Evaluation of Uv-Radiation Induced Singlet Oxygen Generation Potential of Selected Drugs

Pandey, R. K.; Mehrotra, Santosh; Ray, Ratan Singh; Joshi, P. C.; Hans, R.K.

doi:10.1081/dct-120003261

Cited by 12 publications

(7 citation statements)

References 37 publications

(34 reference statements)

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“…This reaction can be seen with initial exposure to a drug and is perhaps dose-related [75,76]. Photosensitization reactions of drugs lead to the formation of ROS and cause indirect DNA damage [77-80]. It may occur due to topical or systemic drugs (Table 2) [81].…”

Section: Results – Melanoma Risk Factorsmentioning

confidence: 99%

Associations between environmental factors and incidence of cutaneous melanoma. Review

et al. 2012

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BackgroundCutaneous melanoma is one of the most serious skin cancers. It is caused by neural crest-derived melanocytes - pigmented cells normally present in the epidermis and, sometimes, in the dermis.MethodsWe performed a review of current knowledge on the risk factors of cutaneous melanoma. Relevant studies were identified using the PubMed, Science Direct, Medline, Scopus, Scholar Google and ISI Web of Knowledge databases.ResultsMelanoma incurs a considerable public health burden owing to the worldwide dramatic rise in incidence since the mid-1960s. Ultraviolet radiation exposure is the predominant environmental risk factor. The role of geographical (latitude) and individual factors such as skin type, life style, vitamin D levels and antioxidant protection, sunburn, and exposure to other environmental factors possibly contributing to melanoma risk (such as cosmetics including sunscreen, photosensitising drugs, and exogenous hormones) are reviewed in this article. Recently, both rare high risk susceptibility genes and common polymorphic genes contributing to melanoma risk have been identified.ConclusionsCutaneous melanoma is a complex cancer with heterogeneous aetiology that continues to increase in incidence. Introduction of new biomarkers may help to elucidate the mechanism of pathogenesis and individual susceptibility to the disease, and make both prevention and treatment more effective.

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Section: Results – Melanoma Risk Factorsmentioning

confidence: 99%

Associations between environmental factors and incidence of cutaneous melanoma. Review

et al. 2012

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“…Phototoxicity can occur through photosensitization, the generation of biologically damaging reactive oxygen species and free radicals, or through photomodification, wherein UV degraded products are substantially more toxic than their parent compounds (ARFSTEN et al, 1996). Phototoxic compounds include natural plant compounds (LARSON and BERENBAUM, 1988), pharmaceuticals (PANDEY et al, 2002), pesticides (HASSPIELER et al, 1990;ZAGA et al, 1998), explosives (DAVE et al, 2000), metals (HANSEN et al, 2002;BAUD and BECK, 2005), and PAHs (KAGAN et al, 1987;ARFSTEN et al, 1996). Phototoxic compounds may reduce the ability to evade predators (DUESTERLOH et al, 2002), and depress reproduction (HOLST and GIESY, 1989).…”

Section: Uv Contaminant Toxicity and Nutrient Cyclingmentioning

confidence: 98%

Ultraviolet Insights: Attempting to Resolve Enigmatic Patterns in Pelagic Freshwaters – The Historical Context and a View to the Future

Williamson

Rose

2009

International Review of Hydrobiology

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While great advances have been made in our understanding of pelagic freshwater communities and ecosystems in recent years, several unexplained patterns continue to evade our understanding. While no single factor can explain these enigmatic patterns, recent increases in our understanding of the ecology of ultraviolet radiation (UV) are consistent with UV playing an important role. Here we present a brief overview of why UV has historically received so little attention in pelagic freshwater ecosystems, review some of the important aspects of the ecology of UV that are important to these enigmatic patterns, and discuss how this new understanding of the ecology of UV may provide some insights into these previously unexplained patterns. IntroductionGreat advances have been made in our understanding of the structure and function of pelagic freshwater communities and ecosystems in recent years. Yet there are several compelling patterns in these systems that remain enigmatic. For example, Why are laboratory experiments that manipulate pH not adequate to explain the response • of many aquatic organisms to anthropogenic acidification of inland waters? Why is it that zooplankton continue to exhibit vertical migration in lakes where there are • no visual predators to induce their migration? Why are some contaminants so much more toxic when exposure occurs in the sunlight? • Why do decreases in water transparency lead to decreases in species diversity in African • cichlids? Recent advances in our understanding of the ecology of ultraviolet radiation (UV) in freshwaters suggest that UV plays a key role in explaining some portion of these enigmatic observations. UV may also play an important role in understanding the causes and consequences of some more recently observed patterns and trends in freshwaters. For example, Freshwater lakes undergo seasonal increases in transparency to visible light known as a • clear-water phase. Recent studies indicate that these clear-water phases are also observed in the UV wavelengths, but are they driven by the same ecological forces? What are the implications of these DOC trends for the role of UV in freshwaters, and can these changes in UV be used as a metric of environmental change at local and global scales? Here we briefly explore the historical development of the study of the ecology of UV in pelagic freshwaters and examine the potential importance of UV in explaining both these past enigmatic patterns as well as recent trends of environmental change. While no single factor is likely to explain these enigmatic patterns and trends, we argue that UV is a much more potent force in pelagic ecosystems than is currently recognized. We begin here by discussing the variability in UV transparency among and within lakes and outline the historical context of the study of UV in freshwaters. We then briefly discuss some of the important aspects of the ecology of UV before addressing how UV can help us to understand the questions outlined above. We conclude with some brief thoughts on how stud...

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“…However, the full spectrum of solar radiation has wavelengths with considerable damaging potential. Photooxidative stress is primarily caused by the absorption of light by the organic molecules [1,2]. The absorption of electromagnetic radiation of a tissue depends on the excitability of its molecules.…”

Section: Pterygium; Uveal Melanomamentioning

confidence: 99%

The Influence of Ultraviolet Radiation on Eye

Stojičić¹

2013

Primary Health Care

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Evaluation of Uv-Radiation Induced Singlet Oxygen Generation Potential of Selected Drugs

Cited by 12 publications

References 37 publications

Associations between environmental factors and incidence of cutaneous melanoma. Review

Associations between environmental factors and incidence of cutaneous melanoma. Review

Ultraviolet Insights: Attempting to Resolve Enigmatic Patterns in Pelagic Freshwaters – The Historical Context and a View to the Future

The Influence of Ultraviolet Radiation on Eye

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