Evaluation of Venezuelan Medicinal Plant Extracts for Antitumor and Antiprotease Activities

Taylor, Peter; Cesari, Italo M.; Arsenak, Miriam; Ballén, Diana; Abad, María Jesús; Fernández, Agustina Fernández; Milano, Balentina; Ruiz, Marie Christine; Williams, Beatriz; Michelangeli, Fabián A.

doi:10.1080/13880200600748119

Cited by 22 publications

(14 citation statements)

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“…Of the 20,000 plant species described in Venezuela, 1,500 of them are used for medicinal purposes (Taylor et al, 2006). ent-Kaurenic acid and many natural derivatives of this diterpene are known to have interesting biological properties (Ghisalberti, 1997).…”

Section: Introductionmentioning

confidence: 99%

Cytotoxic and apoptosis-inducing effect of ent-15-oxo-kaur-16-en-19-oic acid, a derivative of grandiflorolic acid from Espeletia schultzii

Ruiz¹,

Rodrígues

Arvelo³

et al. 2008

Phytochemistry

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Section: Introductionmentioning

confidence: 99%

Cytotoxic and apoptosis-inducing effect of ent-15-oxo-kaur-16-en-19-oic acid, a derivative of grandiflorolic acid from Espeletia schultzii

Ruiz¹,

Rodrígues

Arvelo³

et al. 2008

Phytochemistry

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“…Extratos de folhas, sementes e cascas de T. guianensis apresentaram atividade citotóxica, sendo promissor o uso contra diversas linhagens de células tumorais (David et al, 1998;Taylor et al, 2006;Mahmoud et al, 2011). Além dessa, a atividade in vitro antileishmaniose, antimalárica, antibacteriana e antifúngica foram detectadas, para substâncias isoladas do extrato clorofórmico das suas cascas (Roumy et al, 2009).…”

Section: Introductionunclassified

Multiplicação in vitro de Tapirira guianensis Aubl. (Anacardiaceae)

et al. 2013

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In vitro multiplication of Tapirira guianensis Aubl. (Anacardiaceae)Tapirira guianensis is of great medicinal, ecological and socio-economical importance occurring throughout the Brazilian territory. The objective of this study was to establish and determine the best conditions for the in vitro multiplication of T. guianensis. The explants nodal, cotyledonary and epicotyl segments from seedlings germinated in vitro were tested in diverse concentrations of 6-benzilaminopurine (BAP) and/or napthaleneacetic acid (NAA) in medium WPM. The following parameters were evaluated: the percentage of responsive explants, the number of shoots and buds, and the length of shoots and shoot dry mass at 30 and 60 days after inoculation. The cotyledonary segment, under these conditions, is the most suitable explant for the multiplication, with no induction of adventitious buds in epicotyl. The treatment with 1.0 mg L -1 BAP in the absence of NAA is the most responsive to the T. guianensis regeneration.Key words: medicinal woody, in vitro propagation, regeneration, direct organogenesis. Tapirira guianensis possui grande relevância medicinal, ecológica e socioeconômica, ocorrendo em todo o territó-rio brasileiro. O objetivo deste estudo foi estabelecer e determinar as melhores condições para a sua multiplicação in vitro. Os explantes, segmentos nodais, cotiledonares e epicótilos, oriundos de plântulas germinadas in vitro, foram testados em concentrações de 6-benzilaminopurina (BAP) e, ou, ácido naftalenoacético (ANA), em meio de cultura WPM. As características avaliadas foram a percentagem de explantes responsivos, o número de brotos e de gemas, o comprimento dos brotos e a matéria seca da parte aérea, aos 30 e 60 dias após inoculação. Foi observado que o segmento cotiledonar, nas condições deste estudo, foi o explante mais indicado para a multiplicação, não havendo indução de brotos adventícios nos epicótilos. O tratamento com 1,0 mg L -1 de BAP na ausência de ANA é o mais responsivo para a regeneração de T. guianensis.Palavras-chave: lenhosa medicinal, propagação in vitro, regeneração, organogênese direta.

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“…The NCI screening programme counts among its successes, the identification of paclitaxel from taxus brevifolia, which was originally included in a blind mass screening of plant extracts without recourse to the then available ethnobotanical information on its traditional use (Heinrich and Bremner, 2006). In our studies on Venezuelan plants, we initially began by selecting plants from databases of botanical collections and ethnobiological usage, testing 17 plants for antitumour activity (Taylor et al, 2006), but then adopted a more shotgun approach to a study of cytostatic and cytotoxic activity against tumour cell lines in 308 extracts. There were two reasons for this, the first, simply, that we had the capacity to do it, that is, test all the extracts then available to us.…”

Section: Mass Screening Vs Selection According To Traditional Usementioning

confidence: 99%