Evaluation of Villus Synovium From Unaffected Metacarpophalangeal Joints of Adult and Juvenile Horses

Tommasa, Simone Della; Winter, Karsten; Seeger, Johannes; Spitzbarth, Ingo; Brehm, Walter; Troillet, Antonia

doi:10.1016/j.jevs.2021.103637

Cited by 5 publications

(10 citation statements)

References 25 publications

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“…The significance of the synovial membrane in the pathogenesis of OA has been highlighted in the literature. It is posited that the synovial membrane serves as the primary target of ACS products [ 22 ]. While ACS appears effective in reducing synovitis and inflammatory cytokine production, its direct impact on cartilage regeneration remains uncertain.…”

Section: Discussionmentioning

confidence: 99%

“…In fact, according to previous studies, other tissues might be the main target for ACS actions in articular injuries because, for example, ACS had no impact on cartilage metabolism [ 17 , 19 , 20 , 21 ]. For instance, it has been established that the synovial membrane is a rich source of the inflammatory mediators and proteolytic enzymes that feed the chain of harmful intra-articular events that result in cartilage destruction [ 22 ]. As synovitis has been implicated in playing a significant role in OA, synovial tissues could be significant targets for the treatment of this condition [ 2 , 23 , 24 , 25 , 26 ].…”

Section: Discussionmentioning

confidence: 99%

“…The effects of the ACS products on the in vitro study also showed an improvement in cartilage regeneration [ 19 ]. Because the improvement in the cartilaginous surface could be directly correlated to the reduction in the inflammatory cytokines into the synovial fluid, the main target of the ACS products could be the synovial membrane [ 21 , 22 , 23 , 27 , 28 ].…”

Section: Discussionmentioning

confidence: 99%

“…The synovial membrane plays a crucial role in OA pathogenesis and is likely a key target for ACS products. This assumption suggests that ACS products may primarily alleviate synovitis and reduce inflammatory cytokine production, rather than directly promoting cartilage regeneration in joints with extensive cartilage damage [ 2 , 21 , 22 ]. In addition, the effects on articular cartilage are unlikely sufficient to support disease-modifying osteoarthritic drugs’ effects at this time [ 6 , 7 ].…”

Section: Discussionmentioning

confidence: 99%

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Use of Autologous Conditioned Serum (ACS) for Osteoarthritis Treatment in Horses: A Systematic Review of Clinical Data

Della Tommasa,

Brehm,

Farì

et al. 2023

Veterinary Sciences

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The utilization of Autologous Conditioned Serum (ACS) for treating osteoarthritis (OA) in horses has seen a notable increase in recent years. In vitro studies have consistently identified ACS as a promising therapy for OA joints, contributing to its growing popularity in OA treatment. Despite this, there is a noticeable absence of systematic reviews focused solely on the clinical data of OA patients treated with ACS, excluding the in vitro perspective. This study aims to address this gap by systematically reviewing the latest literature, concentrating solely on clinical data in in vivo studies to evaluate the efficacy of ACS in OA lesions. All clinical studies involving ACS treatments for horses with OA were included in the assessment. Surprisingly, only six trials met the inclusion criteria for this systematic review. The results indicate that the majority of the considered articles support the use of ACS as a treatment for horses, albeit with a control group provided in only one study. However, the absence of a control group and the exclusion of histological evaluation diminish the validity of the majority of clinical research. While several studies suggest a beneficial effect of ACS on OA horses without significant adverse effects, this systematic review affirms that there is no definitive evidence for its effectiveness. Therefore, further investigation of the efficacy of ACS products as a treatment for OA is warranted, emphasizing the need for more controlled trials. Poorly designed and biased studies, lacking blinding or control and adopting inadequate outcome measures, may favor positive results and, thus, necessitate a more rigorous approach to validate the efficacy of ACS in OA treatment.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Use of Autologous Conditioned Serum (ACS) for Osteoarthritis Treatment in Horses: A Systematic Review of Clinical Data

Della Tommasa,

Brehm,

Farì

et al. 2023

Veterinary Sciences

Self Cite

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“…Knee osteoarthritis (KOA) is the most common form of limb osteoarthritis [ 1 ]. It is a chronic joint disease which is characterized by degenerative lesions of the articular cartilage that progressively cause pain, motor impairment and, in the most severe cases, deformation of the joint itself [ 2 , 3 ]. Although one of the main risk factors is old age, as KOA predominantly affects people in their 70s [ 4 ], KOA is also increasing in patients aged between 45 and 70 [ 5 ], emerging recently as a very relevant problem for society and placing it among the most common causes of disability [ 6 ].…”

Section: Introductionmentioning

confidence: 99%

Hemp Seed Oil in Association with β-Caryophyllene, Myrcene and Ginger Extract as a Nutraceutical Integration in Knee Osteoarthritis: A Double-Blind Prospective Case-Control Study

et al. 2023

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Background and Objectives: Nutraceuticals are gaining more and more importance as a knee osteoarthritis (KOA) complementary treatment. Among nutraceuticals, hemp seed oil and terpenes are proving to be very useful as therapeutic support for many chronic diseases, but there are still few studies regarding their effectiveness for treating KOA, both in combination and separately. The aim of this study is thus to compare the effect of two dietary supplements, both containing hemp seed oil, but of which only one also contains terpenes, in relieving pain and improving joint function in patients suffering from KOA. Materials and Methods: Thirty-eight patients were recruited and divided into two groups. The control group underwent a 45 day treatment with a hemp seed oil-based dietary supplement, while the treatment group assumed a hemp seed oil and terpenes dietary supplement for the same period. Patients were evaluated at the enrollment (T0) and at the end of treatment (T1). Outcome measures were: Numeric Rating Scale (NRS), Oswestry Disability Index (ODI), Short-Form-12 (SF-12), Knee Injury Osteoarthritis Outcome Score (KOOS), and Oxford Knee Score (OKS). Results: All outcome measures improved at T1 in both groups, but NRS, KOOS and OKS had a greater significant improvement in the treatment group only. Conclusions: Hemp seed oil and terpenes resulted a more effective integrative treatment option in KOA, improving joint pain and function and representing a good complementary option for patients suffering from osteoarthritis.

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Cartilage damage: clinical approach

Farì¹,

Pignatelli²,

Macchiarola³

et al. 2022

Minerva Orthop

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Evaluation of Villus Synovium From Unaffected Metacarpophalangeal Joints of Adult and Juvenile Horses

Cited by 5 publications

References 25 publications

Use of Autologous Conditioned Serum (ACS) for Osteoarthritis Treatment in Horses: A Systematic Review of Clinical Data

Use of Autologous Conditioned Serum (ACS) for Osteoarthritis Treatment in Horses: A Systematic Review of Clinical Data

Hemp Seed Oil in Association with β-Caryophyllene, Myrcene and Ginger Extract as a Nutraceutical Integration in Knee Osteoarthritis: A Double-Blind Prospective Case-Control Study

Cartilage damage: clinical approach

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