Evaluation of ventricular repolarization variables in pediatric COVID-19

Abstract

Introduction Although the childhood clinic of COVID-19 is more innocent than adults, its unknown aspects continue to cause concern among pediatricians. One of these unsettling aspects is the cardiovascular system effects. We investigate the role of ventricular repolarization parameters in predicting arrhythmia risk in pediatric COVID-19. Materials and MethodsTwelve-channel surface electrocardiograms of a total of 166 participants, including children diagnosed with COVID-19 and healthy controls, were analyzed. The QT interval, corrected QT interval, QTc dispersion, Tpeak-Tend, Tp-e dispersion, Tp-e / QT and Tp-e / QTc ratio were calculated. The correlations between ventricular repolarization parameters and laboratory values were examined.Results In our study, the COVID-19 patients had a significantly longer Tpeak-Tend (64.51 ± 8.64 and 57.62 ± 7.96; p < 0.001), Tp-e dispersion (21.77 ± 6.4 and 18.01 ± 6.78; p < 0.001), and corrected QT interval (393.18 ± 20.06 and 380 ± 22.3; p < 0.001) duration than the control group. There was a significantly higher Tp-e / QT ratio (0.17 ± 0.02 and 0.15 ± 0.02; p < 0.001), Tp-e / QTc ratio (0.16 ± 0.02 and 0.15 ± 0.02; p < 0.001) in group with COVID-19 than the controls. In addition a positive correlation was found between Tpeak-Tend interval, Tp-e dispersion and white blood cells in the group with SARS CoV2 infection.Conclusion Evaluating these ventricular repolarization parameters in pediatric SARS CoV2 infection may be useful in predicting the risk of ventricular arrhythmia. Keywords COVID-19; child; ventricular repolarization abnormality ÖzAmaç COVID-19'un çocukluklardaki kliniği, yetişkinlere kıyasla daha masum seyretse de bilinmeyen yönleri pediatristler arasında endişe yaratmaya devam ediyor. Bu tedirgin edici yönlerinden biri de kardiyovasküler sistem etkileridir. Biz de bu çalışmada pediyatrik COVID-19'da aritmi riskini tahmin etmede ventriküler repolarizasyon parametrelerinin rolünü araştırmayı amaçladık. Yöntem ve GereçlerCOVID-19 teşhisi konan çocuklar ve sağlıklı kontroller dahil olmak üzere toplam 166 katılımcının on iki kanallı yüzey elektrokardiyogramı analiz edildi. Tp-e intervali, Tp-e dispersiyonu, Tp-e / QT oranı, Tp-e / QTc oranı, QT intervali, QTc intervali ve QTc dispersiyonu değerleri hesaplandı. Ventriküler repolarizasyon parametreleri ile laboratuvar değerleri arasındaki korelasyonlar incelendi.

Relation of High Sensitive Troponin-I and C-reactive Protein to Mortality in Patients with COVID-19

“…Th e number of new cases continues to increase and more than two million people died due to COVID 19 pandemic to date. [1][2][3] Data from studies and clinical experiences around the world have focused on eff orts to determine the better treatment protocol and reduce the mortality due to COVID-19. Several studies showed that numareous biomarkers, such as C-reactive protein, D-dimer, leukocyte, procalcitonin, interleukin 10 and interleukin 6 increase with the initiation and the progression of the COVID-19.…”