Evaluation of visceral adiposity index with cardiovascular risk factors, biomarkers in postmenopausal women to predict cardiovascular disease: A 10 year study

Gulbahar, Aysegul; Caglar, Gamze Sınem; Arslanca, Tufan

doi:10.1016/j.exger.2022.111986

Cited by 4 publications

(6 citation statements)

References 29 publications

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“…In a prospective cohort study conducted in Europe, Koulii et al found that VAI was independently associated with a 10-year risk of CVD, especially in males, and its relevance was not affected by potential confounding factors such as lifestyle factors ( 39 ). On the contrary, Aysegul et al conducted a prospective cohort study on 55 postmenopausal women and found that there was no significant association between VAI and 10-year CVD risk ( 40 ). Our research on American adults aged 40–79 shows that there is a significant correlation between AVI and the 10-year ASCVD risk, and this relationship is more pronounced in males, which is similar to the findings of Koulii et al This gender difference may be due to the fact that men and women differ greatly in body fat distribution, with men being more prone to visceral fat accumulation than women ( 41 , 42 ).…”

Section: Discussionmentioning

confidence: 99%

Association between visceral obesity and 10-year risk of first atherosclerotic cardiovascular diseases events among American adults: National Health and Nutrition Examination Survey

Zheng,

Sun,

Han

et al. 2023

Front. Cardiovasc. Med.

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BackgroundIn the United States, the relationship between visceral obesity and the risk of developing atherosclerosis cardiovascular disease (ASCVD) for the first time in 10 years is unclear.MethodsData for this cross-sectional study came from the National Health and Nutrition Examination Survey (NHANES) from 2011 to 2020. We collected variable information related to 10-year ASCVD risk and visceral obesity reliable indicators [Visceral obesity index (VAI) and Lipid accumulation product (LAP)]. And we used multiple logistic regression to analyze the correlation of visceral obesity indicators (VAI and LAP) with 10-year ASCVD risk. In addition, we assessed the linear relationship between VAI or LAP and 10-year ASCVD risk by smoothing curve fitting. Finally, we conducted subgroup analysis and sensitivity analysis after excluding participants with extreme VAI and LAP values to ensure that we obtained accurate and reliable results.ResultsOur study included a total of 1,547 participants (mean age: 56.5 ± 10.1, 60% of males). The results of the multiple logistic regression showed that compared with participants with the lowest VAI in the 1st Quartile (≤0.79), the adjusted OR values for VAI and elevated 10-year ASCVD risk in Q3 (1.30–2.14), and Q4 (≥2.15) were 2.58 (95% CI: 1.24–5.36, P = 0.011), 15.14 (95% CI: 6.93–33.05, P < 0.001), respectively. Compared with participants with the lowest LAP in the 1st Quartile (≤28.29), the adjusted OR values for VAI and elevated 10-year ASCVD risk in Q3 (46.52–77.00), and Q4 (≥77.01) were 4.63 (95% CI: 2.18–9.82, P < 0.001), 16.94 (95% CI: 6.74–42.57, P < 0.001), respectively. Stratified analysis showed that the association between VAI or LAP and the first ASCVD event was more pronounced in males.ConclusionHigher VAI or LAP scores are significantly associated with elevated 10-year ASCVD risk in adults aged 40 to 79 in the USA, which suggested that monitoring visceral obesity is crucial to reduce the risk of a first ASCVD event.

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Section: Discussionmentioning

confidence: 99%

Association between visceral obesity and 10-year risk of first atherosclerotic cardiovascular diseases events among American adults: National Health and Nutrition Examination Survey

Zheng,

Sun,

Han

et al. 2023

Front. Cardiovasc. Med.

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“…WHR is a marker of central obesity and its effect was independent from BMI in linear regression models, which suggest that this association between VFS 20th percentile and WHR could be related mainly to body fat redistribution effect, rather than a global body mass increase. Abdominal fat is a recognized factor for metabolic syndrome ( 21 ). Menopause is linked to estrogens decrease and testosterone increase and this hormonal change is accompanied by a redistribution of body fat from a female to a male type with an accumulation in the abdominal compartment ( 22 ).…”

Section: Discussionmentioning

confidence: 99%

“…This suggests that body fat redistribution, associated to menopause transition, precedes the shift from a protective to a risky vascular profile and the onset of other systemic factors such hypertension. In fact has been reported that cardiovascular disease affects women up to 10 years later than men, although later on, the prognosis is worse and the mortality rate is higher in women ( 21 ). Regarding association between PA and VFS 20th percentile in men, light PA in leisure time was inversely associated while recommended moderate to vigorous PA showed a positive association.…”

