: 71%

Impaired Visual Recognition Memory Predicts Alzheimer's Disease in Amnestic Mild Cognitive Impairment

Didic¹,

Félician²,

Barbeau

et al. 2013

Dement Geriatr Cogn Disord

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Background: In the common form of Alzheimer's disease (AD), neurofibrillary tangles, which are associated with cognitive dysfunction, initially develop in the anterior subhippocampal (perirhinal/entorhinal) cortex before reaching the hippocampus. This area plays a key role in visual recognition memory (VRM). Impaired VRM could therefore be an early marker of AD. Methods: An extensive neuropsychological assessment including VRM tasks was performed in 26 patients with single-domain amnestic mild cognitive impairment at baseline. We evaluated the diagnostic accuracy of neuropsychological tests using ROC curve analyses in a prospective longitudinal study until conversion to probable AD or with a follow-up of at least 6 years. Results: VRM performance predicted conversion to AD with a sensitivity of 80% and a specificity of 90.9%. Combining the assessment of VRM with a verbal memory task increased diagnostic accuracy. Conclusions: Cognitive ‘biomarkers' evaluating the function of brain areas that are the target of degenerative change should be considered for the early diagnosis of AD.

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Section: Discussionsupporting

confidence: 71%

Impaired Visual Recognition Memory Predicts Alzheimer's Disease in Amnestic Mild Cognitive Impairment

Didic¹,

Félician²,

Barbeau

et al. 2013

Dement Geriatr Cogn Disord

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“…Memory impairment in old age is a hallmark of the initial stage of Alzheimer’s disease (AD), with dementia developing in the final stages ( Poissonnet et al, 2012 ). AD is characterized by the extensive deposition of amyloid β (Aβ), outside of neurons, and the formation of neurofibrillary tangles (NFTs) consisting of hyperphosphorylated tau, as intraneuronal inclusions ( Selkoe, 1986 ).…”

Section: Alzheimer’s Disease and Memorymentioning

confidence: 99%

GSK-3β and memory formation

Takashima¹

2012

Front. Mol. Neurosci.

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In Alzheimer’s disease (AD), tau hyperphosphorylation and neurofibrillary tangle (NFT) formation are strongly associated with dementia, a characteristic and early feature of this disease. Glycogen synthase kinase 3β (GSK-3β) is a pivotal kinase in both the normal and pathological phosphorylation of tau. In the diseased state, hyperphosphorylated tau is deposited in NFTs, the formation of which, drive the disease process. GSK-3β which is also involved in long-term depression induction, interacts with tau to inhibit synaptic long-term potentiation. Strong lines of evidence suggest that the activation of GSK-3β is responsible for the memory deficits seen in both advanced age and AD. In this review, we will focus on the role of GSK-3β in brain function, particularly in memory maintenance. We will examine human and mouse studies which suggest a role for GSK-3β in memory maintenance and the eventual development of memory deficits.

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“…Dans cette étude prospective, les auteurs ont montré que les performances au DMS 48 prédisaient une démence de type Alzheimer probable chez des patients présentant un MCI de type « amnésique » avec une sensibilité de 80 % et une spécificité de 91 %. Toutefois, ces valeurs sont améliorées lorsque l'épreuve du DMS 48 est combinée à une tâche de mémoire verbale montrant ainsi la complémentarité de ces épreuves permettant d'évaluer la mémoire déclarative à partir de différentes modalités sensorielles [32].…”

Section: Discussionunclassified

The DMS 48: norms and diagnostic proprieties for Alzheimer's disease in elderly population from the AMI cohort study

Rullier¹,

Matharan²,

Barbeau³

et al. 2014

Gériatrie Et Psychologie Neuropsychiatrie Du Viellissement

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Le DMS 48 est une épreuve de mémoire de reconnaissance visuelle à choix forcé, développée pour le diagnostic précoce de la maladie d'Alzheimer (MA). L'objectif de cette étude est d'établir des scores normatifs pour ce test et d'étudier sa validité dans la détection de la MA en comparaison avec l'épreuve de mémoire de récit de Wechsler. Méthodes. Cette étude a été réalisée à partir des données de la cohorte AMI (Approche multidisciplinaire intégrée). Le sous-échantillon pour les normes comprend 750 sujets âgés non déments ; celui de l'étude de validité comprend 751 sujets dont 34 MA. Résultats. Les normes ont été établies en fonction de l'âge, du sexe et du niveau d'études. Concernant la validité, le DMS 48 présente un bon équilibre entre sa sensibilité (Se) et sa spécificité (Sp) à la fois pour le rappel immédiat (Se = 70,6 % ; Sp = 79,6 %) et le rappel différé (Se = 79,4 % ; Sp = 72,9 %). Il présente des valeurs prédictives négatives élevées, autour de 98,5 % pour les deux rappels. Conclusion. Le DMS 48 présente des capacités de détection équivalentes à l'épreuve de mémoire épisodique. Le DMS 48 est un outil simple à utiliser en pratique clinique pouvant s'avérer utile dans une démarche diagnostique de MA.Mots clés : mémoire de reconnaissance visuelle, DMS 48, normes, propriétés de détection, maladie d'Alzheimer, sujet âgé Abstract. The DMS 48 is a visual recognition memory test designed to detect memory changes in early Alzheimer's disease (AD). The aim of this study was to produce normative scores for this test and to assess its psychometric properties in the detection of AD by comparison with a widely used test of verbal episodic memory: the story recall task of the Wechsler memory scale. Methods. Data were collected in a sample of 1002 agricultural retirees, aged 65 years and over, included in the AMI study, a population-based cohort conducted in Southwestern France. The sample used to establish normative data included 750 non-demented elderly while the sample used to study the properties of the test to detect AD included 751 participants whose 34 with AD. To assess AD detection accuracy, DMS 48 was compared to the Wechsler story recall task. Results. Age, sex, and education were significantly associated with DMS 48 performances. Therefore, normative scores were calculated according to sex, age, and educational level, and described by percentiles. Regarding the test properties for AD detection, DMS 48 presented a good balance between sensitivity (Se) and specificity (Sp) both for immediate (Se = 70.6%; Sp = 79.6%) and delayed recall (Se = 79.4%; Sp = 72.9%). It also showed high negative predictive values, around 98.5% for both recalls. Detection values were roughly similar to that of Wechsler story recall task. Conclusion: The DMS 48 seems to be as reliable as the Wechsler story recall task with similar detection properties. The DMS 48 is a test easy to administer in clinical situations and could be a helpful tool for AD screening.

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Evaluation of visual recognition memory for the early diagnosis of Alzheimer's disease in patients over 75 years

Cited by 6 publications

References 27 publications

Impaired Visual Recognition Memory Predicts Alzheimer's Disease in Amnestic Mild Cognitive Impairment

Impaired Visual Recognition Memory Predicts Alzheimer's Disease in Amnestic Mild Cognitive Impairment

GSK-3β and memory formation

The DMS 48: norms and diagnostic proprieties for Alzheimer's disease in elderly population from the AMI cohort study

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