Accidental poisonings are one of the leading safety threats for young children, so it is important to teach children to avoid ingesting poisonous substances. The purpose of this study was to evaluate the effectiveness of video modeling to teach three children diagnosed with autism spectrum disorder to avoid poison hazards. Results showed that video modeling was not effective for any of the participants, but that in situ training was effective for two participants, while the third participant required an additional incentive. Two out of three of the participants maintained the safety skills for 1, 3, and 5-week follow-up assessments.