Section: Discussionmentioning

confidence: 99%

Adherence to the Mediterranean diet and waist-to-hip ratio in middle-aged postmenopausal women are the main factors associated with semantic verbal fluency 12 years later

et al. 2023

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Few studies have analized the effect of vascular risk factors and lifestyle habits affecting the middle age of postmenopausal women on later cognitive performance in old age. We have carried out an observational study to identify those factors and whether they differ from those acting in men. Postmenopausal women and males, both aged 40–60 years old at recruitment, from a community dwelling cohort were included. Data for this study were collected from the first visit at recruitment (2001 to 2005). Participants were interviewed with a questionnaire on their health-related antecedents and underwent a physical exam. The cohort was contacted again for a new presential visit between 2014 and 2015. A semantic verbal fluency test was included in this new visit protocol as a brief measure of cognition. Besides educational attainment, Mediterranean diet adherence 20th percentile (OR = 1.93; 95%CI = 1.07–3.47) and waist to hip ratio 80th percentile (OR = 1.81; 95%CI = 1.10–2,98) were the main factors associated to low semantic fluency performance in postmenopausal women, while declared diabetes mellitus (OR = 2.24; 95%CI = 1.16–4,33), HOMA 2 insulin resistance index (OR = 1.77; 95%CI =1.04–3,02), light physical activity in leisure time (OR = 0.41; 95%CI = 0.19–0,93) and recommended moderate to vigorous physical activity (OR = 2.09; 95%CI = 1.23–3.56) did in men. Factors in middle age that explain semantic verbal fluency in old age are different between postmenopausal women and men. Menopause related fat redistribution may be a precondition for other vascular risk factors. The effect of Mediterranean diet on cognition deserves new specific studies centered on postmenopausal women as group.

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“…Sin embargo, no ha mostrado eficacia predictiva en grupos de riesgo como las mujeres posmenopáusicas 25 .…”

Section: Discussionunclassified

Relación predictiva de los índices de adiposidad visceral y adiposidad disfuncional con el riesgo cardiovascular en población laboral

Vicente-Herrero,

Egea Sancho,

Ramírez Iñiguez de la Torre

et al. 2023

Rev Clín Med Fam

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Objetivo: estimar la capacidad predictiva de los índices de adiposidad visceral (VAI) y disfuncional (DAI) en riesgo cardiovascular (RCV) de población laboral española. Métodos: análisis descriptivo en 418.343 trabajadores españoles de diferentes sectores durante la vigilancia de la salud en sus empresas. Se calculó el VAI y el DAI ajustándose a sus ecuaciones y el RCV mediante Registre Gironí del Cor (REGICOR), Systematic Coronary Risk Evaluation (SCORE) y estudio DORICA. Se estimó fortaleza asociativa mediante curvas de características operativas del receptor (ROC). El programa estadístico fue SPSS 27.0, considerando significación estadística p < 0,05. Resultados: los valores de RCV con los tres métodos son más elevados en hombres (p < 0,0001). El RCV más alto en mujeres se obtiene con REGICOR (1,58%) y en hombres con Score (11,28%). Con los métodos de valoración de RCV utilizados en ambos sexos, los valores medios de VAI y DAI van aumentando según lo hace el RCV. VAI y DAI son estimadores útiles de RCV en mujeres con DORICA AUC (área bajo la curva)-VAI 0,865 (intervalo de confianza [IC] 95%: 0,836-0,894) y AUC-DAI 0,859 (IC 95%: 0,829-0,888). En hombres, solo muestran moderada capacidad predictiva (valores AUC-VAI 0,774 (IC 95%: 0,768-0,780), AUC-DAI 0,762 (IC 95%: 0,756-0,768). La fortaleza asociativa es baja en ambos sexos con Score y REGICOR (AUC < 0,7). Conclusión: VAI y DAI aumentan sus valores medios según aumenta el RCV estimado con REGICOR, SCORE y DORICA. VAI y DAI tienen elevada capacidad predictiva con el RCV estimado con DORICA en mujeres y moderada fortaleza en hombres. Palabras clave: riesgo cardiovascular, índice de adiposidad visceral, índice de adiposidad disfuncional, salud laboral.

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Evaluation of visceral adiposity index with cardiovascular risk factors, biomarkers in postmenopausal women to predict cardiovascular disease: A 10 year study

Cited by 4 publications

References 29 publications

Association between visceral obesity and 10-year risk of first atherosclerotic cardiovascular diseases events among American adults: National Health and Nutrition Examination Survey

Association between visceral obesity and 10-year risk of first atherosclerotic cardiovascular diseases events among American adults: National Health and Nutrition Examination Survey

Adherence to the Mediterranean diet and waist-to-hip ratio in middle-aged postmenopausal women are the main factors associated with semantic verbal fluency 12 years later

Relación predictiva de los índices de adiposidad visceral y adiposidad disfuncional con el riesgo cardiovascular en población laboral

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